ZFIN ID: ZDB-PERS-101011-1
Xiao, Wuhan
Email: w-xiao@ihb.ac.cn
URL:
Affiliation: Xiao Lab
Address: Institute of Hydrobiology Chinese Academy of Sciences Wuhan, Hubei, 430072 China
Country: China
Phone: 86-27-68780087
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Research Interests:

* Genes involved in cancer initiation and progression
* Molecular mechanisms of genes related to cancer initiation and progression
* The roles of tumor suppressors and oncogenes in zebrafish embryogenesis

Our research is to understand the molecular mechanisms whereby cancer related genes are normally regulated and how abnormal gene regulation leads to cancer initiation and progression through cell culture system and zebrafish model. In addition, we also try to figure out the relationship between carcinogen/mutagen of aquatic environments and cancer development. These studies will help us to understand the mechanisms of carcinogenesis, and to ultimately develop novel approaches for diagnosing, preventing and treating cancer. In present, our research is funded by NSFC, 973 and other funding.


PUBLICATIONS
Cai, X., Wang, R., Zhu, J., Li, X., Liu, X., Ouyang, G., Wang, J., Li, Z., Zhu, C., Deng, H., Xiao, W. (2023) Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ. Cell Reports. 43:113606113606
Liao, Q., Deng, H., Wang, Z., Yu, G., Zhu, C., Jia, S., Liu, W., Bai, Y., Sun, X., Chen, X., Xiao, W., Liu, X. (2023) Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(12):105420
Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074
Ouyang, G., Liao, Q., Fan, S., Cai, X., Wang, J., Liu, X., Xiao, W. (2023) Zebrafish mavs Is Essential for Antiviral Innate Immunity. Journal of immunology (Baltimore, Md. : 1950). 210(9):1314-1323
Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822
Wang, Z., Chen, X., Fan, S., Zhu, C., Deng, H., Tang, J., Sun, X., Jia, S., Liao, Q., Xiao, W., Liu, X. (2022) Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity. The Journal of biological chemistry. 298(12):102633
Chen, X., Fan, S., Zhu, C., Liao, Q., Tang, J., Yu, G., Cai, X., Ouyang, G., Xiao, W., Liu, X. (2022) Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs. Journal of immunology (Baltimore, Md. : 1950). 209(6):1165-1172
Cai, X., Zhou, Z., Zhu, J., Liu, X., Ouyang, G., Wang, J., Li, Z., Li, X., Zha, H., Zhu, C., Rong, F., Tang, J., Liao, Q., Chen, X., Xiao, W. (2022) Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cell Reports. 39:110920
Zhai, G., Shu, T., Yu, G., Tang, H., Shi, C., Jia, J., Lou, Q., Dai, X., Jin, X., He, J., Xiao, W., Liu, X., Yin, Z. (2022) Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLIFE. 11:
Liao, Q., Ouyang, G., Zhu, J., Cai, X., Yu, G., Zhou, Z., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity. Journal of immunology (Baltimore, Md. : 1950). 207(12):3050-3059
Zhu, J., Li, X., Sun, X., Zhou, Z., Cai, X., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6. Journal of immunology (Baltimore, Md. : 1950). 207(10):2570-2580
Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., Ouyang, G., Xiao, W. (2021) Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 207(1):244-256
Yu, G., Liu, X., Zhang, D., Wang, J., Ouyang, G., Chen, Z., Xiao, W. (2020) Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development (Cambridge, England). 147(18):
Li, Z., Fan, S., Wang, J., Chen, X., Liao, Q., Liu, X., Ouyang, G., Cao, H., Xiao, W. (2020) Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 205(7):1897-1908
Yu, G., Li, X., Zhou, Z., Tang, J., Wang, J., Liu, X., Fan, S., Ouyang, G., Xiao, W. (2020) Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity. Journal of immunology (Baltimore, Md. : 1950). 205(4):1135-1146
Zhu, J., Liu, X., Cai, X., Ouyang, G., Zha, H., Zhou, Z., Liao, Q., Wang, J., Xiao, W. (2020) Zebrafish prmt3 negatively regulates antiviral responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(8):10212-10227
Ouyang, G., Liao, Q., Zhang, D., Rong, F., Cai, X., Fan, S., Zhu, J., Wang, J., Liu, X., Liu, X., Xiao, W. (2020) Zebrafish NF-κB/p65 Is Required for Antiviral Responses. Journal of immunology (Baltimore, Md. : 1950). 204(11):3019-3029
Zhu, J., Liu, X., Cai, X., Ouyang, G., Fan, S., Wang, J., Xiao, W. (2020) Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:988-1000
Zhu, J., Zhang, D., Liu, X., Yu, G., Cai, X., Xu, C., Rong, F., Ouyang, G., Wang, J., Xiao, W. (2019) Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. Development (Cambridge, England). 146(20):
Yu, G., Liu, X., Tang, J., Xu, C., Ouyang, G., Xiao, W. (2019) Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in immunology. 10:1432
Xiao, W., Cai, X., Zhang, D., Wang, J., Liu, X., Ouyang, G. (2018) Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish.. The Journal of biological chemistry. 293(40):15370-15380
Yu, G., Zhang, D., Liu, W., Wang, J., Liu, X., Zhou, C., Gui, J., Xiao, W. (2018) Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function. Oncotarget. 9:24320-24334
Wang, J., Zhang, D., Du, J., Zhou, C., Li, Z., Liu, X., Ouyang, G., Xiao, W. (2017) Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic acids research. 45(22):12700-12714
Zhang, D., Wang, J., Zhou, C., Xiao, W. (2017) Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mechanisms of Development. 143:42-52
Liu, X., Cai, X., Zhang, D., Xu, C., Xiao, W. (2016) Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 197(12):4736-4749
Liu, X., Cai, X., Hu, B., Mei, Z., Zhang, D., Ouyang, G., Wang, J., Zhang, W., Xiao, W. (2016) Forkhead transcription factor 3a (FOXO3a) modulates hypoxia signaling via up-regulation of von Hippel-Lindau gene (VHL). The Journal of biological chemistry. 291(49):25692-25705
Du, J., Zhang, D., Zhang, W., Ouyang, G., Wang, J., Liu, X., Li, S., Ji, W., Liu, W., Xiao, W. (2015) pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. Journal of immunology (Baltimore, Md. : 1950). 195(4):1782-90
Guan, L., Chi, W., Xiao, W., Chen, L., He, S. (2014) Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan Plateau in the evolution of schizothoracine fish. BMC Evolutionary Biology. 14:192
Hu, B., Zhang, W., Feng, X., Ji, W., Xie, X., and Xiao, W. (2014) Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis. Developmental Biology. 388(1):81-93
Liu, J.X., Zhang, D., Xie, X., Ouyang, G., Liu, X., Sun, Y., and Xiao, W. (2013) Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling. Development (Cambridge, England). 140(5):1067-1078
Wan, X., Hu, B., Liu, J.X., Feng, X., and Xiao, W. (2011) Zebrafish mll is essential for haematopoiesis. The Journal of biological chemistry. 286(38):33345-57
Feng, X., Liu, X., Zhang, W., and Xiao, W. (2011) p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. The EMBO journal. 30(16):3397-415
Xie, X.W., Liu, J.X., Hu, B., and Xiao, W. (2011) Zebrafish foxo3b Negatively Regulates Canonical Wnt Signaling to Affect Early Embryogenesis. PLoS One. 6(9):e24469
Wan, X., Ji, W., Mei, X., Zhou, J., Liu, J.X., Fang, C., and Xiao, W. (2010) Negative Feedback Regulation of Wnt4 Signaling by EAF1 and EAF2/U19. PLoS One. 5(2):e9118
Zhou, J., Feng, X., Ban, B., Liu, J., Wang, Z., and Xiao, W. (2009) The elongation factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. The Journal of biological chemistry. 284(28):19142-19152
Liu, J.X., Hu, B., Wang, Y., Gui, J.F., and Xiao, W. (2009) Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. The Journal of biological chemistry. 284(24):16679-16692

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