ZFIN Person: Yuh, Chiou-Hwa (Cathy)

ZFIN ID: ZDB-PERS-131203-7

ZFIN ID: ZDB-PERS-131203-7

Yuh, Chiou-Hwa (Cathy)

Email:	chyuh@nhri.org.tw
URL:	https://mg.nhri.edu.tw/tw/investigators/dr-chiou-hwa-yuh/
Affiliation:	Yuh Lab
Address:	#35 Keyan Road, Zhunan Town, Miaoli County, Taiwan, R.O.C. R2-3033, Institute of Molecular and Genomic Medicine, National Health Research
Country:	Taiwan
Phone:	011-886-37-206166 extension 35337
Fax:	011-886-37-586459
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Brief Autobiography:
Dr. Yuh received her B.A. from Biology Division at Fu-Jen Catholic University, Taiwan in 1987, and received her Ph.D. from Institute of Microbiology and Immunology at National Yang-Ming Medical College, Taiwan in 1992 on investigating the action mechanisms of second enhancer and core promoter of the Hepatitis B virus. She joined the Biology Division in California Institutes of Technology as a postdoc in the fall of 1992, under the direction of Dr. Eric Davidson and studying the gene regulatory networks of sea urchin endoderm. Dr. Yuh DMGM at NHRI as an Associate Investigator on 2005, and started zebrafish and cancer research since then. Yuh’s lab has established the gene regulatory networks for zebrafish embryogenesis, functional dissecting the important subcircuits in the endoderm networks and systematically approach reveals the evolution of pathways deregulated in the hepatocellular carcinogenesis using HBx induced HCC mouse model and transgenic zebrafish.

Present Appointment
1. Associate Investigator (2005-date), Institute of Molecular and Genomic Medicine, National Health Research Institutes
2. Adjunct Associate Professor (2006/8/1-date), Institute of Bioinformatics and Structural Biology, National Tsing Hua University
3. Joint Associate Professor (2007/3/22-date), Department of the Biological Science & Technology, National Chiao Tung University

Career Highlight: (in the past 5 years)
1. Establish zebrafish liver cancer model using transgenesis and xenotransplantation technologies.
2. Start drug screening platform using zebrafish model for anti-angiogenesis and anti-cancer small molecules.
3. Establish endoderm gene regulatory networks in zebrafish development.

Academic Background (please indicate period):
1. B.S., Biology, Fu-Jen Catholic University, Taipei, Taiwan. , 1983~1987
2. Ph.D. Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, 1987~1992
3. Research Fellow, Senior Research Fellow, Research Associate, Director, Member of the Professional Staff 1992-2004, California Institute of Technology

Honor and Awards:
1. Gordon Ross Fellowship, California Institute of Technology, USA, August 1994
2. Procter and Gamble Fellowship, California Institute of Technology, USA, August 1993
3. Number 1 award Wang Ming-Ning Memorial Foundation, Taiwan, December 1991

Professional Affiliation / Membership: (list no more than 10)
1. Editorial Board of Global Journal of Biochemistry –Gene Regulatory Mechanisms since 2010
2. Editorial Board of International Scholarly Research Network- Molecular Biology since 2011

Publications Highlights:
1. Lu J.W., Liao C.Y., Yang, W.Y., Lin Y.M., Jin S.L.C., Wang, H.D., and Yuh, C.H.*, Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway, PLoS One (accepted).
2. Yeh D.W., Liu Y.L., Lo Y.C., Yuh C.H., Yu G.Y., Lo J.F., Luo Y.P., Xiang R., and Chuang T.H., TLR9 and TLR21 have different ligand recognition profiles and cooperatively mediate anti-microbial activity of CpG-ODN in zebrafish, Proc. Natl. Acad. Sci. USA. 2013 (accepted).
3. Huang J., Chen W.H., Tseng W.F., Lin G.H., Huang F., Schreiner A., Chen H.R., Voigt M., Yuh C.H., Wu J.L., and Huang S.S., The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish, CellBio December, 2013 (Vol.3, No.4).
4. Lu J.W., Yang W.Y., Lin Y.M., Chang P.H., Chen J.R., Tsai S.M., Wang, H.D., Wu J.L., Jin S.L.C., and Yuh, C.H.*, Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish, PLoSOne 2013 Oct 9;8(10):e76951
5. Lu J.W., Yang W.Y., Lin Y.M., Jin S.L.C. and Yuh, C.H.*, Hepatitis B virus X antigen and Aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish, Acta Histochemica 2013 Sep;115(7):728-39.
6. Liu H., Wang X., Wang H.D. Wu J., Ren J., Meng L., Wu Q., Dong H., Wu J., Kao T.Y., Ge Q., Wu Z.X., Yuh C.H., Shan G.. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nature Communications September 25, 2012. 3:1073.
7. Wang C.T., Chen Y.C., Wang Y.Y., Huang M.H., Yen T.L., Li H., Liang C.J., Sang T.K., Cho S.C., Yuh, C.H., Wang C. Y., Brummel T. J., and Wang H. D., Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila, Aging Cell 2012 Feb. 11(1), 93–103
8. Lu J.W., Yu H., Yang W.Y., Lin Y.I., Li C.C., Tsai T.F., Chang K.W., Shieh G. S., Tsai S.F., Wang H.D., and Yuh, C.H.*, Common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model, Carcinogenesis. 2012 Jan;33(1):209-219
9. Tseng W.F., Jang T.H., Huang C.B., and Yuh, C.H.*, An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish, Developmental Biology, 2011 Sep 15;357(2):541-57
10. Lu J.W., Yu H., Tu H.C., Hsiao Y.C., Yang W.Y., Wang H.D., and Yuh, C.H.*, Liver development and cancer formation in zebrafish, Birth Defects Research Part C-Embryo Today-Reviews, 2011 June;93(2):157-172
11. Chan T. M., Chao C. H., Wang H. D., Yu Y. J., and Yuh, C.H.* Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish. Developmental Biology, 2009 Feb 15; 326 (2):456-470
12. Chan T.M., Longabaugh W., Bolouri H., Chen H.L., Tseng W.F., Chao C.H., Jang T.H., Lin Y.I., Hung S.C., Wang H.D., and Yuh, C.H.*, Developmental gene regulatory networks in the zebrafish embryo. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2009 Apr, 1789(4):279-298
13. Davidson E.H., Rast J.P., Oliveri P., Ransick A., Calestani C., Yuh C.H., Minokawa T., Amore G., Hinman V., Arenas-Mena C., Otim O., Brown C.T., Livi C.B., Lee P.Y., Revilla R., Rust A.G., Pan Z., Schilstra M.J., Clarke P.J., Arnone M.I., Rowen L., Cameron R.A., McClay D.R., Hood L., Bolouri H.A., genomic regulatory network for development, Science, 295, 1669-1678, 2002 (SCI, IF: 31.201)
14. Yuh, C.H., Bolouri, H. and Davidson, E.H., Cis-Regulatory Logic in the Endo16 Gene: Switching from a Specification to a Differentiation Mode of Control. Development, 128(5):617-29, 2001(SCI, IF: 6.596)
15. Yuh, C.H., Bolouri, H. and Davidson, E. H., Genomic Cis-regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene. Science, 279, 1896-1902, 1998 (SCI, IF: 31.201)

PATENT:
1. EARLY BIOMARKER FOR HEPATOCELLULAR CARCINOMA, United States Patent Application number 13/220,055, 9/9/2013 (granted), Horng-Dar Wang, Chiou-Hwa Yuh, Yung-Chun Hsiao, Yu-Ting Chou
2. RPIA PROMOTE CANCER CELL APOPTOSIS OR INHIBIT MIGRATION, Taiwan Patent Application number 100112343, 11/5/2013 (granted), Horng-Dar Wang, Chiou-Hwa Yuh, Yu-Ting Chou, Shih-Ci Chou
3. EARLY BIOMARKER FOR HEPATOCELLULAR CARCINOMA, Taiwan Patent (pending), Horng-Dar Wang, Chiou-Hwa Yuh, Yung-Chun Hsiao, Yu-Ting Chou
4. RPIA PROMOTE CANCER CELL APOPTOSIS OR INHIBIT MIGRATION, United States Patent (pending), Horng-Dar Wang, Chiou-Hwa Yuh, Yu-Ting Chou, Shih-Ci Chou
5. A METHOD FOR EARLY DIAGNOSIS OF LIVER CANCER, United States Patent (pending), Horng-Dar Wang, Chiou-Hwa Yuh, Hsiao-Chen Tu, Yu-Ting Chou

PUBLICATIONS

Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):

Lin, H.D., Tseng, Y.K., Yuh, C.H., Chen, S.C. (2021) Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. Journal of hazardous materials. 423:126954

Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8

Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252

Tseng, L.L., Cheng, H.H., Yeh, T.S., Huang, S.C., Syu, Y.Y., Chuu, C.P., Yuh, C.H., Kung, H.J., Wang, W.C. (2020) Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24859-24866

Wu, S.Y., Yang, W.Y., Cheng, C.C., Hsiao, M.C., Tsai, S.L., Lin, H.K., Lin, K.H., Yuh, C.H. (2020) Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model. Cancers. 12(6):

Cheng, C.C., Yang, W.Y., Hsiao, M.C., Lin, K.H., Lee, H.W., Yuh, C.H. (2020) Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis. Biomolecules. 10(6):

Wu, S.Y., Chou, H.Y., Tsai, H.C., Anbazhagan, R., Yuh, C.H., Yang, J.M., Chang, Y.H. (2020) Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model. RSC Advances. 10:20682-20690

Sie, Z.L., Li, R.Y., Sampurna, B.P., Hsu, P.J., Liu, S.C., Wang, H.D., Huang, C.L., Yuh, C.H. (2020) WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 12(3):

Addisu, K.D., Hsu, W.H., Hailemeskel, B.Z., Andrgie, A.T., Chou, H.Y., Yuh, C.H., Lai, J.Y., Tsai, H.C. (2019) Mixed Lanthanide Oxide Nanoparticles Coated with Alginate-Polydopamine as Multifunctional Nanovehicles for Dual Modality: Targeted Imaging and Chemotherapy. ACS biomaterials science & engineering. 5:5453-5469

Su, Z.L., Su, C.W., Huang, Y.L., Yang, W.Y., Sampurna, B.P., Ouchi, T., Lee, K.L., Wu, C.S., Wang, H.D., Yuh, C.H. (2019) A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers. 11(7)

Lin, H.S., Huang, Y.L., Wang, Y.S., Hsiao, E., Hsu, T.A., Shiao, H.Y., Jiaang, W.T., Sampurna, B.P., Lin, K.H., Wu, M.S., Lai, G.M., Yuh, C.H. (2019) Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform. Cancers. 11(6)

Chou, Y.T., Chen, L.Y., Tsai, S.L., Tu, H.C., Lu, J.W., Ciou, S.C., Wang, H.D., Yuh, C.H. (2018) Ribose-5-Phosphate Isomerase A Overexpression Promotes Liver Cancer Development in Transgenic Zebrafish via Activation of ERK and β-catenin Pathways. Carcinogenesis. 40(3):461-473

Chou, Y.T., Jiang, J.K., Yang, M.H., Lu, J.W., Lin, H.K., Wang, H.D., Yuh, C.H. (2018) Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. PLoS Biology. 16:e2003714

Wu, S.Y., Chou, H.Y., Yuh, C.H., Mekuria, S.L., Kao, Y.C., Tsai, H.C. (2017) Radiation-Sensitive Dendrimer-Based Drug Delivery System. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 5:1700339

Hsu, D.S., Hwang, W.L., Yuh, C.H., Chu, C.H., Ho, Y.H., Chen, P.B., Lin, H.S., Lin, H.K., Wu, S.P., Lin, C.Y., Hsu, W.H., Lan, H.Y., Wang, H.J., Tai, S.K., Hung, M.C., Yang, M.H. (2017) Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 23(15):4388-4401

Yang, C.H., Yeh, Y.J., Wang, J.Y., Liu, Y.W., Chen, Y.L., Cheng, H.W., Cheng, C.M., Chuang, Y.J., Yuh, C.H., Chen, Y.R. (2017) NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Scientific Reports. 7:5241

Huang, Y.C., Lin, S.J., Shih, H.Y., Chou, C.H., Chu, H.H., Chiu, C.C., Yuh, C.H., Yeh, T.H., Cheng, Y.C. (2017) Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation. Oncotarget. 8:63110-63120

Tu, H.C., Hsiao, Y.C., Yang, W.Y., Tsai, S.L., Lin, H.K., Liao, C.Y., Lu, J.W., Chou, Y.T., Wang, H.D., Yuh, C.H. (2017) Up-regulation of golgi α-mannosidase IA and down-regulation of golgi α-mannosidase IC activates unfolded protein response during hepatocarcinogenesis. Hepatology communications. 1:230-247

You, M.S., Jiang, Y.J., Yuh, C.H., Wang, C.M., Tang, C.H., Chuang, Y.J., Lin, B.H., Wu, J.L., Hwang, S.L. (2016) A Sketch of the Taiwan Zebrafish Core Facility. Zebrafish. 13 Suppl 1:S24-9

Lu, J.W., Liao, C.Y., Yang, W.Y., Lin, Y.M., Jin, S.L., Wang, H.D., and Yuh, C.H. (2014) Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. PLoS One. 9(1):e85318

Yeh, D.W., Liu, Y.L., Lo, Y.C., Yuh, C.H., Yu, G.Y., Lo, J.F., Luo, Y., Xiang, R., and Chuang, T.H. (2013) Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 110(51):20711-20716

Lu, J.W., Yang, W.Y., Tsai, S.M., Lin, Y.M., Chang, P.H., Chen, J.R., Wang, H.D., Wu, J.L., Jin, S.L., and Yuh, C.H. (2013) Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish. PLoS One. 8(10):e76951

Chen, W., Tseng, X., Lin, G., Schreiner, A., Chen, H., Voigt, M.M., Yuh, C., Wu, J., Huang, S.S., and Huang, J. (2013) The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish. CellBio. 2(4):228-247

Lu, J.W., Yang, W.Y., Lin, Y.M., Jin, S.L., and Yuh, C.H. (2013) Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 115(7):728-39

Tseng, W.F., Jang, T.H., Huang, C.B., and Yuh, C.H. (2011) An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish. Developmental Biology. 357(2):541-57

Lu, J.W., Hsia, Y., Tu, H.C., Hsiao, Y.C., Yang, W.Y., Wang, H.D., and Yuh, C.H.. (2011) Liver development and cancer formation in zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(2):157-172

Chao, C.H., Wang, H.D., and Yuh, C.H. (2010) Complexity of cis-regulatory organization of six3a during forebrain and eye development in zebrafish. BMC Developmental Biology. 10:35

Chen, H.L., Yuh, C.H., and Wu, K.K. (2010) Nestin Is Essential for Zebrafish Brain and Eye Development through Control of Progenitor Cell Apoptosis. PLoS One. 5(2):e9318

Chan, T.M., Longabaugh, W., Bolouri, H., Chen, H.L., Tseng, W.F., Chao, C.H., Jang, T.H., Lin, Y.I., Hung, S.C., Wang, H.D., and Yuh, C.H. (2009) Developmental gene regulatory networks in the zebrafish embryo. Biochimica et biophysica acta. Gene regulatory mechanisms. 1789(4):279-298

Chan, T.M., Chao, C.H., Wang, H.D., Yu, Y.J., and Yuh, C.H. (2009) Functional analysis of the evolutionarily conserved Cis-regulatory elements on the Sox17 gene in zebrafish. Developmental Biology. 326(2):456-470

NON-ZEBRAFISH PUBLICATIONS
BOOKS:
1. Yuh, C. H. and Ting, L. P. Cooperation of Two Elements within the Second Enhancer of the Human Hepatitis B viral Genome, Viral Hepatitis and Liver Disease, 176-182, Harper Graphics, Inc. Waldorf, MD. 1990
2. Yuh, C. H., Bolouri, H., Bower, J. M., and Davidson, E. H. A Logical Model of Cis-Regulatory Control in a Eukaryotic System, Computational Modeling of Genetic and Biochemical Networks (Bower and Bolouri, editors) The MIT press, 73-100, 2000
3. Coffman, J. A. and Yuh, C. H. Identification of Sequence-specific DNA Binding Proteins, Academic Press/Elsevier Science, Methods in Cell Biology Series, 74: 653-675, 2004 Harper Graphics, Inc. Waldorf, MD. 1990.

