PUBLICATION
Sensory deafferentation and olfactory bulb morphology in the zebrafish and related species
- Authors
- Poling, K.R. and Brunjes, P.C.
- ID
- ZDB-PUB-000309-39
- Date
- 2000
- Source
- Brain research 856(1-2): 135-141 (Journal)
- Registered Authors
- Brunjes, Peter C.
- Keywords
- development; cyprinidae; olfactory deprivation; Danio rerio; Danio aequipinnatus; Rasbora trilineata; Barbus titteya
- MeSH Terms
-
- Animals
- Cyprinidae/anatomy & histology
- Cyprinidae/physiology*
- Olfactory Bulb/anatomy & histology
- Olfactory Bulb/growth & development
- Olfactory Bulb/physiology*
- Olfactory Pathways/anatomy & histology
- Olfactory Pathways/physiology*
- Species Specificity
- Zebrafish/anatomy & histology
- Zebrafish/physiology*
- PubMed
- 10677620 Full text @ Brain Res.
Citation
Poling, K.R. and Brunjes, P.C. (2000) Sensory deafferentation and olfactory bulb morphology in the zebrafish and related species. Brain research. 856(1-2):135-141.
Abstract
The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from hatching to adulthood. In young animals, the bulb is small relative to body size and has a higher percentage of its volume occupied by incoming olfactory nerve fibers. Young animals are also more affected by sensory deafferentation. Olfactory rosette removal resulted in more than 50% reductions in laminar volumes, indicating that sensory input is important during periods of rapid development. In addition, three closely related species were examined to compare how differing bulb morphology might influence the effects of bulb manipulation. The cherry barb, Barbus (=Puntius) titteya, and giant danio, Danio aequipinnatus, have larger bulbs and laminar volumes relative to body size than the zebrafish or scissortail rasbora, Rasbora trilineata. Both are also more affected by deafferentation, with at least a 35% reduction in laminar sizes in many of the bulb layers. The studies are discussed in terms of the importance of the olfactory system to each species and are also compared to the effects of sensory manipulations in other animals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping