ZFIN ID: ZDB-PERS-980413-717
Shepherd, Iain T.
Email: ishephe@emory.edu
URL: http://www.emory.edu/BIOLOGY/ishephe/
Affiliation: Shepherd Lab
Address: Department of Biology Emory University Rollins Research Building 1510 Clifton Road Atlanta, GA 30322 USA
Country: United States
Phone: (404) 727-6292
Fax: (404) 727-2880
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Enteric nervous system development.


PUBLICATIONS
Sribudiani, Y., Chauhan, R.K., Alves, M.M., Petrova, L., Brosens, E., Harrison, C., Wabbersen, T., de Graaf, B.M., Rügenbrink, T., Burzynski, G., Brouwer, R.W.W., IJcken, W.F.J.V., Maas, S.M., de Klein, A., Osinga, J., Eggen, B.J.L., Burns, A.J., Brooks, A.S., Shepherd, I.T., Hofstra, R.M.W. (2018) Identification of Variants in RET and IHH Pathway Members in a Large Family With History of Hirschsprung Disease. Gastroenterology. 155(1):118-129.e6
Gui, H., Schriemer, D., Cheng, W.W., Chauhan, R.K., Antiňolo, G., Berrios, C., Bleda, M., Brooks, A.S., Brouwer, R.W., Burns, A.J., Cherny, S.S., Dopazo, J., Eggen, B.J., Griseri, P., Jalloh, B., Le, T.L., Lui, V.C., Luzón-Toro, B., Matera, I., Ngan, E.S., Pelet, A., Ruiz-Ferrer, M., Sham, P.C., Shepherd, I.T., So, M.T., Sribudiani, Y., Tang, C.S., van den Hout, M.C., van der Linde, H.C., van Ham, T.J., van IJcken, W.F., Verheij, J.B., Amiel, J., Borrego, S., Ceccherini, I., Chakravarti, A., Lyonnet, S., Tam, P.K., Garcia-Barceló, M.M., Hofstra, R.M. (2017) Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome biology. 18:48
Heanue, T.A., Shepherd, I.T., Burns, A.J. (2016) Enteric Nervous System Development in Avian and Zebrafish Models. Developmental Biology. 417(2):129-38
Uyttebroek, L., Shepherd, I.T., Vanden Berghe, P., Hubens, G., Timmermans, J.P., Van Nassauw, L. (2016) The zebrafish mutant lessen: an experimental model for congenital enteric neuropathies. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(3):345-57
Harrison, C., Wabbersen, T., Shepherd, I. (2014) In Vivo Visualization of the Development of the Enteric Nervous System Using a Tg(-8.3bphox2b:Kaede) Transgenic Zebrafish. Genesis (New York, N.Y. : 2000). 52(12):985-90
Uyttebroek, L., Shepherd, I.T., Hubens, G., Timmermans, J.P., and Van Nassauw, L. (2013) Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells. Cell and tissue research. 354(2):355-70
Werf, C.S., Wabbersen, T.D., Hsiao, N.H., Paredes, J., Etchevers, H.C., Kroisel, P.M., Tibboel, D., Babarit, C., Schreiber, R.A., Hoffenberg, E.J., Vekemans, M., Zeder, S.L., Ceccherini, I., Lyonnet, S., Ribeiro, A.S., Seruca, R., Te Meerman, G.J., van Ijzendoorn, S.C., Shepherd, I.T., Verheij, J.B., and Hofstra, R.M. (2012) CLMP Is Required for Intestinal Development, and Loss-of-Function Mutations Cause Congenital Short-Bowel Syndrome. Gastroenterology. 142(3):453-462
Shepherd, I., and Eisen, J. (2011) Development of the zebrafish enteric nervous system. Methods in cell biology. 101:143-160
Uyttebroek, L., Shepherd, I.T., Harrisson, F., Hubens, G., Blust, R., Timmermans, J.P., and Van Nassauw, L. (2010) Neurochemical coding of enteric neurons in adult and embryonic zebrafish (Danio rerio). The Journal of comparative neurology. 518(21):4419-4438
Alves, M.M., Burzynski, G., Delalande, J.M., Osinga, J., van der Goot, A., Dolga, A.M., de Graaff, E., Brooks, A.S., Metzger, M., Eisel, U.L., Shepherd, I., Eggen, B.J., and Hofstra, R.M. (2010) KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Human molecular genetics. 19(18):3642-3651
Schlager, M.A., Kapitein, L.C., Grigoriev, I., Burzynski, G.M., Wulf, P.S., Keijzer, N., de Graaff, E., Fukuda, M., Shepherd, I.T., Akhmanova, A., and Hoogenraad, C.C. (2010) Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. The EMBO journal. 29(10):1637-1651
Kok, F.O., Shepherd, I.T., and Sirotkin, H.I. (2010) Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 239(2):548-558
D'Costa, A., and Shepherd, I.T. (2009) Zebrafish development and genetics: introducing undergraduates to developmental biology and genetics in a large introductory laboratory class. Zebrafish. 6(2):169-177
Burzynski, G.M., Delalande, J.M., and Shepherd, I. (2009) Characterization of spatial and temporal expression pattern of SCG10 during zebrafish development. Gene expression patterns : GEP. 9(4):231-237
de Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H., Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T., Nixon, S.J., Parton, R.G., Zon, L.I., Stainier, D.Y., Lieschke, G.J., and Heath, J.K. (2009) Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology. 136(3):902-911
Burzynski, G., Shepherd, I.T., and Enomoto, H. (2009) Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 21(2):113-127
Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T. (2008) Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Developmental Biology. 318(1):52-64
Delalande, J.M., Guyote, M.E., Smith, C.M., and Shepherd, I.T. (2008) Zebrafish sip1a and sip1b are essential for normal axial and neural patterning. Developmental dynamics : an official publication of the American Association of Anatomists. 237(4):1060-1069
Suli, A., Mortimer, N., Shepherd, I., and Chien, C.B. (2006) Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(51):13328-13337
Durr, K., Holzschuh, J., Filippi, A., Ettl, A.K., Ryu, S., Shepherd, I.T., and Driever, W. (2006) Differential Roles of Transcriptional Mediator Complex Subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 During Zebrafish Retinal Development. Genetics. 174(2):693-705
Grimes, A.C., Stadt, H.A., Shepherd, I.T., and Kirby, M.L. (2006) Solving an enigma: Arterial pole development in the zebrafish heart. Developmental Biology. 290(2):265-276
Pietsch, J., Delalande, J.M., Jakaitis, B., Stensby, J.D., Dohle, S., Talbot, W.S., Raible, D.W., and Shepherd, I.T. (2006) lessen encodes a zebrafish trap100 required for enteric nervous system development. Development (Cambridge, England). 133(3):395-406
Shepherd, I.T., Pietsch, J., Elworthy, S., Kelsh, R.N., and Raible, D.W. (2004) Roles for GFRalpha1 receptors in zebrafish enteric nervous system development. Development (Cambridge, England). 131(1):241-249
Shepherd, I.T., Beattie, C.E., and Raible, D.W. (2001) Functional analysis of zebrafish GDNF. Developmental Biology. 231(2):420-435

NON-ZEBRAFISH PUBLICATIONS