JOURNALS:
1. Lu J.W., Liao C.Y., Yang, W.Y., Lin Y.M., Jin S.L.C., Wang, H.D., and Yuh, C.H.*, Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway, PLoS One (accepted).
2. Yeh D.W., Liu Y.L., Lo Y.C., Yuh C.H., Yu G.Y., Lo J.F., Luo Y.P., Xiang R., and Chuang T.H., TLR9 and TLR21 have different ligand recognition profiles and cooperatively mediate anti-microbial activity of CpG-ODN in zebrafish, Proc. Natl. Acad. Sci. USA. 2013 (accepted).
3. Huang J., Chen W.H., Tseng W.F., Lin G.H., Huang F., Schreiner A., Chen H.R., Voigt M., Yuh C.H., Wu J.L., and Huang S.S., The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish, CellBio December, 2013 (Vol.3, No.4).
4. Lu J.W., Yang W.Y., Lin Y.M., Chang P.H., Chen J.R., Tsai S.M., Wang, H.D., Wu J.L., Jin S.L.C., and Yuh, C.H.*, Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish, PLoSOne 2013 Oct 9;8(10):e76951 (IF=3.730;R/C= 7/56; MULTIDISCIPLINARY SCIENCES)
5. Lu J.W., Yang W.Y., Lin Y.M., Jin S.L.C. and Yuh, C.H.*, Hepatitis B virus X antigen and Aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish, Acta Histochemica 2013 Sep;115(7):728-39. (IF=1.608; R/C=153/185 ; CELL BIOLOGY)
6. Liu H., Wang X., Wang H.D. Wu J., Ren J., Meng L., Wu Q., Dong H., Wu J., Kao T.Y., Ge Q., Wu Z.X., Yuh C.H., Shan G.. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nature Communications September 25, 2012. 3:1073. (IF : 10.015; R/C= 3/56 ; MULTIDISCIPLINARY SCIENCES)
7. Wang C.T., Chen Y.C., Wang Y.Y., Huang M.H., Yen T.L., Li H., Liang C.J., Sang T.K., Cho S.C., Yuh, C.H., Wang C. Y., Brummel T. J., and Wang H. D., Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila, Aging Cell 2012 Feb. 11(1), 93–103 (IF : 5.705, R/C= 40/185 ; CELL BIOLOGY)
8. Lu J.W., Yu H., Yang W.Y., Lin Y.I., Li C.C., Tsai T.F., Chang K.W., Shieh G. S., Tsai S.F., Wang H.D., and Yuh, C.H.*, Common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model, Carcinogenesis 2012 Jan;33(1):209-219 ( IF: 5.635; R/C= 28/197; ONCOLOGY)
9. Tseng W.F., Jang T.H., Huang C.B., and Yuh, C.H.*, An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish, Developmental Biology 2011 Sep 15;357(2):541-57 (IF: 3.868; R/C= 11/41; DEVELOPMENTAL BIOLOGY)
10. Lu J.W., Yu H., Tu H.C., Hsiao Y.C., Yang W.Y., Wang H.D., and Yuh, C.H.*, Liver development and cancer formation in zebrafish, Birth Defects Research Part C-Embryo Today 2011 June;93(2):157-172 (IF: 4.442；R/C= 8/41，DEVELOPMENTAL BIOLOGY)
11. Ko C.Y., Tsai M.Y., Tseng W.F., Cheng C.H., Huang C.R., Wu J.S., Chung H.Y., Hsieh C.S., Sun C.K., Hwang S.P., Yuh, C.H., Huang C.J., Pai T.W., Tzou W.S., and Hu C.H., Integration of CNS survival and differentiation by HIF2α, Cell Death and Differentiation 2011 Nov;18(11):1757-70 (IF: 8.849)
12. Chao C.H., Tseng W.F., Chan T.M., Chen H.L., Huang C.B., Jang T.H., Hsu H.Y., Wang H.D., and Yuh, C.H.*, Mesendoderm gene regulatory networks in zebrafish, Global Journal of Biochemistry 2011, 2(4): 215-249
13. Chao C.H., Wang H.D., and Yuh, C.H.*, Complexity of cis-regulatory organization of six3a during forebrain and eye development in zebrafish. BMC Developmental Biology 2010 Mar 26;10(1):35 (IF: 2.728; R/C= 22/41; DEVELOPMENTAL BIOLOGY)
14. Chen H.L., Yuh, C.H., and Wu K.K. Nestin Is Essential for Zebrafish Brain and Eye Development through Control of Progenitor Cell Apoptosis. PLoSOne 2010 Feb, 19;5(2):e9318 (IF=3.730;R/C= 7/56; MULTIDISCIPLINARY SCIENCES)
15. Liu Y.L., Lu W.C., Brummel T.J., Yuh, C.H., Lin P.T., Kao T.Y., Li F.Y., Liao P.C., Benzer S., and Wang H.D. Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell 2009, Aug; 8 (4):370-379 (IF : 5.705, R/C= 40/185 ; CELL BIOLOGY)
