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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-673
Cheng, Keith C.
Email: kcheng@psu.edu
URL: http://profiles.psu.edu/profiles/display/113446
Affiliation: Cheng Lab
Address: The Jake Gittlen Cancer Research Institute Hershey Medical Center Pennsylvania State University College of Medicine 500 University Drive Hershey, PA 17033 USA
Country: United States
Phone: Office: (717) 531-5635, Lab: (717) 531-4704
Fax: (717) 531-5634
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Genomic instability, cellular differentiation, cancer, zebrafish functional genomics, anatomic atlas, and virtual microscopy.


PUBLICATIONS
Ding, Y., Vanselow, D.J., Yakovlev, M.A., Katz, S.R., Lin, A.Y., Clark, D.P., Vargas, P., Xin, X., Copper, J.E., Canfield, V.A., Ang, K.C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D.B., La Riviere, P., Cheng, K. (2019) Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. eLIFE. 8:
Lin, A.Y., Ding, Y., Vanselow, D.J., Katz, S.R., Yakovlev, M.A., Clark, D.P., Mandrell, D., Copper, J.E., van Rossum, D.B., Cheng, K.C. (2018) Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography. Journal of visualized experiments : JoVE. (140)
Copper, J.E., Budgeon, L.R., Foutz, C.A., van Rossum, D.B., Vanselow, D.J., Hubley, M.J., Clark, D.P., Mandrell, D.T., Cheng, K.C. (2017) Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 208:38-46
Cheng, K.C., Katz, S.R., Lin, A.Y., Xin, X., Ding, Y. (2016) Whole-Organism Cellular Pathology: A Systems Approach to Phenomics. Advances in genetics. 95:89-115
Tsetskhladze, Z.R., Canfield, V.A., Ang, K.C., Wentzel, S.M., Reid, K.P., Berg, A.S., Johnson, S.L., Kawakami, K., and Cheng, K.C. (2012) Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS One. 7(10):e47398
Cheng, K.C., Xin, X., Clark, D.P., and La Riviere, P. (2011) Whole-animal imaging, gene function, and the Zebrafish Phenome Project. Current opinion in genetics & development. 21(5):620-9
Canada, B.A., Thomas, G.K., Cheng, K.C., and Wang, J.Z. (2011) SHIRAZ: an automated histology image annotation system for zebrafish phenomics. Multimedia Tools and Applications. 51(2):401-440
Ekker, S.C., Parichy, D.M., and Cheng, K.C. (2008) Research implications of pigment biology in zebrafish. Zebrafish. 5(4):233-235
Aleström, P., Begemann, G., Carvan, M.J. 3rd, Cheng, K.C., Crosier, K., Crosier, P., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G., Mione, M., Neely, M.N., Neuhauss, S., and Trede, N.S. (2008) Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24
Moore, J.L., Rush, L.M., Breneman, C., Mohideen, M.A., and Cheng, K.C. (2006) Zebrafish Genomic Instability Mutants and Cancer Susceptibility. Genetics. 174(2):585-600
Sabaliauskas, N.A., Foutz, C.A., Mest, J.R., Budgeon, L.R., Sidor, AT, Gershenson, J.A., Joshi, S.B., and Cheng, K.C. (2006) High-throughput zebrafish histology. Methods (San Diego, Calif.). 39(3):246-254
Blasiole, B., Canfield, V.A., Vollrath, M.A., Huss, D., Mohideen, M.A., Dickman, J.D., Cheng, K.C., Fekete, D.M., and Levenson, R. (2006) Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Developmental Biology. 294(1):148-160
Canada, B.A., Cheng, K.C., and Wang, J.Z. (2006) QCHARM: A Novel Computational and Scientific Visualization Framework for Facilitating Discovery and Improving Diagnostic Reliability in Medicine. AMIA Annual Symposium proceedings. :870
Lamason, R.L., Mohideen, M.A., Mest, J.R., Wong, A.C., Norton, H.L., Aros, M.C., Jurynec, M.J., Mao, X., Humphreville, V.R., Humbert, J.E., Sinha, S., Moore, J.L., Jagadeeswaran, P., Zhao, W., Ning, G., Makalowska, I., McKeigue, P.M., O'donnell, D., Kittles, R., Parra, E.J., Mangini, N.J., Grunwald, D.J., Shriver, M.D., Canfield, V.A., and Cheng, K.C. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (New York, N.Y.). 310(5755):1782-1786
