ZFIN ID: ZDB-PERS-980323-2
Maves, Lisa
Email: lmaves@u.washington.edu
URL: http://depts.washington.edu/cdbrm/wordpress/research-labs-center-for-developmental-biology-and-regenerative-medicine/maves-lab/
Affiliation: Maves Lab
Address: Seattle Children's Research Institute 1900 Ninth Avenue, JMB-5 Seattle, Washington 98101 USA
Country: United States
Phone: (206) 884-1052
Fax: (206) 884-1407
ORCID ID: 0000-0002-9798-790X

My lab uses the zebrafish model to understand cellular differentiation during cardiac and skeletal muscle development, with the goal of understanding the mechanisms behind congenital heart defects and muscular dystrophy. We are driven by the beauty of the zebrafish embryo as well as the capacity for zebrafish to inform human development and disease. We use Duchenne muscular dystrophy (dmd) zebrafish to identify novel epigenetic drugs that ameliorate DMD as well as to help characterize mechanisms of epigenetic dysregulation in DMD. We also apply our expertise in using CRISPR to study gene knock-outs of new human congenital heart disease loci in zebrafish.

Farr, G.H., Morris, M., Gomez, A., Pham, T., Kilroy, E., Parker, E.U., Said, S., Henry, C., Maves, L. (2020) A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skeletal muscle. 10:29
Maves, L. (2020) Special Issue "Zebrafish-A Model System for Developmental Biology Study". Journal of developmental biology. 8(3)
Farr, G.H., Imani, K., Pouv, D., Maves, L. (2018) Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects.. Disease models & mechanisms. 11(10):
Row, R.H., Pegg, A., Kinney, B., Farr, G.H., Maves, L., Lowell, S., Wilson, V., Martin, B.L. (2018) BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLIFE. 7
Patton, C., Farr, G.H., An, D., Martini, P.G.V., Maves, L. (2018) Lipid Nanoparticle Packaging Is an Effective and Nontoxic mRNA Delivery Platform in Embryonic Zebrafish. Zebrafish. 15(3):217-227
Goody, M.F., Carter, E.V., Kilroy, E.A., Maves, L., Henry, C.A. (2017) "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish. Current topics in developmental biology. 124:197-234
Kao, R.M., Rurik, J.G., Farr, G.H., Dong, X.R., Majesky, M.W., Maves, L. (2015) Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation. Journal of developmental biology. 3:93-111
Maves, L. (2014) Recent advances using zebrafish animal models for muscle disease drug discovery. Expert opinion on drug discovery. 9(9):1033-45
Smith, J.D., Hing, A.V., Clarke, C.M., Johnson, N.M., Perez, F.A., Park, S.S., Horst, J.A., Mecham, B., Maves, L., Nickerson, D.A., University of Washington Center for Mendelian Genomics, Cunningham, M.L. (2014) Exome Sequencing Identifies a Recurrent De Novo ZSWIM6 Mutation Associated with Acromelic Frontonasal Dysostosis. American journal of human genetics. 95:235-240
Johnson, N.M., Farr, G.H., and Maves, L. (2013) The HDAC Inhibitor TSA Ameliorates a Zebrafish Model of Duchenne Muscular Dystrophy. PLoS Currents. 5:157-71
Yao, Z., Farr, G.H., Tapscott, S.J., and Maves, L. (2013) Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish. Biology Open. 2(6):546-555
Paige, S.L., Thomas, S., Stoick-Cooper, C.L., Wang, H., Maves, L., Sandstrom, R., Pabon, L., Reinecke, H., Pratt, G., Keller, G., Moon, R.T., Stamatoyannopoulos, J., and Murry, C.E. (2012) A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development. Cell. 151(1):221-232
Maves, L., Tyler, A., Moens, C.B., and Tapscott, S.J. (2009) Pbx acts with Hand2 in early myocardial differentiation. Developmental Biology. 333(2):409-418
Sittaramane, V., Sawant, A., Wolman, M.A., Maves, L., Halloran, M.C., and Chandrasekhar, A. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Developmental Biology. 325(2):363-373
Maves, L., Waskiewicz, A.J., Paul, B., Cao, Y., Tyler, A., Moens, C.B., and Tapscott, S.J. (2007) Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development (Cambridge, England). 134(18):3371-3382
Maves, L., and Kimmel, C.B. (2005) Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Developmental Biology. 285(2):593-605
Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716
Miller, C.T., Maves, L., and Kimmel, C.B. (2004) moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Development (Cambridge, England). 131(10):2443-2461
Liu, D., Chu, H., Maves, L., Yan, Y.-L., Morcos, P.A., Postlethwait, J.H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development (Cambridge, England). 130(10):2213-2224
Maves, L., Jackman, W., and Kimmel, C.B. (2002) FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development (Cambridge, England). 129:3825-3837
Maves, L. and Kimmel, C.B. (2002) Dual roles for FGF signaling in promoting zebrafish hindbrain development. Developmental Biology. 247(2):480-481