ZFIN Lab: Esguerra Lab

ZFIN ID: ZDB-LAB-201202-1

Esguerra Lab

PI/Director:	Esguerra, Camila V.
Contact Person:	Esguerra, Camila V.
Email:	c.v.esguerra@ncmm.uio.no
URL:	https://www.med.uio.no/ncmm/english/people/aca/camilave/index.html
Address:	VISITING ADDRESS Gaustadalléen 21 Forskningsparken 0349 OSLO POSTAL ADDRESS Postboks 1137 Blindern 0318 OSLO
Country:	Norway
Phone:	+47 22840534
Fax:
Line Designation:	uio

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 2 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Banono, Nancy Post-Doc	Shojaeinia, Elham Post-Doc	van der Ent, Wietske Post-Doc
Kirstein-Smardzewska, Karolina Joanna Research Staff	Remiro, Alejandro Pastor Research Staff	Tavara, Ana

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Moussavi, N., van der Ent, W., Diallo, D., Sanogo, R., Malterud, K.E., Esguerra, C.V., Wangensteen, H. (2024) Inhibition of Seizure-Like Paroxysms and Toxicity Effects of Securidaca longepedunculata Extracts and Constituents in Zebrafish Danio rerio. ACS Chemical Neuroscience. 15(3):617-628

Desalegn, A.A., van der Ent, W., Lenters, V., Iszatt, N., Stigum, H., Lyche, J.L., Berg, V., Kirstein-Smardzewska, K.J., Esguerra, C.V., Eggesbø, M. (2023) Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies. Environment International. 181:108271108271

Nieoczym, D., Banono, N.S., Stępnik, K., Kaczor, A.A., Szybkowski, P., Esguerra, C.V., Kukula-Koch, W., Gawel, K. (2023) In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice. International Journal of Molecular Sciences. 24(16):

Doboszewska, U., Socała, K., Pieróg, M., Nieoczym, D., Sawicki, J., Szafarz, M., Gawel, K., Rafało-Ulińska, A., Sajnóg, A., Wyska, E., Esguerra, C.V., Szewczyk, B., Maćkowiak, M., Barałkiewicz, D., Mlyniec, K., Nowak, G., Sowa, I., Wlaź, P. (2023) TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice. Cellular and molecular life sciences : CMLS. 80:133133

Skiba, A., Kozioł, E., Luca, S.V., Budzyńska, B., Podlasz, P., Van Der Ent, W., Shojaeinia, E., Esguerra, C.V., Nour, M., Marcourt, L., Wolfender, J.L., Skalicka-Woźniak, K. (2023) Evaluation of the Antiseizure Activity of Endemic Plant Halfordia kendack Guillaumin and Its Main Constituent, Halfordin, on a Zebrafish Pentylenetetrazole (PTZ)-Induced Seizure Model. International Journal of Molecular Sciences. 24(3):

Silvennoinen, K., Gawel, K., Tsortouktzidis, D., Pitsch, J., Alhusaini, S., van Loo, K.M.J., Picardo, R., Michalak, Z., Pagni, S., Martins Custodio, H., Mills, J., Whelan, C.D., de Zubicaray, G.I., McMahon, K.L., van der Ent, W., Kirstein-Smardzewska, K.J., Tiraboschi, E., Mudge, J.M., Frankish, A., Thom, M., Wright, M.J., Thompson, P.M., Schoch, S., Becker, A.J., Esguerra, C.V., Sisodiya, S.M. (2022) SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility. Acta Neuropathologica. 144(1):107-127

Copmans, D., Kildgaard, S., Roux, E., Partoens, M., Steurs, G., Wang, X., De Borggraeve, W.M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2022) From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin. Pharmaceuticals (Basel, Switzerland). 15(2):

Gawel, K., Kukula-Koch, W., Banono, N.S., Nieoczym, D., Targowska-Duda, K.M., Czernicka, L., Parada-Turska, J., Esguerra, C.V. (2021) 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. International Journal of Molecular Sciences. 22(14):

Banono, N.S., Gawel, K., De Witte, L., Esguerra, C.V. (2020) Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?. Molecular neurobiology. 58(2):877-894

Banono, N.S., Esguerra, C.V. (2020) Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software. Journal of visualized experiments : JoVE. (161):

Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V. (2020) Seizing the moment: Zebrafish epilepsy models. Neuroscience and biobehavioral reviews. 116:1-20

Gawel, K., Kukula-Koch, W., Nieoczym, D., Stepnik, K., Ent, W.V., Banono, N.S., Tarabasz, D., Turski, W.A., Esguerra, C.V. (2020) The Influence of Palmatine Isolated from Berberis sibiricaRadix on Pentylenetetrazole-Induced Seizures in Zebrafish. Cells. 9(5):

Tiraboschi, E., Martina, S., van der Ent, W., Grzyb, K., Gawel, K., Cordero-Maldonado, M.L., Poovathingal, S.K., Heintz, S., Satheesh, S.V., Brattespe, J., Xu, J., Suster, M., Skupin, A., Esguerra, C.V. (2020) New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome. Epilepsia. 61(3):549-560

Gawel, K., Turski, W.A., van der Ent, W., Mathai, B.J., Kirstein-Smardzewska, K.J., Simonsen, A., Esguerra, C.V. (2019) Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene. Molecular neurobiology. 57(4):1904-1916

Copmans, D., Kildgaard, S., Rasmussen, S.A., Ślęzak, M., Dirkx, N., Partoens, M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2019) Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B. Marine drugs. 17(11):

Kamiński, K., Socała, K., Zagaja, M., Andres-Mach, M., Abram, M., Jakubiec, M., Pieróg, M., Nieoczym, D., Rapacz, A., Gawel, K., Esguerra, C.V., Latacz, G., Lubelska, A., Szulczyk, B., Szewczyk, A., Łuszczki, J.J., Wlaź, P. (2019) N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 17(1):309-328

Gawel, K., Banono, N.S., Michalak, A., Esguerra, C.V. (2019) A critical review of zebrafish schizophrenia models: time for validation?. Neuroscience and biobehavioral reviews. 107:6-22

Princely Abudu, Y., Pankiv, S., Mathai, B.J., Håkon Lystad, A., Bindesbøll, C., Brenne, H.B., Yoke Wui Ng, M., Thiede, B., Yamamoto, A., Mutugi Nthiga, T., Lamark, T., Esguerra, C.V., Johansen, T., Simonsen, A. (2019) NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Developmental Cell. 49(4):509-525.e12

Nieoczym, D., Socała, K., Gawel, K., Esguerra, C.V., Wyska, E., Wlaź, P. (2019) Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests. Neurochemical research. 44(5):1043-1055

Aourz, N., Serruys, A.K., Chabwine, J., Balegamire, P.B., Afrikanova, T., Edrada-Ebel, R., Gray, A.I., Kamuhabwa, A.R., Walrave, L., Esguerra, C.V., van Leuven, F., de Witte, P.A.M., Smolders, I., Crawford, A.D. (2018) Identification of GSK-3 as a potential therapeutic entry point for epilepsy. ACS Chemical Neuroscience. 10(4):1992-2003

Franzetti, G.A., Laud-Duval, K., van der Ent, W., Brisac, A., Irondelle, M., Aubert, S., Dirksen, U., Bouvier, C., de Pinieux, G., Snaar-Jagalska, E., Chavrier, P., Delattre, O. (2017) Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene. 36:3505-3514

Tulotta, C., He, S., Chen, L., Groenewoud, A., van der Ent, W., Meijer, A.H., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in molecular biology (Clifton, N.J.). 1451:155-69

Tulotta, C., He, S., van der Ent, W., Chen, L., Groenewoud, A., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model. Advances in experimental medicine and biology. 916:239-63

van der Ent, W., Veneman, W.J., Groenewoud, A., Chen, L., Tulotta, C., Hogendoorn, P.C., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Automation of Technology for Cancer Research. Advances in experimental medicine and biology. 916:315-32

