ZFIN ID: ZDB-PERS-130612-1
Sieger, Dirk
Email: dirk.sieger@ed.ac.uk
URL: http://www.cnr.ed.ac.uk/Research/sieger.html
Affiliation: Sieger Lab
Address: Centre for Neuroregeneration The University of Edinburgh The Chancellor's Building 49 Little France Crescent Edinburgh EH16 4SB
Country: UK
Phone: +44 (0)1312426161


Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Zagury, J.F., Sieger, D. (2022) Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Glia. 70(6):1027-1051
Benson, S., de Moliner, F., Fernandez, A., Kuru, E., Asiimwe, N.L., Lee, J.S., Hamilton, L., Sieger, D., Bravo, I.R., Elliot, A.M., Feng, Y., Vendrell, M. (2021) Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Nature communications. 12:2369
Astell, K.R., Sieger, D. (2019) Zebrafish In Vivo Models of Cancer and Metastasis. Cold Spring Harbor Perspectives in Medicine. 10(8)
Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Kuil, L.E., van Ham, T.J., Zagury, J.F., Sieger, D. (2019) Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Glia. 68(2):298-315
Chia, K., Keatinge, M., Mazzolini, J., Sieger, D. (2019) Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation. eLIFE. 8:
Mazzolini, J., Chia, K., Sieger, D. (2018) Isolation and RNA Extraction of Neurons, Macrophages and Microglia from Larval Zebrafish Brains. Journal of visualized experiments : JoVE. (134)
Chia, K., Mazzolini, J., Mione, M., Sieger, D. (2018) Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. eLIFE. 7
Pérez-López, A.M., Rubio-Ruiz, B., Sebastián, V., Hamilton, L., Adam, C., Bray, T.L., Irusta, S., Brennan, P.M., Lloyd-Jones, G., Sieger, D., Santamaría, J., Unciti-Broceta, A. (2017) Gold-Triggered Uncaging Chemistry in Living Systems. Angewandte Chemie (International ed. in English). 56(41):12548-12552
Astell, K.R., Sieger, D. (2017) Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain. Methods in cell biology. 138:593-626
Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
Hamilton, L., Astell, K.R., Velikova, G., Sieger, D. (2016) A Zebrafish Live Imaging Model Reveals Differential Responses of Microglia Toward Glioblastoma Cells In Vivo. Zebrafish. 13(6):523-534
Ohnmacht, J., Yang, Y.J., Maurer, G.W., Barreiro-Iglesias, A., Tsarouchas, T.M., Wehner, D., Sieger, D., Becker, C.G., Becker, T. (2016) Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish. Development (Cambridge, England). 143(9):1464-74
Chuang, H.N., van Rossum, D., Sieger, D., Siam, L., Klemm, F., Bleckmann, A., Bayerlová, M., Farhat, K., Scheffel, J., Schulz, M., Dehghani, F., Stadelmann, C., Hanisch, U.K., Binder, C., and Pukrop, T. (2013) Carcinoma cells misuse the host tissue damage response to invade the brain. Glia. 61(8):1331-46
Sieger, D., and Peri, F. (2013) Animal models for studying microglia: the first, the popular, and the new.. Glia. 61(1):3-9
Boecke, A., Sieger, D., Neacsu, C.D., Kashkar, H., and Krönke, M. (2012) Factor Associated with Neutral Sphingomyelinase Activity Mediates Navigational Capacity of Leukocytes Responding to Wounds and Infection: Live Imaging Studies in Zebrafish Larvae. Journal of immunology (Baltimore, Md. : 1950). 189(4):1559-1566
Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S., and Peri, F. (2012) Long-Range Ca(2+) Waves Transmit Brain-Damage Signals to Microglia. Developmental Cell. 22(6):1138-1148
Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G., and Leptin, M. (2010) In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 185(11):6774-6782
Sieger, D., Stein, C., Neifer, D., van der Sar, A.M., and Leptin, M. (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Disease models & mechanisms. 2(11-12):571-581
Shankaran, S.S., Sieger, D., Schroter, C., Czepe, C., Pauly, M.C., Laplante, M.A., Becker, T.S., Oates, A.C., and Gajewski, M. (2007) Completing the set of h/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock. Developmental Biology. 304(2):615-632
Gajewski, M., Elmasri, H., Girschick, M., Sieger, D., and Winkler, C. (2006) Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Development genes and evolution. 216(6):315-332
Sieger, D., Ackermann, B., Winkler, C., Tautz, D., and Gajewski, M. (2006) her1 and her13.2 are jointly required for somitic border specification along the entire axis of the fish embryo. Developmental Biology. 293(1):242-251
Sieger, D. (2005) Su(H) mediated Notch signalling and the role of different her genes during zebrafish somitogenesis. Ph.D. Thesis.
Sieger, D., Tautz, D., and Gajewski, M. (2004) her11 is involved in the somitogenesis clock in zebrafish. Development genes and evolution. 214(8):393-406
Sieger, D., Tautz, D., and Gajewski, M. (2003) The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Mechanisms of Development. 120(9):1083-1094
Gajewski, M., Sieger, D., Alt, B., Leve, C., Hans, S., Wolff, C., Rohr, K.B., and Tautz, D. (2003) Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development (Cambridge, England). 130(18):4269-4278