Morpholino

MO2-vhl

ID
ZDB-MRPHLNO-130514-1
Name
MO2-vhl
Previous Names
  • vhl-ATG (1)
Target
Sequence
5' - GGCATCGTCAAAGACAGGACAGTTC - 3'
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
Translation-blocking MO.
Genome Resources
None
Target Location
Genomic Features
No data available
Expression
Gene expression in Wild Types + MO2-vhl
Expressed Gene Anatomy Figures
epor Fig. 4 from Chen et al., 2015
kdrl Fig. 4,  Fig. 5 from Chen et al., 2015
myb Fig. 2 from Lim et al., 2017
pdgfba Fig. 1 from Lim et al., 2017
pdgfrb Fig. 1 from Lim et al., 2017
runx1 Fig. 2 from Lim et al., 2017
vegfaa Fig. 4,  Fig. 5 from Chen et al., 2015
Phenotype
Phenotype resulting from MO2-vhl
Phenotype Fish Figures
blood increased accumulation yolk, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
dorsal aorta dilated, abnormal WT + MO2-vhl Fig. 5 from Chen et al., 2015
glomerular filtration disrupted, abnormal WT + MO2-vhl Fig. 2 from Chen et al., 2015
hematopoietic multipotent progenitor cell increased amount, abnormal la2Tg; sd2Tg + MO2-vhl Fig. 2 from Lim et al., 2017
lateral dorsal aorta dilated, abnormal WT + MO2-vhl Fig. 5 from Chen et al., 2015
muscle mitophagy increased occurrence, abnormal zf3335Tg + MO2-vhl Fig. 6 from Wrighton et al., 2021
podocyte vegfaa expression increased amount, abnormal WT + MO2-vhl Fig. 5 from Chen et al., 2015
pronephric duct curved, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric duct cystic, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric glomerulus atrophied, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric glomerulus cystic, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric glomerulus disorganized, abnormal WT + MO2-vhl Fig. 3 from Chen et al., 2015
pronephric glomerulus increased size, abnormal WT + MO2-vhl Fig. 5 from Chen et al., 2015
pronephric glomerulus swollen, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric glomerulus bicellular tight junction decreased amount, abnormal WT + MO2-vhl Fig. 3 from Chen et al., 2015
pronephric tubule curved, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric tubule cystic, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephric tubule distended, abnormal li1Tg + MO2-vhl Fig. 1 from Chen et al., 2015
pronephros decreased functionality, abnormal WT + MO2-vhl Fig. 2 from Chen et al., 2015
pronephros shape, abnormal WT + MO2-vhl Fig. 5 from Chen et al., 2015
pronephros development disrupted, abnormal li1Tg + MO2-vhl Fig. 1,  Fig. 5 from Chen et al., 2015
subintestinal vein increased branchiness, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
subintestinal vein spatial pattern, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
subintestinal vein sprouting angiogenesis increased occurrence, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal WT + MO2-vhl Fig. 2 from Lim et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal WT + MO2-vhl Fig. 2 from Lim et al., 2017
whole organism kdrl expression increased amount, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
whole organism pdgfba expression increased amount, abnormal WT + MO2-vhl Fig. 1 from Lim et al., 2017
whole organism pdgfrb expression increased amount, abnormal WT + MO2-vhl Fig. 1 from Lim et al., 2017
whole organism epor expression increased amount, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
whole organism vegfaa expression increased amount, abnormal WT + MO2-vhl Fig. 4 from Chen et al., 2015
Phenotype of all Fish created by or utilizing MO2-vhl
Phenotype Fish Conditions Figures
ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal WT + MO2-vhl control Fig. 2 from Lim et al., 2017
subintestinal vein spatial pattern, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
subintestinal vein sprouting angiogenesis increased occurrence, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
whole organism epor expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
subintestinal vein increased branchiness, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
pronephros shape, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
pronephric glomerulus bicellular tight junction decreased amount, abnormal WT + MO2-vhl standard conditions Fig. 3 from Chen et al., 2015
podocyte vegfaa expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
whole organism pdgfrb expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 1 from Lim et al., 2017
glomerular filtration disrupted, abnormal WT + MO2-vhl standard conditions Fig. 2 from Chen et al., 2015
blood increased accumulation yolk, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
whole organism pdgfba expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 1 from Lim et al., 2017
pronephros development disrupted, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
pronephric glomerulus increased size, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
pronephric glomerulus disorganized, abnormal WT + MO2-vhl standard conditions Fig. 3 from Chen et al., 2015
lateral dorsal aorta dilated, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
whole organism kdrl expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
dorsal aorta dilated, abnormal WT + MO2-vhl standard conditions Fig. 5 from Chen et al., 2015
whole organism vegfaa expression increased amount, abnormal WT + MO2-vhl standard conditions Fig. 4 from Chen et al., 2015
pronephros decreased functionality, abnormal WT + MO2-vhl standard conditions Fig. 2 from Chen et al., 2015
ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal WT + MO2-vhl control Fig. 2 from Lim et al., 2017
pronephric tubule distended, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric glomerulus cystic, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric duct curved, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric glomerulus atrophied, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric tubule cystic, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric glomerulus swollen, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephros development disrupted, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric duct cystic, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
pronephric tubule curved, abnormal li1Tg + MO2-vhl standard conditions Fig. 1 from Chen et al., 2015
muscle mitophagy increased occurrence, abnormal zf3335Tg + MO2-vhl standard conditions Fig. 6 from Wrighton et al., 2021
hematopoietic multipotent progenitor cell increased amount, abnormal la2Tg; sd2Tg + MO2-vhl standard conditions Fig. 2 from Lim et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated WT + MO1-pdgfrb + MO2-vhl control Fig. 2 from Lim et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated WT + MO1-pdgfrb + MO2-vhl control Fig. 2 from Lim et al., 2017
hematopoietic multipotent progenitor cell decreased amount, ameliorated la2Tg; sd2Tg + MO1-pdgfrb + MO2-vhl standard conditions Fig. 2 from Lim et al., 2017
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.