PUBLICATION

Developmental expression of a novel Ftz-F1 homologue, ff1b (NR5A4), in the zebrafish Danio rerio

Authors
Chai, C. and Chan, W.
ID
ZDB-PUB-000309-22
Date
2000
Source
Mechanisms of Development   91(1-2): 421-426 (Journal)
Registered Authors
Chan, Woon-Khiong
Keywords
zebrafish; Ftz-F1; embryogenesis; pancreas; rostral diencephalon; hypothalamus; one-eyed pinhead; Danio rerio
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins/genetics*
  • Transcription Factors/genetics*
  • Zebrafish/embryology*
  • Zebrafish Proteins
PubMed
10704877 Full text @ Mech. Dev.
Abstract
The Ftz-F1 genes encode orphan receptors of the nuclear receptor superfamily. The mammalian Ftz-F1 homologue, SF-1, has been found to be essential for the proper development of the adrenal-gonadal axis and it also plays a critical role in mammalian sex-determination. We report here the isolation and characterisation of a novel zebrafish Ftz-F1 gene, ff1b. Whole-mount in situ hybridization revealed onset of expression in the developing rostral diencephalon at 22 h post-fertilization (h.p.f.). Later, at 30 h.p.f., transcripts could be detected in the anterior regions of the pancreatic anlagen. Expression in both locations peaks at 36 h.p.f. and disappears at around 48 h.p.f.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes