PUBLICATION
Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution
- Authors
- Hahn, Y., Lee, Y.J., Yun, J.H., Yang, S.K., Park, C.W., Mita, K., Huh, T., Rhee, M., and Chung, J.H.
- ID
- ZDB-PUB-001101-5
- Date
- 2000
- Source
- FEBS letters 482(1-2): 31-36 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Bombyx/genetics
- Carrier Proteins/chemistry
- Carrier Proteins/genetics*
- Coatomer Protein*
- Drosophila melanogaster/genetics
- Evolution, Molecular*
- Gene Duplication*
- Humans
- Insecta
- Male
- Mice
- Molecular Sequence Data
- Phylogeny*
- Plants
- Sequence Alignment
- Sequence Homology, Amino Acid
- Testis/metabolism
- Vertebrates
- Zebrafish/genetics
- PubMed
- 11018518 Full text @ FEBS Lett.
Citation
Hahn, Y., Lee, Y.J., Yun, J.H., Yang, S.K., Park, C.W., Mita, K., Huh, T., Rhee, M., and Chung, J.H. (2000) Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. FEBS letters. 482(1-2):31-36.
Abstract
Coatomer is a major component of COPI vesicles and consists of seven subunits. The gamma-COP subunit of the coatomer is believed to mediate the binding to the cytoplasmic dilysine motifs of membrane proteins. We characterized cDNAs for Copg genes encoding gamma-COP from mouse, zebrafish, Drosophila melanogaster and Bombyx mori. Two copies of Copg genes are present in vertebrates and in B. mori. Phylogenetic analysis revealed that two paralogous genes had been derived from a single ancestral gene by duplication independently in vertebrates and in B. mori. Mouse Copg1 showed ubiquitous expression with the highest level in testis. Zebrafish copg2 was biallelically expressed in hybrid larvae in contrast to its mammalian ortholog expressed in a parent-of-origin-specific manner. A phylogenetic analysis with partial plant cDNA sequences suggested that copg gene was also duplicated in the grass family (Poaceae).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping