ZFIN Lab: Sahar Da'as Lab

ZFIN ID: ZDB-LAB-210714-1

Sahar Da'as Lab

PI/Director:	Da'as, Sahar
Contact Person:	Da'as, Sahar
Email:	Zebrafish@sidra.org
URL:
Address:	Sidra Medicinem Al Gharrafa Street Ar-Rayyan, Doha, Qatar
Country:	Qatar
Phone:	+974 40037631
Fax:
Line Designation:	sme

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Hani, Ahmad Research Staff

Hasan, Waseem Research Staff

Abdelrahman, Dou Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Da'as, S.I., Ahmed, I., Hasan, W.H., Abdelrahman, D.A., Aliyev, E., Nisar, S., Bhat, A.A., Joglekar, M.V., Hardikar, A.A., Fakhro, K.A., Akil, A.S.A. (2023) The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature. Journal of translational medicine. 21:171171

Ahmed, I., Ziab, M., Da'as, S., Hasan, W., Jeya, S.P., Aliyev, E., Nisar, S., Bhat, A.A., Fakhro, K.A., Alshabeeb Akil, A.S. (2023) Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Computational and structural biotechnology journal. 21:716730716-730

Elnaggar, M., Al-Mohannadi, A., Hasan, W., Abdelrahman, D., Al-Kubaisi, M.J., Pavlovski, I., Gentlcore, G., Sathappan, A., Kizhakayil, D., Ali, A.I., Mohan, S., Olagunju, D., Cugno, C., Grivel, J.C., Borsotti, C., Follenzi, A., Da'as, S., Deola, S. (2022) CD14+/CD31+ Monocytes Expanded by UM171 Correct Hemophilia A in Zebrafish upon Lentiviral Gene Transfer of Factor VIII. Blood advances. 7(5):697-711

Da'as, S.I., Hasan, W., Salem, R., Younes, N., Abdelrahman, D., Mohamed, I.A., Aldaalis, A., Temanni, R., Mathew, L.S., Lorenz, S., Yacoub, M., Nomikos, M., Nasrallah, G.K., Fakhro, K.A. (2022) Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model. International Journal of Molecular Sciences. 23(16)

Elfatih, A., Da'as, S.I., Abdelrahman, D., Mbarek, H., Mohammed, I., Hasan, W., Fakhro, K.A., Estivill, X., Mifsud, B., Qatar Genome Program Research Consortium (2022) Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP. Human molecular genetics. 31(16):2796-2809

Alkowari, M., Espino-Guarch, M., Daas, S., Abdelrahman, D., Hasan, W., Krishnamoorthy, N., Sathappan, A., Sheehan, P., Panhuys, N.V., The Qatar Genome Program Research Consortium, ., Estivill, X. (2022) Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients. International Journal of Molecular Sciences. 23(6):

Al-Kurbi, A.A., Da'as, S.I., Aamer, W., Krishnamoorthy, N., Poggiolini, I., Abdelrahman, D., Elbashir, N., Al-Shabeeb Akil, A., Glass, G.E., Fakhro, K.A. (2022) A recessive variant in SIM2 in a child with complex craniofacial anomalies and global developmental delay. European Journal of Medical Genetics. 65(4):104455

Al-Jamal, O., Al-Jighefee, H., Younes, N., Abdin, R., Al-Asmakh, M.A., Radwan, A.B., Sliem, M.H., Majdalawieh, A.F., Pintus, G., Yassine, H.M., Abdullah, A.M., Da'as, S.I., Nasrallah, G.K. (2020) Organ-specific toxicity evaluation of stearamidopropyl dimethylamine (SAPDMA) surfactant using zebrafish embryos. The Science of the total environment. 741:140450

Da'as, S.I., Aamer, W., Hasan, W., Al-Maraghi, A., Al-Kurbi, A., Kilani, H., AlRayahi, J., Zamel, K., Stotland, M.A., Fakhro, K.A. (2020) PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development. Cells. 9(8):

Da'as, S.I., Yalcin, H.C., Nasrallah, G.K., Mohamed, I.A., Nomikos, M., Yacoub, M.H., Fakhro, K.A. (2020) Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model. Journal of Cellular Physiology. 235(11):7870-7888

Da'as, S.I., Thanassoulas, A., Calver, B.L., Beck, K., Salem, R., Saleh, A., Kontogianni, I., Al-Maraghi, A., Nasrallah, G.K., Safieh-Garabedian, B., Toft, E., Nounesis, G., Lai, F.A., Nomikos, M. (2019) Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish. Annals of the New York Academy of Sciences. 1448(1):19-29

Nasrallah, G., Salem, R., Da'as, S., Al-Jamal, O.L.A., Scott, M., Mustafa, I. (2019) Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile. Neurotoxicology and teratology. 72:29-38

Zakaria, Z.Z., Benslimane, F.M., Nasrallah, G.K., Shurbaji, S., Younes, N.N., Mraiche, F., Da'as, S.I., Yalcin, H.C. (2018) Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity. BioMed Research International. 2018:1642684

Da'as, S.I., Balci, T.B., Berman, J.N. (2015) Mast cell development and function in the zebrafish. Methods in molecular biology (Clifton, N.J.). 1220:29-57

Balci, T.B., Prykhozhij, S.V., Teh, E.M., Da'as, S.I., McBride, E., Liwski, R., Chute, I.C., Leger, D., Lewis, S.M., Berman, J.N. (2014) A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. British journal of haematology. 167(1):48-61

Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594

Forrester, A.M., Grabher, C., McBride, E.R., Boyd, E.R., Vigerstad, M.H., Edgar, A., Kai, F.B., Da'as, S.I., Payne, E., Look, A.T., and Berman, J.N. (2011) NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis. British journal of haematology. 155(2):167-81

Da'as, S., Teh, E.M., Dobson, J.T., Nasrallah, G.K., McBride, E.R., Wang, H., Neuberg, D.S., Marshall, J.S., Lin, T.J., and Berman, J.N. (2011) Zebrafish mast cells possess an FcepsilonRI-like receptor and participate in innate and adaptive immune responses. Developmental and comparative immunology. 35(1):125-134