ZFIN Person: Bessa, Jose

ZFIN ID: ZDB-PERS-110304-1

ZFIN ID: ZDB-PERS-110304-1

Bessa, Jose

Email:	jose.bessa@ibmc.up.pt
URL:	http://www.i3s.up.pt/personal-info.php?id=482&idg=112
Affiliation:	Vertebrate Development and Regeneration Lab
Address:
Country:	Portugal
Phone:
Fax:
ORCID ID:	0000-0002-8591-7138

BIOGRAPHY AND RESEARCH INTERESTS

José Bessa completed his PhD degree in Developmental Biology at ICBAS (University of Porto; 2008), acquiring advanced knowledge in the development of Drosophila and Zebrafish visual systems. As a postdoc, Jose Bessa has joined the laboratory of Dr Gomez-Skarmeta, an expert in zebrafish Functional Genomics. Currently, José Bessa leads the Vertebrate Development and Regeneration group at i3S - Instituto de Investigação e Inovação em Saúde, Porto. The Vertebrate Development and Regeneration group studies the mechanisms of cis-transcriptional regulation of genes and how mutations on non-coding cis-transcriptional regulatory sequences might impact in the development of some human diseases, in particular diabetes and pancreatic cancer. To achieve this, the VDR lab uses genomic strategies to identify non-coding cis-transcriptional regulatory sequences and perform genetic functional assays in zebrafish to evaluate the function of these sequences.

PUBLICATIONS

Matinha-Cardoso, J., Coutinho, F., Lima, S., Eufrásio, A., Carvalho, A.P., Oliva-Teles, A., Bessa, J., Tamagnini, P., Serra, C.R., Oliveira, P. (2022) Novel protein carrier system based on cyanobacterial nano-sized extracellular vesicles for application in fish. Microbial biotechnology. 15(8):2191-2207

Bordeira-Carriço, R., Teixeira, J., Duque, M., Galhardo, M., Ribeiro, D., Acemel, R.D., Firbas, P.N., Tena, J.J., Eufrásio, A., Marques, J., Ferreira, F.J., Freitas, T., Carneiro, F., Goméz-Skarmeta, J.L., Bessa, J. (2022) Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nature communications. 13:1945

Ferreira, F.J., Carvalho, L., Logarinho, E., Bessa, J. (2021) foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis. Cells. 10(5)

Eufrásio, A., Perrod, C., Ferreira, F.J., Duque, M., Galhardo, M., Bessa, J. (2020) In vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes Associated SNPs. Diabetes. 69(12):2794-2805

Amorim, J.P., Gali-Macedo, A., Marcelino, H., Bordeira-Carriço, R., Naranjo, S., Rivero-Gil, S., Teixeira, J., Galhardo, M., Marques, J., Bessa, J. (2020) A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates. Cell Reports. 32:107862

Seixas, A.I., Loureiro, J.R., Costa, C., Ordóñez-Ugalde, A., Marcelino, H., Oliveira, C.L., Loureiro, J.L., Dhingra, A., Brandão, E., Cruz, V.T., Timóteo, A., Quintáns, B., Rouleau, G.A., Rizzu, P., Carracedo, Á., Bessa, J., Heutink, P., Sequeiros, J., Sobrido, M.J., Coutinho, P., Silveira, I. (2017) A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. American journal of human genetics. 101:87-103

Fernández-Miñán, A., Bessa, J., Tena, J.J., Gómez-Skarmeta, J.L. (2016) Assay for transposase-accessible chromatin and circularized chromosome conformation capture, two methods to explore the regulatory landscapes of genes in zebrafish. Methods in cell biology. 135:413-30

Cebola, I., Rodríguez-Seguí, S.A., Cho, C.H., Bessa, J., Rovira, M., Luengo, M., Chhatriwala, M., Berry, A., Ponsa-Cobas, J., Maestro, M.A., Jennings, R.E., Pasquali, L., Morán, I., Castro, N., Hanley, N.A., Gomez-Skarmeta, J.L., Vallier, L., Ferrer, J. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nature cell biology. 17:615-26

Ariza-Cosano, A., Bensimon-Brito, A., Gómez-Skarmeta, J.L., Bessa, J. (2015) sox21a directs lateral line patterning by modulating FGF signaling. Developmental Neurobiology. 75(1):80-92

Spieler, D., Kaffe, M., Knauf, F., Bessa, J., Tena, J.J., Giesert, F., Schormair, B., Tilch, E., Lee, H., Horsch, M., Czamara, D., Karbalai, N., von Toerne, C., Waldenberger, M., Gieger, C., Lichtner, P., Claussnitzer, M., Naumann, R., Müller-Myhsok, B., Torres, M., Garrett, L., Rozman, J., Klingenspor, M., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., Beckers, J., Holter, S.M., Meitinger, T., Hauck, S.M., Laumen, H., Wurst, W., Casares, F., Gómez-Skarmeta, J.L., Winkelmann, J. (2014) Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome research. 24:592-603

Bessa, J., Luengo, M., Rivero-Gil, S., Ariza-Cosano, A., Maia, A.H., Ruiz-Ruano, F.J., Caballero, P., Naranjo, S., Carvajal, J.J., and Gómez-Skarmeta, J.L. (2014) A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome research. 24(3):487-95

Regadas, I., Matos, M.R., Monteiro, F.A., Gomez-Skarmeta, J.L., Lima, D., Bessa, J., Casares, F., and Reguenga, C. (2013) Several Cis-regulatory Elements Control mRNA Stability, Translation Efficiency, and Expression Pattern of Prrxl1 (Paired Related Homeobox Protein-like 1). The Journal of biological chemistry. 288(51):36285-301

Ariza-Cosano, A., Visel, A., Pennacchio, L.A., Fraser, H.B., Gómez-Skarmeta, J.L., Irimia, M., and Bessa, J. (2012) Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics. 13(1):713

Royo, J.L., Bessa, J., Hidalgo, C., Fernández-Miñán, A., Tena, J.J., Roncero, Y., Gómez-Skarmeta, J.L., and Casares, F. (2012) Identification and Analysis of Conserved cis-Regulatory Regions of the MEIS1 Gene. PLoS One. 7(3):e33617

Bessa, J., Tena, J.J., de la Calle-Mustienes, E., Fernández-Miñán, A., Naranjo, S., Fernández, A., Montoliu, L., Akalin, A., Lenhard, B., Casares, F., and Gómez-Skarmeta, J.L. (2009) Zebrafish enhancer detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(9):2409-2417

Bessa, J., Tavares, M.J., Santos, J., Kikuta, H., Laplante, M., Becker, T.S., Gómez-Skarmeta, J.L., and Casares, F. (2008) meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Development (Cambridge, England). 135(5):799-803

NON-ZEBRAFISH PUBLICATIONS