Croushore, J.A., Blasiole, B., Riddle, R.C., Thisse, C., Thisse, B., Canfield, V.A., Robertson, G.P., Cheng, K.C., and Levenson, R. (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 234(4):911-921
Duffy, K.T., McAleer, M.F., Davidson, W.R., Kari, L., Kari, C., Liu, C.G., Farber, S.A., Cheng, K.C., Mest, J.R., Wickstrom, E., Dicker, A.P., and Rodeck, U. (2005) Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Nucleic acids research. 33(15):4914-4921
Gerhard, G.S., Malek, R.L., Keller, E., Murtha, J., and Cheng, K.C. (2004) Zebrafish, Killifish, Neither Fish, Both Fish?. The journals of gerontology. Series A, Biological sciences and medical sciences. 59(9):B873-B875
Moore, J.L., Gestl, E.E., and Cheng, K.C.. (2004) Mosaic eyes, genomic instability mutants, and cancer susceptibility. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:555-568
Cheng, K.C., Levenson, R., and Robishaw, J.D. (2003) Functional genomic dissection of multimeric protein families in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):555-567
Mohideen, M.A., Beckwith, L.G., Tsao-Wu, G.S., Moore, J.L., Wong, A.C., Chinoy, M.R., and Cheng, K.C. (2003) Histology-based screen for zebrafish mutants with abnormal cell differentiation. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):414-423
Gerhard, G.S. and Cheng, K.C. (2002) A call to fins! Zebrafish as a gerontological model. Aging Cell. 1(2):104-111
Gerhard, G., Kauffman, E., Wang, X., Stewart, R., Moore, J., Kasales, C., Demidenko, E., and Cheng, K. (2002) Life spans and senescent phenotypes in two strains of zebrafish (Danio rerio). Experimental gerontology. 37(8-9):1055-1068
Clarke, L.E., Cheng, K., Beckwith, L.G., Moore, J.L., Wang, X., and Boyer, P.J. (2002) Expression in adult zebrafish of antigens detected by immunomarkers commonly used in diagnostic pathology laboratories: Prelude to evaluation of spontaneously arising and induced neoplasms. Journal of neuropathology and experimental neurology. 61(5):112
Moore, J.L., Aros, M., Steudel, K.G., and Cheng, K.C. (2002) Fixation and decalcification of adult zebrafish for histological, immunocytochemical, and genotypic analysis. Biotechniques. 32(2):296-298
Rajarao, S.J., Canfield, V.A., Mohideen, M.A., Yan, Y.-L., Postlethwait, J.H., Cheng, K.C., and Levenson, R. (2001) The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome research. 11(7):1211-1220
Mohideen, M.A.P.K., Moore, J.L., and Cheng, K.C. (2000) Centromere-linked microsatellite markers for linkage groups 3, 4, 6, 7, 13, and 20 of zebrafish (Danio rerio). Genomics. 67(1):102-106
Beckwith, L.G., Moore, J.L., Tsao-Wu, G.S., Harshbarger, J.C., and Cheng, K.C. (2000) Ethylnitrosourea induces neoplasia in zebrafish (Danio rerio). Laboratory investigation; a journal of technical methods and pathology. 80(3):379-385
Tsao-Wu, G.S., Weber, C.H., Budgeon, L.R., and Cheng, K.C. (1998) Agarose-embedded tissue arrays for histologic and genetic analysis. Biotechniques. 25:614-618
Gestl, E.E., Kauffman, E.J., Moore, J.L., and Cheng, K.C. (1997) New conditions for generation of gynogenetic half-tetrad embryos in the zebrafish (Danio rerio). The Journal of heredity. 88(1):76-79
Cheng, K.C. and Moore, J.L. (1997) Genetic dissection of vertebrate processes in zebrafish: A comparison of uniparental and two-generation screens. Biochemistry and cell biology = Biochimie et biologie cellulaire. 75:525-533
Kauffman, E.J., Gestl, E.E., Kim, D.J., Walker, C., Hite, J.M., Yan, G., Rogan, P.K., Johnson, S.L., and Cheng, K.C. (1995) Microsatellite-centromere mapping in the zebrafish (Danio rerio). Genomics. 30:337-341
Ham, P.H. and Cheng, K.C. (1995) Construction of zebrafish spawning cages. Zebrafish Science Monitor. 3:5
Gestl, E.E. and Cheng, K.C. (1995) A small zebrafish genetics facility. Zebrafish Science Monitor. 3:6-8
Cheng, K.C., E.J. Kauffman, and E. Gestl (1993) Tidbits (nibbles) on raising zebrafish babies. Zebrafish Science Monitor. 2:3,6