16. Chan T. M., Chao C. H., Wang H. D., Yu Y. J., and Yuh, C.H.* Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish. Developmental Biology 2009 Feb 15; 326 (2):456-470 (IF: 3.868; R/C= 11/41; DEVELOPMENTAL BIOLOGY)
17. Chan T.M., Longabaugh W., Bolouri H., Chen H.L., Tseng W.F., Chao C.H., Jang T.H., Lin Y.I., Hung S.C., Wang H.D., and Yuh, C.H.*, Developmental gene regulatory networks in the zebrafish embryo. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 2009 Apr, 1789(4):279-298 (IF: 5.456; R/C= 47/290; BIOCHEMISTRY & MOLECULAR BIOLOGY)
18. Liao, P.C., Lin, H.Y., Yuh, C.H., Yu, L.K., and Wang, H.D., The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration and apoptosis in Drosophila. Biochemical and Biophysical Research Communications 2008 Nov 28;376(4):637-641 (IF : 2.484)
19. Liu, P. K., Yuh, C.H., and Wang, F. S., Inference of Genetic Regulatory Networks Using S-system and Hybrid Differential Evolution. Proceedings of 2008 IEEE Congress on Evolutionary Computation 1736-1743 (EI)
20. Yuh, C.H., Dorman E.R. and Davidson, E.H., Brn1/2/4, the predicted midgut regulator of the Endo16 gene of the sea urchin embryo. Developmental Biology 2005 May 15; 281(2):286-298
21. Yuh, C.H., Dorman E.R., Howard M.L. and Davidson, E.H., An otx cis-regulatory module: a key node in the sea urchin endomesoderm gene regulatory network. Developmental Biology 2004 May 15;269(2):536-51
22. Davidson E.H., Rast J.P., Oliveri P., Ransick A., Calestani C., Yuh C.H., Minokawa T., Amore G., Hinman V., Arenas-Mena C., Otim O., Brown C.T., Livi C.B., Lee P.Y., Revilla R., Schilstra M.J., Clarke P.J., Rust A.G., Pan Z., Arnone M.I., Rowen L., Cameron R.A., McClay D.R., Hood L., Bolouri H.A., provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo, Developmental Biology 246(1):162-190, 2002
23. Yuh, C.H., Brown T.B., Livi C., Clarke, P.J.C. and Davidson E.H. Patchy Interspecific Sequence Similarities Efficiently Identify Active Cis-Regulatory Elements in the Sea Urchin, Developmental Biology 246(1):148-161, 2002
24. Davidson E.H., Rast J.P., Oliveri P., Ransick A., Calestani C., Yuh C.H., Minokawa T., Amore G., Hinman V., Arenas-Mena C., Otim O., Brown C.T., Livi C.B., Lee P.Y., Revilla R., Rust A.G., Pan Z., Schilstra M.J., Clarke P.J., Arnone M.I., Rowen L., Cameron R.A., McClay D.R., Hood L., Bolouri H.A., genomic regulatory network for development, Science 295, 1669-1678, 2002
25. Yuh, C.H., Li, X., Davidson, E.H. and Klein, W.H., Correct Expression of spec2a in the Sea Urchin Embryo Requires Both Otx and Other Cis-Regulatory Elements, Developmental Biology 232(2):424-38, 2001
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37. Chang, H. K., Wang, B. Y., Yuh, C.H., Wei, C. L., and Ting, L. P., A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of the Human Hepatitis B virus. Mol. Cell Biol. 9: 5189-5197, 1989

MANUSCRIPTS UNDER REVISION:
1. Lai J.G., Chen W.C., Kou F.J., Lu J.W., Huang C.L. and Yuh, C.H.*, Zebrafish with no lysine kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling, PLoS One (under revision).

MANUSCRIPTS IN PREPARATION:
1. Tsai S.M., Lu J.W., and Yuh, C.H.*,, Activation of Unfolding Protein response during hepatocarcinogenesis in transgenic zebrafish (in preparation)
2. Tu H.C., Hsiao Y.C., Liao C.Y., Lu J.W., Chou Y.T., Wang H.D., Yuh, C.H.*, Alpha-1,2 mannosidase, MAN1A1 overexpression promotes hepatocellular carcinoma; MAN1C1 downregulation predicts early stage of HCC (in preparation)