ZFIN Person: Hill, Caroline

ZFIN ID: ZDB-PERS-110602-1

ZFIN ID: ZDB-PERS-110602-1

Hill, Caroline

Email:	caroline.hill@crick.ac.uk
URL:
Affiliation:	Hill Lab
Address:	The Francis Crick Institute 1 Midland Road London NW1 1AT UK
Country:	United Kingdom
Phone:	+44 20 3796 1251
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Biography

Caroline Hill carried out her Ph.D studies in the laboratory of Jean Thomas at the University of Cambridge UK, working on chromatin structure. After receiving her Ph.D in 1989 she carried out postdoctoral studies in the same lab before moving in 1991 to Imperial Cancer Research Fund, London, UK to work on the regulation of c-fos gene expression by growth factors with Richard Treisman. In 1995 she set up her own lab at the Ludwig Institute for Cancer Research, London, UK working on signalling by TGF-beta superfamily members in early vertebrate development and cancer. She moved her laboratory to the Cancer Research UK London Research Institute in 1998, and got tenure in 2002. She moved to the newly established Francis Crick Institute in 2016 and is a Principal Research Scientist and Assistant Research Director.

PUBLICATIONS

Wilcockson, S.G., Guglielmi, L., Araguas Rodriguez, P., Amoyel, M., Hill, C.S. (2023) An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development. Developmental Cell. 58(23):2802-2818.e5

Economou, A.D., Guglielmi, L., East, P., Hill, C.S. (2022) Nodal signaling establishes a competency window for stochastic cell fate switching. Developmental Cell. 57:26042622.e52604-2622.e5

Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374

van Boxtel, A.L., Economou, A.D., Heliot, C., Hill, C.S. (2017) Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Developmental Cell. 44(2):179-191.e5

van Boxtel, A.L., Chesebro, J.E., Heliot, C., Ramel, M.C., Stone, R.K., Hill, C.S. (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Developmental Cell. 35:175-185

Ramel, M.C., and Hill, C.S. (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Developmental Biology. 378(2):170-82

Sanvitale, C.E., Kerr, G., Chaikuad, A., Ramel, M.C., Mohedas, A.H., Reichert, S., Wang, Y., Triffitt, J.T., Cuny, G.D., Yu, P.B., Hill, C.S., and Bullock, A.N. (2013) A New Class of Small Molecule Inhibitor of BMP Signaling. PLoS One. 8(4):e62721

Wu, M.Y., Ramel, M.C., Howell, M., and Hill, C.S. (2011) SNW1 Is a Critical Regulator of Spatial BMP Activity, Neural Plate Border Formation, and Neural Crest Specification in Vertebrate Embryos. PLoS Biology. 9(2):e1000593

Batut, J., Howell, M., and Hill, C.S. (2007) Kinesin-mediated transport of smad2 is required for signaling in response to tgf-Beta ligands. Developmental Cell. 12(2):261-274

Dorey, K., and Hill, C.S. (2006) A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos. Developmental Biology. 292(2):303-316

Randall, R.A., Germain, S., Inman, G.J., Bates, P.A., and Hill, C.S. (2002) Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. The EMBO journal. 21(1-2):145-156

NON-ZEBRAFISH PUBLICATIONS
Examples of recent non-zebrafish publications

Miller, D. S. J., Bloxham, R. D., Jiang, M., Gori, I., Saunders, R. E., Das, D., Chakravarty, P., Howell, M., and Hill, C. S. (2018) The dynamics of TGF- signaling are dictated by receptor trafficking via the ESCRT machinery. Cell Rep 25, 1841-1855.e1845.

Coda, D. M., Gaarenstroom, T., East, P., Patel, H., Miller, D. S. J., Lobley, A., Matthews, N., Stewart, A., and Hill, C. S. (2017) Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling. Elife 6, e22474.

Ramachandran, A., Vizán, P., Das, D., Chakravarty, P., Vogt, J., Rogers, K. W., Müller, P., Hinck, A. P., Sapkota, G. P., and Hill, C. S. (2018) TGF- uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition. Elife 7, e31756

Ramachandran, A., Mehić, M., Wasim, L., Malinova, D., Gori, I., Blaszczyk, B. K., Carvalho, D. M., Shore, E. M., Jones, C., Hyvönen, M., Tolar, P., and Hill, C. S. (2021) Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. EMBO J 40, e106317.

Gori, I., George, R., Purkiss, A. G., Strohbuecker, S., Randall, R. A., Ogrodowicz, R., Carmignac, V., Faivre, L., Joshi, D., Kjær, S., and Hill, C. S. (2021) Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization. Elife 10, e63545.