NON-ZEBRAFISH PUBLICATIONS
Cheng, K.C. and Smith, G.R. (1984) Recombinational hotspot activity of Chi-like sequences. J. Mol. Biol. 180:371-377.

Smith, G.R., Amundsen, S.K., Chaudhury, A.M., Cheng, K.C., Ponticelli, A.S., Roberts, C.M., Schultz, D.W. and Taylor, A.F. (1984) Roles of RecBC enzyme and Chi sites in homologous recombination. Cold Spring Harbor Symp. Quant. Biol. 49:485-495.

Smith, G.R., Amundsen, S.K., Cheng, K.C., McKittrick, N.H., Ponticelli, A.S., Roberts, C.M., Schultz, D.W. , Taylor, A.F. and Thibodeaux, S. (1987) Mechanism and control of homologous recombination. In Mechanisms of DNA replication and recombination. UCLA Symposium on Molecular and Cellular Biology New Series, Volume 47. Alan R. Liss, Inc. New York, New York, pages 567-583.

Cheng, K.C. and Smith G.R. (1987) Cutting of Chi-like sequences by RecBCD enzyme. J. Mol. Biol. 194:747-750.

Cheng, K.C. and Smith, G.R. (1989) Distribution of Chi-stimulated recombinational exchanges and heteroduplex endpoints in phage lambda. Genetics 123:5-17.

Loeb, L.A. and Cheng, K.C. (1990) Errors in DNA synthesis: A source of spontaneous mutations. Mutat. Res. 238:297-304.

Cheng, K.C. and Dias, M. (1991) Genomic Instability and Cancer: Cause and Effect (invited Keystone Meeting review) Cancer Cells 3:188-192.

Loeb, L.A., McBride, T.J ., Reid, T.M. and Cheng, K.C. (1991) Mutagenic spectra of oxygen free radicals. In New Horizons in Molecular Toxicology, pp. 35-39, eds., G.S. Probst, J.J. Vodicnik and M.A. Dorato, published for Lilly Research Laboratories by FASEB, 1991.

Cheng, K.C., Cahill, D.S., Preston, B.D., Singer, B. and Loeb, L.A. (1991) The vinyl chloride DNA derivative, N2,3-ethenoguanine, causes G to A transitions in E. coli. Proc. Natl. Acad. Sci., U.S.A. 88:9974-9978.

Cheng, K.C., Cahill, D.S., Kasai, Nishimura, S. and Loeb, L.A. (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J. Biol. Chem. 267:166-172.

Cheng, K.C. and Loeb, L.A. (1993) Genomic Instability and tumor progression: mechanistic considerations. Advances in Cancer Research 60:121-156.

Cheng, K.C. and Loeb, L.A. (1996) Genomic stability and instability: A working paradigm. Chapter 2, Current Topics in Microbiology and Immunology, (ed. M.B. Kastan) Springer-Verlag, Berlin, pp. 5-18.

Hite, J.M., Eckert, K.E., Kauffman, E.J., and Cheng, K.C. (1996) Factors affecting fidelity of DNA synthesis during PCR amplification of d(CA)n@d(G-T)n microsatellite repeats. Nucleic Acids Res. 24:2429-2434.

Cheng, K.C. (1998) "A Day Well Spent for Science: a First Experience with Scientific Congressional Advocacy", The ASCB Newsletter, Vol. 21, No. 3 (April 1998).

Cheng, K. (1998) You can't win the Indy 500 in a Yugo: Help NSF funding: An oped. In HMS Beagle: The BioMedNet Magazine (http://biomednet.com/hmsbeagle/1998/28/people/op_ed.htm) Issue 28 (Apr. 17)