ZFIN ID: ZDB-PERS-050131-1
Renshaw, Steve A.
Email: s.a.renshaw@sheffield.ac.uk
URL: https://www.sheffield.ac.uk/iicd/profiles/renshaw
Affiliation: Renshaw Sheffield Lab
Address: Renshaw Laboratory, D39 Bateson Centre Firth Court Western Bank Sheffield, S10 2TN United Kingdom
Country: United Kingdom
Phone: +44 114 222 2334
Fax: +44 114 276 5413

2018 marks my 20th year at the University of Sheffield. I am the Sir Arthur Hall Professor of Medicine and Director of the Bateson Centre - a large cross-faculty research centre (former MRC Centre, 41PIs, over 130 members and active grant funding of over £30m). I have important leadership roles in large cross-institution partnerships, including directing an MRC Doctoral Training Partnership across 4 major civic universities of the North of England – highly regarded as a model for student-led, cross-institutional, innovative postgraduate research training. I also have national and International leadership roles through membership of REF 2021 sub-panel 1, and through being a board member of Zebrafish Disease Models Society and principal organiser of Neutrophil 2020 – the foremost international neutrophil biology meeting. I studied medicine at Cambridge and then at Oxford Clinical School. After a clinical rotation in Nottingham, I moved to Sheffield to take up a Wellcome Trust Clinical Research Training Fellowship, to work on the regulation of neutrophil lifespan with Professor Moira Whyte. After 3 years as Clinical Lecturer in Respiratory Medicine, I was awarded an MRC Clinician Scientist Fellowship to develop an innovative model of neutrophil biology in the transparent, genetically tractable larval zebrafish. I have been able to develop a number of unique transgenic zebrafish which have allowed several important advances in our understanding of inflammation biology and of host-pathogen interaction. In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work. I continue clinical work in Respiratory Medicine with a special interest in Interstitial Lung Disease associated with a range of multisystem diseases.

Research Interests: Diseases of immunity cause much illness in the developed world – on one hand we are beset by a range of antibiotic resistance bacterial infections, while on the other hand our immune systems are responsible for many the common diseases of ageing – heart disease, stroke and COPD. Understanding the regulation of innate immune cells, neutrophils and macrophages, in infection and inflammation will help us tune the immune system to the exact level needed to cope with the current level of threat. More host defence to fight antibiotic resistant organisms; less host defence to prevent lung damage in response to environmental pollutants. To improve our understanding, I have set up a model system in which the genes controlling regulation of innate immune cell function can be identified. The model I have chosen is the Zebrafish, which is both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence host-pathogen interaction and the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an infection or an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease.

Herman, K.D., Wright, C.G., Marriott, H.M., McCaughran, S.C., Bowden, K.A., Collins, M.O., Renshaw, S.A., Prince, L.R. (2022) The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages. Frontiers in immunology. 13:956991
Ellis, P.S., Martins, R.R., Thompson, E.J., Farhat, A., Renshaw, S.A., Henriques, C.M. (2022) A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish. Immunity & ageing : I & A. 19:31
Gibson, J.F., Bojarczuk, A., Evans, R.J., Kamuyango, A.A., Hotham, R., Lagendijk, A.K., Hogan, B.M., Ingham, P.W., Renshaw, S.A., Johnston, S.A. (2022) Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection. PLoS pathogens. 18:e1010389
Le Moigne, V., Rodriguez Rincon, D., Glatigny, S., Dupont, C.M., Langevin, C., Ait Ali Said, A., Renshaw, S.A., Floto, R.A., Herrmann, J.L., Bernut, A. (2022) Roscovitine Worsens Mycobacterium abscessus Infection by Reducing DUOX2-Mediated Neutrophil Response. American journal of respiratory cell and molecular biology. 66(4):439-451
Gibson, J.F., Pidwill, G.R., Carnell, O.T., Surewaard, B.G.J., Shamarina, D., Sutton, J.A.F., Jeffery, C., Derré-Bobillot, A., Archambaud, C., Siggins, M.K., Pollitt, E.J.G., Johnston, S.A., Serror, P., Sriskandan, S., Renshaw, S.A., Foster, S.J. (2021) Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species. PLoS pathogens. 17:e1009880
Sutton, J.A.F., Carnell, O.T., Lafage, L., Gray, J., Biboy, J., Gibson, J.F., Pollitt, E.J.G., Tazoll, S.C., Turnbull, W., Hajdamowicz, N.H., Salamaga, B., Pidwill, G.R., Condliffe, A.M., Renshaw, S.A., Vollmer, W., Foster, S.J. (2021) Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS pathogens. 17:e1009468
Buchan, K.D., van Gent, M., Prajsnar, T.K., Ogryzko, N.V., de Jong, N.W.M., Kolata, J., Foster, S.J., van Strijp, J.A.G., Renshaw, S.A. (2021) Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. Journal of Cell Science. 134(5):
Foulkes, M.J., Tolliday, F.H., Henry, K.M., Renshaw, S.A., Jones, S. (2020) Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish. PLoS One. 15:e0240231
Bernut, A., Loynes, C.A., Floto, R.A., Renshaw, S.A. (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Frontiers in immunology. 11:1733
Gibson, J.F., Prajsnar, T.K., Hill, C.J., Tooke, A.K., Serba, J.J., Tonge, R.D., Foster, S.J., Grierson, A.J., Ingham, P.W., Renshaw, S.A., Johnston, S.A. (2020) Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. 17(6):1448-1457
Fenaroli, F., Robertson, J.D., Scarpa, E., Gouveia, V.M., Di Guglielmo, C., De Pace, C., Elks, P.M., Poma, A., Evangelopoulos, D., Ortiz Canseco, J., Marriott, H.M., Dockrell, D.H., Foster, S., McHugh, T.D., Renshaw, S.A., Samitier Marti, J., Battaglia, G., Rizzello, L. (2020) Polymersomes Eradicating Intracellular Bacteria. ACS nano. 14(7):8287-8298
Hamilton, N., Rutherford, H.A., Petts, J.J., Isles, H.M., Weber, T., Henneke, M., Gärtner, J., Dunning, M.J., Renshaw, S.A. (2020) The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. 68(7):1531-1545
Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237
Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902
Batalha, I.L., Bernut, A., Schiebler, M., Ouberai, M.M., Passemar, C., Klapholz, C., Kinna, S., Michel, S., Sader, K., Castro-Hartmann, P., Renshaw, S.A., Welland, M.E., Andres Floto, R. (2019) Polymeric nanobiotics as a novel treatment for mycobacterial infections. Journal of controlled release : official journal of the Controlled Release Society. 314:116-124
Rahman, A., Henry, K.M., Herman, K.D., Thompson, A.A.R., Isles, H.M., Tulotta, C., Sammut, D., Rougeot, J.J., Khoshaein, N., Reese, A.E., Higgins, K., Tabor, C., Sabroe, I., Zuercher, W.J., Savage, C.O., Meijer, A.H., Whyte, M.K., Dockrell, D.H., Renshaw, S.A., Prince, L.R. (2019) Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. eLIFE. 8
Isles, H.M., Herman, K.D., Robertson, A.L., Loynes, C.A., Prince, L.R., Elks, P.M., Renshaw, S.A. (2019) The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish. Frontiers in immunology. 10:1784
Buchan, K.D., Prajsnar, T.K., Ogryzko, N.V., de Jong, N.W.M., van Gent, M., Kolata, J., Foster, S.J., van Strijp, J.A.G., Renshaw, S.A. (2019) A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase. PLoS One. 14:e0215592
Evans, R.J., Pline, K., Loynes, C.A., Needs, S., Aldrovandi, M., Tiefenbach, J., Bielska, E., Rubino, R.E., Nicol, C.J., May, R.C., Krause, H.M., O'Donnell, V.B., Renshaw, S.A., Johnston, S.A. (2019) 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS pathogens. 15:e1007597
Bernut, A., Dupont, C., Ogryzko, N.V., Neyret, A., Herrmann, J.L., Floto, R.A., Renshaw, S.A., Kremer, L. (2019) CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses. Cell Reports. 26:1828-1840.e4
Ogryzko, N.V., Lewis, A., Wilson, H.L., Meijer, A.H., Renshaw, S.A., Elks, P.M. (2018) Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 202(2):494-502
Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320
Hamilton, N., Sabroe, I., Renshaw, S.A. (2018) A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research. 7:594
Prajsnar, T.K., McVicker, G., Williams, A., Renshaw, S.A., Foster, S.J. (2018) Use of Larval Zebrafish Model to Study Within-Host Infection Dynamics. Methods in molecular biology (Clifton, N.J.). 1736:147-156
Connolly, J., Boldock, E., Prince, L.R., Renshaw, S.A., Whyte, M.K., Foster, S.J. (2017) The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood. Infection and Immunity. 85(11)
Prince, L.R., Dannewitz Prosseda, S., Higgins, K., Carlring, J., Prestwich, E.C., Ogryzko, N.V., Rahman, A., Basran, A., Falciani, F., Taylor, P., Renshaw, S.A., Whyte, M.K.B., Sabroe, I. (2017) NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood. 130(8):1014-1025
Salamaga, B., Prajsnar, T.K., Jareño-Martinez, A., Willemse, J., Bewley, M.A., Chau, F., Ben Belkacem, T., Meijer, A.H., Dockrell, D.H., Renshaw, S.A., Mesnage, S. (2017) Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis. PLoS pathogens. 13:e1006526
Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
Robertson, J.D., Ward, J.R., Avila-Olias, M., Battaglia, G., Renshaw, S.A. (2017) Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery. Journal of immunology (Baltimore, Md. : 1950). 198(9):3596-3604
Lee, J.A., Renshaw, S.A. (2017) Zebrafish screens for new colitis treatments - a bottom-up approach. The FEBS journal. 284:399-401
Robertson, A.L., Ogryzko, N.V., Henry, K.M., Loynes, C.A., Foulkes, M.J., Meloni, M.M., Wang, X., Ford, C., Jackson, M., Ingham, P.W., Wilson, H.L., Farrow, S.N., Solari, R., Flower, R.J., Jones, S., Whyte, M.K., Renshaw, S.A. (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Disease models & mechanisms. 9(6):621-32
Bojarczuk, A., Miller, K.A., Hotham, R., Lewis, A., Ogryzko, N.V., Kamuyango, A.A., Frost, H., Gibson, R.H., Stillman, E., May, R.C., Renshaw, S.A., Johnston, S.A. (2016) Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection. Scientific Reports. 6:21489
Keatinge, M., Bui, H., Menke, A., Chen, Y.C., Sokol, A.M., Bai, Q., Ellett, F., Da Costa, M., Burke, D., Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.S., Fleming, A., Schapira, A.H., Renshaw, S.A., Highley, J.R., Chacinska, A., Panula, P., Burton, E.A., O'Neill, M.J., Bandmann, O. (2015) Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Human molecular genetics. 24(23):6640-52
Ellett, F., Elks, P.M., Robertson, A.L., Ogryzko, N.V., Renshaw, S.A. (2015) Defining the phenotype of neutrophils following reverse migration in zebrafish. Journal of Leukocyte Biology. 98(6):975-81
Messad, N., Prajsnar, T.K., Lina, G., O'Callaghan, D., Foster, S.J., Renshaw, S.A., Skaar, E.P., Bes, M., Dunyach-Remy, C., Vandenesch, F., Sotto, A., Lavigne, J.P. (2015) Existence of a Colonizing Staphylococcus aureus Strain Isolated in Diabetic Foot Ulcers. Diabetes. 64:2991-5
Schiebler, M., Brown, K., Hegyi, K., Newton, S.M., Renna, M., Hepburn, L., Klapholz, C., Coulter, S., Obregón-Henao, A., Henao Tamayo, M., Basaraba, R., Kampmann, B., Henry, K.M., Burgon, J., Renshaw, S.A., Fleming, A., Kay, R.R., Anderson, K.E., Hawkins, P.T., Ordway, D.J., Rubinsztein, D.C., Floto, R.A. (2015) Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. EMBO Molecular Medicine. 7(2):127-39
Hepburn, L., Prajsnar, T.K., Klapholz, C., Moreno, P., Loynes, C.A., Ogryzko, N.V., Brown, K., Schiebler, M., Hegyi, K., Antrobus, R., Hammond, K.L., Connolly, J., Ochoa, B., Bryant, C., Otto, M., Surewaard, B., Seneviratne, S.L., Grogono, D.M., Cachat, J., Ny, T., Kaser, A., Török, M.E., Peacock, S.J., Holden, M., Blundell, T., Wang, L., Ligoxygakis, P., Minichiello, L., Woods, C.G., Foster, S.J., Renshaw, S.A., Floto, R.A. (2014) Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science (New York, N.Y.). 346:641-6
Ogryzko, N.V., Renshaw, S.A., Wilson, H.L. (2014) The IL-1 family in fish: Swimming through the muddy waters of inflammasome evolution. Developmental and comparative immunology. 46(1):53-62
Candel, S., de Oliveira, S., López-Muñoz, A., García-Moreno, D., Espín-Palazón, R., Tyrkalska, S.D., Cayuela, M.L., Renshaw, S.A., Corbalán-Vélez, R., Vidal-Abarca, I., Tsai, H.J., Meseguer, J., Sepulcre, M.P., Mulero, V. (2014) Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biology. 12:e1001855
McVicker, G., Prajsnar, T.K., Williams, A., Wagner, N.L., Boots, M., Renshaw, S.A., Foster, S.J. (2014) Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. PLoS pathogens. 10:e1003959
Robertson, A.L., Holmes, G.R., Bojarczuk, A.N., Burgon, J., Loynes, C.A., Chimen, M., Sawtell, A.K., Hamza, B., Willson, J., Walmsley, S.R., Anderson, S.R., Coles, M.C., Farrow, S.N., Solari, R., Jones, S., Prince, L.R., Irimia, D., Rainger, G.E., Kadirkamanathan, V., Whyte, M.K., Renshaw, S.A. (2014) A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Science Translational Medicine. 6:225ra29
Burgon, J., Robertson, A.L., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L.R., Walker, P., Hoggett, E.E., Ward, J.R., Farrow, S.N., Zuercher, W.J., Jeffrey, P., Savage, C.O., Ingham, P.W., Hurlstone, A.F., Whyte, M.K., and Renshaw, S.A. (2014) Serum and Glucocorticoid-Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution. Journal of immunology (Baltimore, Md. : 1950). 192(4):1796-1805
Ogryzko, N.V., Hoggett, E.E., Solaymani-Kohal, S., Tazzyman, S., Chico, T.J., Renshaw, S.A., and Wilson, H.L. (2014) Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms. 7(2):259-64
Thompson, A.A., Elks, P.M., Marriott, H.M., Eamsamarng, S., Higgins, K.R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E.E., Formenti, F., Van Eeden, F.J., Kinnula, V.L., Pugh, C.W., Sabroe, I., Dockrell, D.H., Chilvers, E.R., Robbins, P.A., Percy, M.J., Simon, M.C., Johnson, R.S., Renshaw, S.A., Whyte, M.K., and Walmsley, S.R. (2014) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 123(3):366-76
Wang, X., Robertson, A.L., Li, J., Chai, R.J., Haishan, W., Sadiku, P., Ogryzko, N.V., Everett, M., Yoganathan, K., Luo, H.R., Renshaw, S.A., and Ingham, P.W. (2014) Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Disease models & mechanisms. 7(1):163-169
Prajsnar, T.K., Renshaw, S.A., Ogryzko, N.V., Foster, S.J., Serror, P., and Mesnage, S. (2013) Zebrafish as a novel vertebrate model to dissect enterococcal pathogenesis. Infection and Immunity. 81(11):4271-4279
Henry, K.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2013) Zebrafish as a model for the study of neutrophil biology. Journal of Leukocyte Biology. 94(4):633-642
Henry, K.M., Pase, L., Ramos-Lopez, C.F., Lieschke, G.J., Renshaw, S.A., and Reyes-Aldasoro, C.C. (2013) PhagoSight: An Open-Source MATLAB® Package for the Analysis of Fluorescent Neutrophil and Macrophage Migration in a Zebrafish Model. PLoS One. 8(8):e72636
de Oliveira, S., Reyes-Aldasoro, C.C., Candel, S., Renshaw, S.A., Mulero, V., and Calado, A. (2013) Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response. Journal of immunology (Baltimore, Md. : 1950). 190(8):4349-59
Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., and North, T.E. (2013) Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo. Blood. 121(13):2483-2493
Elks, P.M., Brizee, S., van der Vaart, M., Walmsley, S.R., van Eeden, F.J., Renshaw, S.A., and Meijer, A.H. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS pathogens. 9(12):e1003789
Holmes, G.R., Anderson, S.R., Dixon, G., Renshaw, S.A., and Kadirkamanathan, V. (2013) A Bayesian framework for identifying cell migration dynamics. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2013:3455-3458
Holmes, G.R., Anderson, S.R., Dixon, G., Robertson, A.L., Reyes-Aldasoro, C.C., Billings, S.A., Renshaw, S.A., and Kadirkamanathan, V. (2012) Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling. Journal of the Royal Society, Interface. 9(77):3229-3239
Pase, L., Layton, J.E., Wittmann, C., Ellett, F., Nowell, C.J., Reyes-Aldasoro, C.C., Varma, S., Rogers, K.L., Hall, C.J., Keightley, M.C., Crosier, P.S., Grabher, C., Heath, J.K., Renshaw, S.A., and Lieschke, G.J. (2012) Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish. Current biology : CB. 22(19):1818-1824
Prajsnar, T.K., Hamilton, R., Garcia-Lara, J., McVicker, G., Williams, A., Boots, M., Foster, S.J., and Renshaw, S.A. (2012) A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model. Cellular Microbiology. 14(10):1600-1619
Santhakumar, K., Judson, E.C., Elks, P.M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S.S., Renshaw, S., Cross, S.S., and van Eeden, F.J. (2012) A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer research. 72(16):4017-4027
Feng, Y., Renshaw, S., and Martin, P. (2012) Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE(2). Current biology : CB. 22(13):1253-1259
Renshaw, S.A., and Trede, N.S. (2012) A model 450 million years in the making: zebrafish and vertebrate immunity. Disease models & mechanisms. 5(1):38-47
Holmes, G.R., Dixon, G., Anderson, S.R., Reyes-Aldasoro, C.C., Elks, P.M., Billings, S.A., Whyte, M.K., Kadirkamanathan, V., and Renshaw, S.A. (2012) Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in hematology. 2012:792163
Dixon, G., Elks, P.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2012) A Method for the In Vivo Measurement of Zebrafish Tissue Neutrophil Lifespan. ISRN Hematology. 2012:915868
Kadirkamanathan, V., Anderson, S.R., Billings, S.A., Zhang, X., Holmes, G.R., Reyes-Aldasoro, C.C., Elks, P.M., and Renshaw, S.A. (2012) The Neutrophil's Eye-View: Inference and Visualisation of the Chemoattractant Field Driving Cell Chemotaxis In Vivo. PLoS One. 7(4):e35182
Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60
Colucci-Guyon, E., Tinevez, J.Y., Renshaw, S.A., and Herbomel, P. (2011) Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes. Journal of Cell Science. 124(Pt 18):3053-9
Elks, P.M., van Eeden, F.J., Dixon, G., Wang, X., Reyes-Aldasoro, C.C., Ingham, P.W., Whyte, M.K., Walmsley, S.R., and Renshaw, S.A. (2011) Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model. Blood. 118(3):712-22
Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819
Elks, P.M., Loynes, C.A., and Renshaw, S.A. (2011) Measuring Inflammatory Cell Migration in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 769:261-275
Renshaw, S.A., and Ingham, P.W. (2010) Zebrafish models of the immune response: taking it on the ChIn. BMC Biology. 8(1):148
Vergunst, A.C., Meijer, A.H., Renshaw, S.A., and O'Callaghan, D. (2010) Burkholderia cenocepacia creates an intra-macrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection. Infection and Immunity. 78(4):1495-1508
Loynes, C.A., Martin, J.S., Robertson, A., Trushell, D.M., Ingham, P.W., Whyte, M.K., and Renshaw, S.A. (2010) Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. Journal of Leukocyte Biology. 87(2):203-212
Brugman, S., Liu, K.Y., Lindenbergh-Kortleve, D., Samsom, J.N., Furuta, G.T., Renshaw, S.A., Willemsen, R., and Nieuwenhuis, E.E. (2009) Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota. Gastroenterology. 137(5):1757.e1-1767.e1
Martin, J.S., and Renshaw, S.A. (2009) Using in vivo zebrafish models to understand the biochemical basis of neutrophilic respiratory disease. Biochemical Society transactions. 37(Pt 4):830-837
Prajsnar, T.K., Cunliffe, V.T., Foster, S.J., and Renshaw, S.A. (2008) A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens. Cellular Microbiology. 10(11):2312-2325
Roca, F.J., Mulero, I., López-Muñoz, A., Sepulcre, M.P., Renshaw, S.A., Meseguer, J., and Mulero, V. (2008) Evolution of the Inflammatory Response in Vertebrates: Fish TNF-{alpha} Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 181(7):5071-5081
Renshaw, S.A., Loynes, C.A., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2007) Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Experimental Lung Research. 33(10):549-554
Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210
Renshaw, S.A., Loynes, C.A., Trushell, D.M., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2006) A transgenic zebrafish model of neutrophilic inflammation. Blood. 108(13):3976-3978

1. Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation. David J Wardle, Joseph Burgon, Ian Sabroe, Colin D Bingle, Moira KB Whyte, Stephen A Renshaw PLoS ONE 2011 6(1) e15768

2. Regulation of Neutrophil Senescence by MicroRNAs. Jon R. Ward, Paul R. Heath, Marta Milo, James W. Catto, Moira K.B. Whyte, Stephen A. Renshaw. PLoS ONE 2011 6(1) e15810

3. Dick EP, Prince LR, Prestwich EC, Renshaw SA, Whyte MK, Sabroe I. Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils. Immunology. 2008 Oct 28.

4. Identifying and hurdling obstacles to translational research. Ian Sabroe, David H. Dockrell, Stefanie N. Vogel, Stephen A. Renshaw, Moira K. B. Whyte and Steven K. Dower. Nature Reviews Immunology 2007, 2007; 7(1):77-82.

5. Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Stephen M Bianchi, David H Dockrell, Stephen A Renshaw, Ian Sabroe, Moira KB Whyte. Clinical Science March 2006; 110(3):293-304

6. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. Clare E. Dempsey, Caroline Dive, Daniel J. Fletcher, Frances A. Barnes, Alan Lobo, Colin D. Bingle, Moira K.B. Whyte, and Stephen A. Renshaw. FEBS Letters July 2005; 579 (17): 3646-3650

7. Three Novel Bid Proteins Generated By Alternative Splicing Of The Human Bid Gene. Stephen A. Renshaw, Clare E. Dempsey, Stephanie M. Bagstaff, Frances A. Barnes, Steven K. Dower, Colin D. Bingle, and Moira K.B. Whyte. Journal of Biological Chemistry Jan 2004; 279: 2846 - 2855.

8. Acceleration of Human Neutrophil Apoptosis by TRAIL. Stephen A. Renshaw, Jasvir S. Parmar, Vanessa Singleton, Sarah J. Rowe, David H. Dockrell, Steven K. Dower, Colin D. Bingle, Edwin R. Chilvers, and Moira K. B. Whyte Journal of Immunology 170 (2) January 2003 1027-1033.

9. Inflammatory neutrophils retain susceptibility to apoptosis mediated via the Fas death receptor. Stephen A. Renshaw, Samantha J. Timmons, Vanessa Eaton, Lynne R. Usher, Mohammed Akil, Colin D. Bingle, Moira K.B. Whyte. Journal of Leukocyte Biology 2000 67:662-668.

10. Apoptosis and the regulation of neutrophil lifespan. Moira K.B. Whyte, Stephen A. Renshaw, Roderick A. Lawson and Colin D. Bingle Biochemical Society Transactions 1999 27:802-807