PUBLICATION

The phylogenetic relationship of the glutamate and pheromone g-protein-coupled receptors in different vertebrate species

Authors
Bjarnadóttir, T.K., Schiöth, H.B., and Fredriksson, R.
ID
ZDB-PUB-050518-5
Date
2005
Source
Annals of the New York Academy of Sciences   1040: 230-233 (Journal)
Registered Authors
Fredriksson, Robert
Keywords
evolution; GPCRs; metabotropic glutamate receptors; pheromone receptors
MeSH Terms
  • Animals
  • Humans
  • Phylogeny*
  • Receptors, G-Protein-Coupled/genetics
  • Receptors, Glutamate/genetics*
  • Receptors, Pheromone/genetics*
  • Species Specificity
  • Vertebrates
PubMed
15891031 Full text @ Ann N Y Acad Sci
Abstract
Searches in genomic databases for human, mouse, zebrafish, and pufferfish genes resulted in the identification of more than 180 protein predictions belonging to the glutamate family of G-protein-coupled receptors (GPCRs). Comparison of data sets from the different species showed that most of the receptor subgroups that form the glutamate family are present in both mammalian and bony fish lineage. This finding indicates that these groups share a phylogenetically ancient origin. The present study also shows that the pheromone-receptor subgroup has undergone independent expansions in three of the four species, leaving the human genome completely deprived of all pheromone receptors.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping