ZFIN Person: Okuda, Kazuhide Shaun

ZFIN ID: ZDB-PERS-150713-1

Okuda, Kazuhide Shaun

Email:	kazuhideshaun.okuda@petermac.org
URL:	https://scholar.google.com/citations?user=HvKo1eMAAAAJ&hl=en
Affiliation:	Hogan Lab
Address:	Organogenesis and Cancer Program Peter MacCallum Cancer Centre 305 Grattan St Melbourne VIC 3000
Country:	Australia
Phone:	+61 7 3346 2222
Fax:	+61 7 3346 2101
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Vascular Biology
Lymphatic
Disease Models
Cancer

PUBLICATIONS

Leong, S.W., Wang, J., Okuda, K.S., Su, Q., Zhang, Y., Abas, F., Chia, S.L., Yusoff, K. (2023) Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells. European Journal of Medicinal Chemistry. 254:115335115335

Koltowska, K., Okuda, K.S., Gloger, M., Rondon-Galeano, M., Mason, E., Xuan, J., Dudczig, S., Chen, H., Arnold, H., Skoczylas, R., Bower, N.I., Paterson, S., Lagendijk, A.K., Baillie, G.J., Leshchiner, I., Simons, C., Smith, K.A., Goessling, W., Heath, J.K., Pearson, R.B., Sanij, E., Schulte-Merker, S., Hogan, B.M. (2021) The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nature cell biology. 23:1136-1147

Okuda, K.S., Ng, M.F., Ruslan, N.F., Bower, N.I., Song, D.S.S., Chen, H., Baek, S., Crosier, P.S., Koltowska, K., Astin, J.W., Tan, P.J., Hogan, B.M., Patel, V. (2021) 3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish. Pharmaceuticals (Basel, Switzerland). 14(7):

Okuda, K.S., Keyser, M.S., Gurevich, D.B., Sturtzel, C., Mason, E.A., Paterson, S., Chen, H., Scott, M., Condon, N.D., Martin, P., Distel, M., Hogan, B.M. (2021) Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis. eLIFE. 10:

Chaudhury, S., Okuda, K.S., Koltowska, K., Lagendijk, A.K., Paterson, S., Baillie, G.J., Simons, C., Smith, K.A., Hogan, B.M., Bower, N.I. (2020) Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo. Development (Cambridge, England). 147(18):

Okuda, K.S., Hogan, B.M. (2020) Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish. Frontiers in Physiology. 11:842

Vogrin, A.J., Bower, N.I., Gunzburg, M.J., Roufail, S., Okuda, K.S., Paterson, S., Headey, S.J., Stacker, S.A., Hogan, B.M., Achen, M.G. (2019) Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis. Cell Reports. 28:2023-2036.e4

Grimm, L., Nakajima, H., Chaudhury, S., Bower, N.I., Okuda, K.S., Cox, A.G., Harvey, N.L., Koltowska, K., Mochizuki, N., Hogan, B.M. (2019) Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. eLIFE. 8:

Baek, S., Oh, T.G., Secker, G., Sutton, D.L., Okuda, K.S., Paterson, S., Bower, N.I., Toubia, J., Koltowska, K., Capon, S.J., Baillie, G.J., Simons, C., Muscat, G.E.O., Lagendijk, A.K., Smith, K.A., Harvey, N.L., Hogan, B.M. (2019) The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Developmental Cell. 49:279-292.e5

Eng, T.C., Chen, W., Okuda, K.S., Misa, J.P., Padberg, Y., Crosier, K.E., Crosier, P.S., Hall, C.J., Schulte-Merker, S., Hogan, B.M., Astin, J.W. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports. 20(5):

Tan, P. J., Lau, B. F., Krishnasamy, G., Ng, M. F., Husin, L. S., Ruslan, N., Song, D. S.S., Velaithan, V., Okuda, K. S., and Patel, V. (2018) Zebrafish embryonic development-interfering macrolides from Streptomyces californicus impact growth and mitochondrial function in human colorectal cancer cells. Process Biochemistry. 74:164-174

Samat, N., Ng, M.F., Ruslan, N.F., Okuda, K.S., Tan, P.J., Patel, V. (2018) Interference Potential of Tannins and Chlorophylls in Zebrafish Phenotypic-Based Assays. Assay and drug development technologies. 16(7):408-419

Okuda, K.S., Baek, S., Hogan, B.M. (2018) Visualization and Tools for Analysis of Zebrafish Lymphatic Development. Methods in molecular biology (Clifton, N.J.). 1846:55-70

Velaithan, V., Okuda, K.S., Ng, M.F., Samat, N., Leong, S.W., Faudzi, S.M., Abas, F., Shaari, K., Cheong, S.C., Tan, P.J., Patel, V. (2017) Zebrafish phenotypic screen identifies novel notch antagonists. Investigational new drugs. 35(2):166-179

Velaithan, V., Okuda, K.S., Ng, M.F., Samat, N., Leong, S.W., Faudzi, S.M., Abas, F., Shaari, K., Cheong, S.C., Tan, P.J., Patel, V. (2017) Erratum to: Zebrafish phenotypic screen identifies novel Notch antagonists. Investigational new drugs.

Dalton, J.P., Uy, B., Okuda, K.S., Hall, C.J., Denny, W.A., Crosier, P.S., Swift, S., Wiles, S. (2017) Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model. The Journal of antimicrobial chemotherapy. 72(2):421-427

Okuda, K.S., Lee, H.M., Velaithan, V., Ng, M.F., Patel, V. (2016) Utilizing zebrafish to identify anti-(lymph)angiogenic compounds for cancer treatment: promise and future challenges. Microcirculation (New York, N.Y. : 1994). 23(6):389-405

Okuda, K.S., Tan, P.J., Patel, V. (2016) Sprouting Buds of Zebrafish Research in Malaysia: First Malaysia Zebrafish Disease Model Workshop. Zebrafish. 13(2):138-41

Okuda, K.S., Misa, J.P., Oehlers, S.H., Hall, C.J., Ellett, F., Alasmari, S., Lieschke, G.J., Crosier, K.E., Crosier, P.S., Astin, J.W. (2015) A zebrafish model of inflammatory lymphangiogenesis. Biology Open. 4(10):1270-80

Oehlers, S.H., Cronan, M.R., Scott, N.R., Thomas, M.I., Okuda, K.S., Walton, E.M., Beerman, R.W., Crosier, P.S., Tobin, D.M. (2015) Interception of host angiogenic signalling limits mycobacterial growth. Nature. 517(7536):612-5

Astin, J.W., Haggerty, M.J., Okuda, K.S., Le Guen, L., Misa, J.P., Tromp, A., Hogan, B.M., Crosier, K.E., Crosier, P.S. (2014) Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development (Cambridge, England). 141(13):2680-90

Oehlers, S.H., Flores, M.V., Hall, C.J., Okuda, K.S., Sison, J.O., Crosier, K.E., and Crosier, P.S. (2013) Chemically Induced Intestinal Damage Models in Zebrafish Larvae. Zebrafish. 10(2):184-93

Okuda, K.S., Astin, J.W., Misa, J.P., Flores, M.V., Crosier, K.E., and Crosier, P.S. (2012) lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development (Cambridge, England). 139(13):2381-2391

Oehlers, S.H., Flores, M.V., Okuda, K.S., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):288-298

NON-ZEBRAFISH PUBLICATIONS