ZFIN Person: Lele, Zsolt

ZFIN ID: ZDB-PERS-960805-327

ZFIN ID: ZDB-PERS-960805-327

Lele, Zsolt

Email:	z.lele@ucl.ac.uk
URL:
Affiliation:
Address:	Department of Anatomy and Developmetal Biology University College London Gower Street London, WC1E 6BT United Kingdom
Country:
Phone:	44-20-76793330
Fax:	44-20-76797349
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My main interests are cell-cell adhesion, cell migration and morphogenetic events during zebrafish development. More specifically I am working on analysing the function of heparan-sulfate proteoglycans and classic cadherins and their possible roles as modifiers of various signalling pathways in these cellular processes.

PUBLICATIONS

Hawkins, T.A., Cavodeassi, F., Erdelyi, F., Szabo, G., and Lele, Z. (2008) The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish. BMC Developmental Biology. 8(1):42

Hadzhiev, Y., Lele, Z., Schindler, S., Wilson, S.W., Ahlberg, P., Straehle, U., and Mueller, F. (2007) Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Developmental Biology. 7(1):75

Mione, M., Lele, Z., Kwong, C.T., Concha, M.L., and Clarke, J.D. (2006) Expression of pcp4a in subpopulations of CNS neurons in zebrafish. The Journal of comparative neurology. 495(6):769-787

Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658

Bink, R.J., Habuchi, H., Lele, Z., Dolk, E., Joore, J., Rauch, G.J., Geisler, R., Wilson, S.W., den Hertog, J., Kimata, K., and Zivkovic, D. (2003) Heparan sulfate 6-O-sulfotransferase is essential for muscle development in zebrafish. The Journal of biological chemistry. 278(33):31118-31127

Masai, I., Lele, Z., Yamaguchi, M., Komori, A., Nakata, A., Nishiwaki, Y., Wada, H., Tanaka, H., Nojima, Y., Hammerschmidt, M., Wilson, S.W., and Okamoto, H. (2003) N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites. Development (Cambridge, England). 130(11):2479-2494

Herzog, W., Zeng, X., Lele, Z., Sonntag, C., Ting, J.W., Chang, C.Y., and Hammerschmidt, M. (2003) Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog. Developmental Biology. 254(1):36-49

Lele, Z., Folchert, A., Concha, M., Rauch, G.-J., Geisler, R., Rosa, F., Wilson, S.W., Hammerschmidt, M., and Bally-Cuif, L. (2002) parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Development (Cambridge, England). 129(14):3281-3294

Lele, Z., Nowak, M., and Hammerschmidt, M. (2001) Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):681-687

Topczewski, J., Sepich, D.S., Myers, D.C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Developmental Cell. 1(2):251-264

Lele, Z., Bakkers, J., and Hammerschmidt, M. (2001) Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations. Genesis (New York, N.Y. : 2000). 30(3):190-194

Bauer, H., Lele, Z., Rauch, G.J., Geisler, R., and Hammerschmidt, M. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development (Cambridge, England). 128(6):849-858

Halloran, M.C., Sato-Maeda, M., Warren, J.T., Su, F., Lele, Z., Krone, P.H., Kuwada, J.Y., and Shoji, W. (2000) Laser-induced gene expression in specific cells of transgenic zebrafish. Development (Cambridge, England). 127(9):1953-1960

Adam, A., Bartfai, R., Lele, Z., Krone, P.H., and Orbán, L. (2000) Heat-inducible expression of a reporter gene detected by transient assay in zebrafish. Experimental cell research. 256(1):282-290

Lele, Z., Hartson, S.D., Martin, C.C., Whitesell, L., Matts, R.L., and Krone, P.H. (1999) Disruption of zebrafish somite development by pharmacologic inhibition of hsp90. Developmental Biology. 210(1):56-70

Lele, Z. (1998) Expression, regulation and possible function of heat shock genes (hsp47, hsp70, hsp90(alpha) and hsp90(beta)) during normal development and under stress-conditions in zebrafish (cell differentiation, notochords). Ph.D. Thesis.

Lele, Z. and Krone, P.H. (1997) Expression of genes encoding the collegen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos. Mechanisms of Development. 61(1-2):89-98

Krone, P.H., Sass, J.B., and Lele, Z. (1997) Heat shock protein gene expression during embryonic development of the zebrafish. Cellular and molecular life sciences : CMLS. 53(1):122-129

Lele, Z., S. Engel, and P.H. Krone (1997) hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos. Developmental genetics. 21(2):123-133

Krone, P.H., Lele, Z., and Sass, J.B. (1997) Heat shock genes and the heat shock response in zebrafish embryos. Biochemistry and cell biology = Biochimie et biologie cellulaire. 75:487-497

Lele, Z. and Krone, P.H. (1996) The zebrafish as a model system in developmental, toxicological and transgenic research. Biotech. Adv.. 14:57-72

Müller, F., Lele, Z., Varadi, L., Menczel, L., and Orbán, L. (1993) Efficient transient expression system based on square pulse electroporation and in vivo luciferase assay of fertilized fish eggs. FEBS letters. 324:27-32

NON-ZEBRAFISH PUBLICATIONS
A. Ficzycz, N. K. Kaludov, Z. Lele, M. M. Hurt and N. Ovsenek
A conserved element in the protein-coding sequence is required for normal expression of replication-dependent histone genes in developing Xenopus embryos. Dev. Biol. 182: 21-32, 1997