PUBLICATION
Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos
- Authors
- Ohtoshi, A., Nishijima, I., Justice, M.J., and Behringer, R.R.
- ID
- ZDB-PUB-011220-3
- Date
- 2002
- Source
- Mechanisms of Development 110(1-2): 241-244 (Journal)
- Registered Authors
- Behringer, Richard
- Keywords
- Paired-like class homeodomain; Diencephalon; Mesencephalon; Neural patterning
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Body Patterning/genetics
- Brain/embryology*
- Chromosome Mapping
- Conserved Sequence
- Evolution, Molecular
- Gene Expression Regulation, Developmental
- Genes, Homeobox*
- Genetic Linkage
- Humans
- In Situ Hybridization
- Male
- Mice
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Zebrafish
- PubMed
- 11744391 Full text @ Mech. Dev.
Citation
Ohtoshi, A., Nishijima, I., Justice, M.J., and Behringer, R.R. (2002) Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos. Mechanisms of Development. 110(1-2):241-244.
Abstract
To identify novel homeobox genes expressed during mouse embryogenesis, we searched the databases and found a novel mouse paired-like homeobox gene, Dmbx1(diencephalon/mesencephalon-expressed brain homeobox gene 1), that is also conserved in zebrafish and human. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4 that is the homologous gene cluster region of human chromosome 1, where human DMBX1 is located. Both mouse and human Dmbx1/DMBX1 have four coding exons and their gene structures are conserved. Whole-mount in situ hybridization revealed that Dmbx1 expression is detected in 7.5-9.5 dpc mouse embryos. At 7.5 and 8.5 dpc, Dmbx1 is expressed in a sub-region of the anterior head folds. At 9.5 dpc, expression is observed in the caudal diencephalon as well as in the mesencephalon and is restricted to the neuroepithelium. Expression in adult tissues was detected in brain, stomach, and testis. Dmbx1 provides a unique marker of the developing anterior ! nervous system and should provide a useful molecular resource to elucidate the mechanisms that pattern the vertebrate brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping