ZFIN ID: ZDB-PUB-040421-3
Towing of sensory axons by their migrating target cells in vivo
Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C.
Date: 2004
Source: Nature Neuroscience 7(5): 491-492 (Journal)
Registered Authors: Gilmour, Darren, Knaut, Holger, Maischein, Hans-Martin, Nüsslein-Volhard, Christiane
Keywords: none
MeSH Terms: Animals; Animals, Genetically Modified; Axons/physiology*; Cell Communication/genetics*; Cell Movement/physiology* (all 22) expand
PubMed: 15097993 Full text @ Nat. Neurosci.
ABSTRACT
Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.
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