PUBLICATION
Development of the zebrafish inner ear
- Authors
- Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B.
- ID
- ZDB-PUB-020403-2
- Date
- 2002
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 223(4): 427-458 (Journal)
- Registered Authors
- Riley, Bruce, Whitfield, Tanya T.
- Keywords
- zebrafish; otic placode; otic vesicle; statoacoustic ganglion; lateral line; hair cell; supporting cell; hearing; balance; auditory; vestibular; cell death; retinoic acid; BMP; Claudins; Dach; Delta-Notch; Eya1; FGF; Krml1
- MeSH Terms
-
- Animals
- Body Patterning
- Ear, Inner/anatomy & histology
- Ear, Inner/embryology
- Ear, Inner/growth & development*
- Epithelium
- Humans
- Morphogenesis
- Zebrafish/anatomy & histology
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/growth & development*
- PubMed
- 11921334 Full text @ Dev. Dyn.
Citation
Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B. (2002) Development of the zebrafish inner ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(4):427-458.
Abstract
Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping