ZFIN Person: Baxendale, Sarah

ZFIN ID: ZDB-PERS-001220-2

Baxendale, Sarah

Email:	s.baxendale@sheffield.ac.uk
URL:
Affiliation:	Whitfield Lab
Address:	MRC Centre Development for Developmental and Biomedical Genetics, University of Sheffield Firth Court Western Bank Sheffield, S10 2TN United Kingdom
Country:	United Kingdom
Phone:	44-114-222-2803
Fax:	44-114-222-2788
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Asad, A., Shahidan, N.O., de la Vega de León, A., Wiggin, G.R., Whitfield, T.T., Baxendale, S. (2023) A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos. Basic & Clinical Pharmacology & Toxicology. 133(4):364-377

Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835

Baldera, D., Baxendale, S., van Hateren, N.J., Marzo, M., Glendenning, E., Geng, F.S., Yokoya, K., Knight, R.D., Whitfield, T.T. (2023) Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear. Journal of anatomy. 243(1):78-89

Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624

Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727

Mendonca, T., Jones, A.A., Pozo, J.M., Baxendale, S., Whitfield, T.T., Frangi, A.F. (2021) Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data. PLoS Computational Biology. 17:e1009063

Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., Goodyear, R.J., Derudas, M., Cantillon, D.M., Baxendale, S., de la Vega de León, A., Mahieu, V.N., Osgood, R.T., Donald Wilson, C., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2021) Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI insight. 6(7)

Baxendale, S., Asad, A., Shahidan, N.O., Wiggin, G.R., Whitfield, T.T. (2021) The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model. Genesis (New York, N.Y. : 2000). 59(4):e23417

Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T. (2021) Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection. Frontiers in Physiology. 12:626080

Jones, A., Barker-Haliski, M., Ilie, A.S., Herd, M.B., Baxendale, S., Holdsworth, C.J., Ashton, J.P., Placzek, M., Jayasekera, B.A.P., Cowie, C.J.A., Lambert, J.J., Trevelyan, A.J., White, H.S., Marson, A.G., Cunliffe, V.T., Sills, G.J., Morgan, A. (2020) A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 61(10):2106-2118

Toms, M., Dubis, A.M., de Vrieze, E., Tracey-White, D., Mitsios, A., Hayes, M., Broekman, S., Baxendale, S., Utoomprurkporn, N., Bamiou, D., Bitner-Glindzicz, M., Webster, A.R., Van Wijk, E., Moosajee, M. (2020) Clinical and preclinical therapeutic outcome metrics for USH2A-related disease. Human molecular genetics. 29(11):1882-1899

Diamantopoulou, E., Baxendale, S., de la Vega de León, A., Asad, A., Holdsworth, C.J., Abbas, L., Gillet, V.J., Wiggin, G.R., Whitfield, T.T. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. eLIFE. 8:

Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051

Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., O'Reilly, M., Derudas, M., Cantillon, D.M., Goodyear, R.J., Secker, A., Baxendale, S., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI insight. 2(24)

Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735

Baxendale, S., van Eeden, F., Wilkinson, R. (2017) The Power of Zebrafish in Personalised Medicine. Advances in experimental medicine and biology. 1007:179-197

Baxendale, S., Whitfield, T.T. (2016) Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course. Methods in cell biology. 134:165-209

Stooke-Vaughan, G.A., Obholzer, N.D., Baxendale, S., Megason, S.G., Whitfield, T.T. (2015) Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Development (Cambridge, England). 142(6):1137-45

Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374

Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784

Thompson, M.J., Louth, J.C., Ferrara, S., Jackson, M.P., Sorrell, F.J., Cochrane, E.J., Gever, J., Baxendale, S., Silber, B.M., Roehl, H.H., and Chen, B. (2011) Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity. European Journal of Medicinal Chemistry. 46(9):4125-32

Baxendale, S., Chen, C.K., Tang, H., Davison, C., Hateren, L.V., Croning, M.D., Humphray, S.J., Hubbard, S.J., and Ingham, P.W. (2009) Expression screening and annotation of a zebrafish myoblast cDNA library. Gene expression patterns : GEP. 9(2):73-82

Hammond, K.L., Baxendale, S., McCauley, D.W., Ingham, P.W., and Whitfield, T.T. (2009) Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evolution & development. 11(1):27-40

Baxendale, S., Davison, C., Muxworthy, C., Wolff, C., Ingham, P.W., and Roy, S. (2004) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nature Genetics. 36(1):88-93

NON-ZEBRAFISH PUBLICATIONS