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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-990225-9
Waskiewicz, Andrew
Email: aw@ualberta.ca
URL: http://www.biology.ualberta.ca/faculty/andrew_waskiewicz/index.php?Page=2376
Affiliation: Waskiewicz Lab
Address: Department of Biological Sciences Faculty of Science University of Alberta CW-405 Biological Sciences Building Edmonton, Alberta, T6G 2E9 Canada
Country: Canada
Phone: (780) 492-4403
Fax: (780) 492-9234
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Hocking, J.C., Famulski, J.K., Yoon, K.H., Widen, S.A., Bernstein, C.S., Koch, S., Weiss, O., FORGE Canada Consortium, Agarwala, S., Inbal, A., Lehmann, O.J., Waskiewicz, A.J. (2018) Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye. PLoS Genetics. 14:e1007246
Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
Pillay, L.M., Mackowetzky, K.J., Widen, S.A., Waskiewicz, A.J. (2017) Correction: Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS One. 12:e0171058
Pillay, L.M., Mackowetzky, K.J., Widen, S.A., Waskiewicz, A.J. (2016) Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS One. 11:e0166040
Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63
Liu, C., Widen, S.A., Williamson, K.A., Ratnapriya, R., Gerth-Kahlert, C., Rainger, J., Alur, R.P., Strachan, E., Manjunath, S.H., Balakrishnan, A., Floyd, J.A., Li, T., Waskiewicz, A., Brooks, B.P., Lehmann, O.J., FitzPatrick, D.R., Swaroop, A. (2016) A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Human molecular genetics. 25(7):1382-91
French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81
Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J. (2014) Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development. Developmental Biology. 388(2):192-204
Pillay, L.M., Selland, L.G., Fleisch, V.C., Leighton, P.L., Cheng, C.S., Famulski, J.K., Ritzel, R.G., March, L.D., Wang, H., Allison, W.T., and Waskiewicz, A.J. (2013) Evaluating the Mutagenic Activity of Targeted Endonucleases Containing a Sharkey FokI Cleavage Domain Variant in Zebrafish. Zebrafish. 10(3):353-64
Pant, S.D., March, L.D., Famulski, J.K., French, C.R., Lehmann, O.J., and Waskiewicz, A.J. (2013) Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. Investigative ophthalmology & visual science. 54(8):5871-5879
Drummond, D.L., Cheng, C.S., Selland, L.G., Hocking, J.C., Prichard, L.B., and Waskiewicz, A.J. (2013) The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Developmental Biology. 13:31
French, C.R., Stach, T.R., March, L.D., Lehmann, O.J., and Waskiewicz, A.J. (2013) Apoptotic and proliferative defects characterize ocular development in a microphthalmic BMP model. Investigative ophthalmology & visual science. 54(7):4636-4647
Fleisch, V.C., Leighton, P.L., Wang, H., Pillay, L.M., Ritzel, R.G., Bhinder, G., Roy, B., Tierney, K.B., Ali, D.W., Waskiewicz, A.J., and Allison, W.T. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of disease. 55:11-25
Asai-Coakwell, M., March, L., Dai, X.H., Duval, M., Lopez, I., French, C.R., Famulski, J., De Baere, E., Francis, P.J., Sundaresan, P., Sauvé, Y., Koenekoop, R.K., Berry, F.B., Allison, W.T., Waskiewicz, A.J., and Lehmann, O.J. (2013) Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Human molecular genetics. 22(7):1432-1442
Lukowski, C.M., Drummond, D.L., and Waskiewicz, A.J. (2011) Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos. Genome. 54(12):973-85
Erickson, T., Pillay, L.M., and Waskiewicz, A.J. (2011) Zebrafish Tshz3b negatively regulates Hox function in the developing hindbrain. Genesis (New York, N.Y. : 2000). 49(9):725-42
Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J. (2011) Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning. Developmental Biology. 355(1):55-64
Gongal, P.A., French, C.R., and Waskiewicz, A.J. (2011) Aberrant forebrain signaling during early development underlies the generation of holoprosencephaly and coloboma. Biochimica et biophysica acta. Molecular basis of disease. 1812(3):390-401
Erickson, T., French, C.R., and Waskiewicz, A.J. (2010) Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Development. 5:22
Pillay, L.M., Forrester, A.M., Erickson, T., Berman, J.N., and Waskiewicz, A.J. (2010) The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Developmental Biology. 340(2):306-317
Ye, M., Berry-Wynne, K.M., Asai-Coakwell, M., Sundaresan, P., Footz, T., French, C.R., Abitbol, M., Fleisch, V.C., Corbett, N., Allison, W.T., Drummond, G., Walter, M.A., Underhill, T.M., Waskiewicz, A.J., and Lehmann, O.J. (2010) Mutation of the Bone Morphogenetic Protein GDF3 causes ocular and skeletal anomalies. Human molecular genetics. 19(2):287-298
French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J. (2009) Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development. Developmental Biology. 333(1):37-47
Asai-Coakwell, M., French, C.R., Ye, M., Garcha, K., Bigot, K., Perera, A.G., Staehling-Hampton, K., Mema, S.C., Chanda, B., Mushegian, A., Bamforth, S., Doschak, M.R., Li, G., Dobbs, M.B., Giampietro, P.F., Brooks, B.P., Vijayalakshmi, P., Sauvé, Y., Abitbol, M., Sundaresan, P., Heyningen, V.V., Pourquié, O., Underhill, T.M., Waskiewicz, A.J., and Lehmann, O.J. (2009) Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes. Human molecular genetics. 18(6):1110-1121
Gongal, P.A., and Waskiewicz, A.J. (2008) Zebrafish model of Holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. Human molecular genetics. 17(4):525-538
Hanington, P.C., Patten, S.A., Reaume, L.M., Waskiewicz, A.J., Belosevic, M., and Ali, D.W. (2008) Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio). Developmental Biology. 314(2):250-260
Kohli, V., Robles, V., Cancela, M.L., Acker, J.P., Waskiewicz, A.J., and Elezzabi, A.Y. (2007) An alternative method for delivering exogenous material into developing zebrafish embryos. Biotechnology and Bioengineering. 98(6):1230-1241
Maves, L., Waskiewicz, A.J., Paul, B., Cao, Y., Tyler, A., Moens, C.B., and Tapscott, S.J. (2007) Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development (Cambridge, England). 134(18):3371-3382
French, C.R., Erickson, T., Callander, D., Berry, K.M., Koss, R., Hagey, D.W., Stout, J., Wuennenberg-Stapleton, K., Ngai, J., Moens, C.B., and Waskiewicz, A.J. (2007) Pbx homeodomain proteins pattern both the zebrafish retina and tectum. BMC Developmental Biology. 7(1):85
Asai-Coakwell, M., French, C.R., Berry, K.M., Ye, M., Koss, R., Somerville, M., Mueller, R., van Heyningen, V., Waskiewicz, A.J., and Lehmann, O.J. (2007) GDF6, a novel locus for a spectrum of ocular developmental anomalies. American journal of human genetics. 80(2):306-315
Erickson, T., Scholpp, S., Brand, M., Moens, C.B., and Waskiewicz, A. Jan (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology. 301(2):504-517
Lukowski, C.M., Ritzel, R.G., and Waskiewicz, A.J. (2006) Expression of two insm1-like genes in the developing zebrafish nervous system. Gene expression patterns : GEP. 6(7):711-718
Manning, A.G., Crawford, B.D., Waskiewicz, A.J., and Pilgrim, D.B. (2004) UNC-119 homolog required for normal development of the zebrafish nervous system. Genesis (New York, N.Y. : 2000). 40(4):223-230
Waskiewicz, A.J., Rikhof, H.A., and Moens, C.B. (2002) Eliminating zebrafish Pbx proteins reveals a hindbrain ground state. Developmental Cell. 3(5):723-733
Waskiewicz, A.J., Rikhof, H.A., Hernandez, R.E., and Moens, C.B. (2001) Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development (Cambridge, England). 128(21):4139-4151
Moens, C.B., Pöpperl, H., Waskiewicz, A., and Rikhof, H. (2001) Genetic control of hindbrain patterning in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A714

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