ZFIN ID: ZDB-PERS-970313-6
Cooke, Julie E.
Email: julie.cooke@summitplc.com
URL: http://www.summitplc.com
Address: Summit plc 91 Milton Park Abingdon, Oxfordshire, OX14 4RY United Kingdom
Phone: +44 (0) 1235 443 941
Fax: +44 (0) 1235 443 999

Summit plc specialises in Chemical Genomics. Please visit our website (http://www.summitplc.com) for further information.
Before I joined Summit plc I co-ordinated the zebrafish laboratory work in Greg Elgar's Comparative Genomics Group at the MRC RFCGR, Hinxton, UK. We were analysing the function of highly Conserved Non-coding Elements (CNEs) using a transient transgenic approach in zebrafish.
Previously I worked in Cecilia Moens' lab at the Fred Hutchinson Cancer Research Center in Seattle, WA, USA and in Nigel Holder's and Steve Wilson's labs at King's College and University College London. I studied the roles of Eph signalling during development, particularly in hindbrain segmentation, mechanisms of segmentation and boundary formation during hindbrain development and the role of segmentation in hindbrain patterning.

Kemp, H.A., Cooke, J.E., and Moens, C.B. (2009) EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel. Developmental Biology. 327(2):313-326
Woolfe, A., Goode, D.K., Cooke, J., Callaway, H., Smith, S., Snell, P., McEwen, G.K., and Elgar, G. (2007) CONDOR: a database resource of developmentally associated conserved non-coding elements. BMC Developmental Biology. 7(1):100
Goode, D.K., Snell, P., Smith, S.F., Cooke, J.E., and Elgar, G. (2005) Highly conserved regulatory elements around the SHH gene may contribute to the maintenance of conserved synteny across human chromosome 7q36.3. Genomics. 86(2):172-181
Cooke, J.E., Kemp, H.A., and Moens, C.B. (2005) EphA4 Is Required for Cell Adhesion and Rhombomere-Boundary Formation in the Zebrafish. Current biology : CB. 15(6):536-542
Woolfe, A., Goodson, M., Goode, D.K., Snell, P., McEwen, G.K., Vavouri, T., Smith, S.F., North, P., Callaway, H., Kelly, K., Walter, K., Abnizova, I., Gilks, W., Edwards, Y.J., Cooke, J.E., and Elgar, G. (2005) Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biology. 3(1):e7
Cooke, J.E. and Moens, C.B. (2002) Boundary formation in the hindbrain: Eph only it were simple. Trends in neurosciences. 25(5):260-267
Cooke, J.E., Moens, C.B., Roth, L.W., Durbin, L., Shiomi, K., Brennan, C., Kimmel, C.B., Wilson, S.W., and Holder, N. (2001) Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development (Cambridge, England). 128(4):571-580
Durbin, L., Brennan, C., Shiomi, K., Cooke, J., Barrios, A., Shanmugalingam, S., Guthrie, B., Lindberg, R., and Holder, N. (1998) Eph signaling is required for segmentation and differentiation of the somites. Genes & Development. 12:3096-3109
Cooke, J.E., Xu, Q.L., Wilson, S.W., and Holder, N. (1997) Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate. Development genes and evolution. 206:515-531
Holder, N., Brennan, C., Cooke, J., Durbin, L., and Qiling, X. (1996) The role of signalling through Eph receptors in patterning the zebrafish neural plate. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14:59

Cooke JE, Heasman J, Wylie CC. The role of interleukin-4 in the regulation of mouse primordial germ cell numbers. Dev Biol 1996 Feb 25;174(1):14-21

Cooke JE, Godin I, Ffrench-Constant C, Heasman J, Wylie CC. Culture and manipulation of primordial germ cells. Methods Enzymol 1993; 225:37-58

Godin I, Deed R, Cooke J, Zsebo K, Dexter M, Wylie CC. Effects of the steel gene product on mouse primordial germ cells in culture. Nature 1991 Aug 29;352(6338):807-809