PUBLICATION
The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells
- Authors
- Bierie, B., Edwin, M., Joseph Melenhorst, J., and Hennighausen, L.
- ID
- ZDB-PUB-040609-7
- Date
- 2004
- Source
- Gene expression patterns : GEP 4(4): 389-395 (Journal)
- Registered Authors
- Hennighausen, Lothar
- Keywords
- Proliferation associated nuclear element, Zebrafish, beta-Catenin, Leukemia, Lymphoma, PANE1
- MeSH Terms
-
- Animals
- B-Lymphocytes/metabolism*
- Cell Line, Tumor
- Humans
- Lymphocyte Activation/genetics
- Lymphocyte Activation/physiology*
- Mice
- Neoplasms/genetics
- Neoplasms/metabolism*
- Nuclear Proteins/biosynthesis
- Nuclear Proteins/genetics*
- Sequence Homology, Amino Acid
- T-Lymphocytes/metabolism*
- Zebrafish/genetics
- Zebrafish Proteins/genetics*
- PubMed
- 15183305 Full text @ Gene Expr. Patterns
Citation
Bierie, B., Edwin, M., Joseph Melenhorst, J., and Hennighausen, L. (2004) The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. Gene expression patterns : GEP. 4(4):389-395.
Abstract
The proliferation associated nuclear element (PANE1) had been identified in a screen for genes activated in mouse mammary epithelium transformed by stabilized beta-catenin. We have now cloned the human and zebrafish orthologs, analyzed their expression and expressed them ectopically in tissue culture cell lines. PANE1 consists of 180 amino acids and displays 38% conservation between man and zebrafish. Expression of the human PANE1 gene was detected preferentially in immune cells including leukemias and lymphomas, tumor tissues and tumor derived cell lines. In B- and T-cells PANE1 RNA was only detected after the respective cell types were activated either in vivo or in vitro.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping