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ZFIN ID: ZDB-PUB-030910-5
Chemical genetics: adding to the developmental biology toolbox
Yeh, J.-R. and Crews, C.M.
Date: 2003
Source: Developmental Cell   5(1): 11-19 (Review)
Registered Authors: Yeh, Jing-Ruey (Joanna)
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation
  • Developmental Biology*
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental/drug effects*
  • Humans
  • Models, Biological
  • Molecular Biology*
  • Mutation
  • Signal Transduction
  • Teratogens/toxicity
  • Vertebrates/embryology
  • Vertebrates/genetics
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed: 12852848 Full text @ Dev. Cell
Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.