ZFIN ID: ZDB-PERS-010515-11
Elworthy, Stone
Email: s.elworthy@sheffield.ac.uk
Address: MRC Centre Development for Developmental and Biomedical Genetics, University of Sheffield Firth Court Western Bank Sheffield, S10 2TN United Kingdom
Phone: 44-(0)114-222-2769
Fax: 44-(0)114-222-2788

I'm investigating embryonic muscle development especially how slow muscle is specified by the hedgehog signalling pathway. I previously worked on neural crest development in Robert Kelsh's lab in Bath.

Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 248(6):410-425
Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
Jackson, H.E., Ono, Y., Wang, X., Elworthy, S., Cunliffe, V.T., Ingham, P.W. (2015) The role of Sox6 in zebrafish muscle fiber type specification. Skeletal muscle. 5:2
Wilkinson, R.N., Elworthy, S., Ingham, P.W., and van Eeden, F.J. (2013) A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies. Biotechniques. 55(6):314-316
Maurya, A.K., Ben, J., Zhao, Z., Lee, R.T., Niah, W., Ng, A.S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F.J., and Ingham, P.W. (2013) Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genetics. 9(12):e1003955
Santhakumar, K., Judson, E.C., Elks, P.M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S.S., Renshaw, S., Cross, S.S., and van Eeden, F.J. (2012) A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer research. 72(16):4017-4027
Ben, J., Elworthy, S., Ng, A.S., van Eeden, F., and Ingham, P.W. (2011) Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (Cambridge, England). 138(22):4969-4978
Seger, C., Hargrave, M., Wang, X., Chai, R.J., Elworthy, S., and Ingham, P.W. (2011) Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease. Developmental dynamics : an official publication of the American Association of Anatomists. 240(11):2440-51
von Hofsten, J., Elworthy, S., Gilchrist, M.J., Smith, J.C., Wardle, F.C., and Ingham, P.W. (2008) Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO reports. 9(7):683-689
Elworthy, S., Hargrave, M., Knight, R., Mebus, K., and Ingham, P.W. (2008) Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity. Development (Cambridge, England). 135(12):2115-2126
Renshaw, S.A., Loynes, C.A., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2007) Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Experimental Lung Research. 33(10):549-554
Svetic, V., Hollway, G.E., Elworthy, S., Chipperfield, T.R., Davison, C., Adams, R.J., Eisen, J.S., Ingham, P.W., Currie, P.D., and Kelsh, R.N. (2007) Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants. Development (Cambridge, England). 134(5):1011-1022
Renshaw, S.A., Loynes, C.A., Trushell, D.M., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2006) A transgenic zebrafish model of neutrophilic inflammation. Blood. 108(13):3976-3978
Elworthy, S., Pinto, J.P., Pettifer, A., Cancela, M.L., and Kelsh, R.N. (2005) Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mechanisms of Development. 122(5):659-669
Shepherd, I.T., Pietsch, J., Elworthy, S., Kelsh, R.N., and Raible, D.W. (2004) Roles for GFRalpha1 receptors in zebrafish enteric nervous system development. Development (Cambridge, England). 131(1):241-249
Elworthy, S., Lister, J.A., Carney, T.J., Raible, D.W., and Kelsh, R.N. (2003) Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development. Development (Cambridge, England). 130:2809-2818
Lister, J.A., Elworthy, S., Raible, D.W., and Kelsh, R.N. (2002) Direct regulation of the neural crest promoter of zebrafish nacre/mitfa by colourless/Sox10. Pigm. Cell Res.. 15(9):28
Dutton, K.A., Pauliny, A., Lopes, S.S., Elworthy, S., Carney, T.J., Rauch, J., Geisler, R., Haffter, P., and Kelsh, R.N. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development (Cambridge, England). 128(21):4113-4125

He YY, Garvie CW, Elworthy S, Manfield IW, McNally T, Lawrenson ID, Phillips SE, Stockley PG.
Structural and functional studies of an intermediate on the pathway to operator binding by Escherichia coli MetJ.
J Mol Biol. 2002 Jun 28;320(1):39-53.