Zhang, Y., Kecskés, A., Copmans, D., Langlois, M., Crawford, A.D., Ceulemans, B., Lagae, L., de Witte, P.A., Esguerra, C.V. (2015) Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine. PLoS One. 10:e0125898

Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285

Leclercq, K., Afrikanova, T., Langlois, M., De Prins, A., Buenafe, O.E., Rospo, C.C., Van Eeckhaut, A., de Witte, P.A., Crawford, A.D., Smolders, I., Esguerra, C.V., Kaminski, R.M. (2015) Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy & behavior : E&B. 45:53-63

van der Ent, W., Burrello, C., de Lange, M.J., van der Velden, P.A., Jochemsen, A.G., Jager, M.J., Snaar-Jagalska, B.E. (2015) Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells. Ocular oncology and pathology. 1:170-81

Schubert, J., Siekierska, A., Langlois, M., May, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J.R., de Kovel, C.G., Thiele, H., Konrad, K., Kawalia, A., Toliat, M.R., Sander, T., Rüschendorf, F., Caliebe, A., Nagel, I., Kohl, B., Kecskés, A., Jacmin, M., Hardies, K., Weckhuysen, S., Riesch, E., Dorn, T., Brilstra, E.H., Baulac, S., Møller, R.S., Hjalgrim, H., Koeleman, B.P., EuroEPINOMICS RES Consortium, Jurkat-Rott, K., Lehman-Horn, F., Roach, J.C., Glusman, G., Hood, L., Galas, D.J., Martin, B., de Witte, P.A., Biskup, S., De Jonghe, P., Helbig, I., Balling, R., Nürnberg, P., Crawford, A.D., Esguerra, C.V., Weber, Y.G., Lerche, H. (2014) Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nature Genetics. 46(12):1327-32

Ban, J., Aryee, D.N., Fourtouna, A., van der Ent, W., Kauer, M., Niedan, S., Machado, I., Rodriguez-Galindo, C., Tirado, O.M., Schwentner, R., Picci, P., Flanagan, A.M., Berg, V., Strauss, S.J., Scotlandi, K., Lawlor, E.R., Snaar-Jagalska, E., Llombart-Bosch, A., Kovar, H. (2014) Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma. Cancer research. 74(22):6578-88

Mommaerts, H., Esguerra, C.V., Hartmann, U., Luyten, F.P., Tylzanowski, P. (2014) Smoc2 modulates embryonic myelopoiesis during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(11):1375-90

Challal, S., Buenafe, O.E., Queiroz, E.F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F.M., Harvey, A.L., Lerche, H., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., Crawford, A.D. (2014) Zebrafish-bioassay guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ACS Chemical Neuroscience. 5(10):993-1004

Spincemaille, P., Pham, D.H., Chandhok, G., Verbeek, J., Zibert, A., Libbrecht, L., Schmidt, H., Esguerra, C.V., de Witte, P.A., Cammue, B.P., Cassiman, D., Thevissen, K. (2014) The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease. Toxicology and applied pharmacology. 280(2):345-51

van der Ent, W., Burrello, C., Teunisse, A.F., Ksander, B.R., Van der Velden, P.A., Jager, M.J., Jochemsen, A.G., Snaar-Jagalska, B.E. (2014) Modelling of human uveal melanoma in Zebrafish xenograft embryos. Investigative ophthalmology & visual science. 55(10):6612-22

van der Ent, W., Jochemsen, A.G., Teunisse, A.F., Krens, S.G., Szuhai, K., Spaink, H.P., Hogendoorn, P.C., Snaar-Jagalska, B.E. (2014) Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. The Journal of pathology. 233(4):415-24

Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559

Orellana-Paucar, A.M., Afrikanova, T., Thomas, J., Aibuldinov, Y.K., Dehaen, W., de Witte, P.A., and Esguerra, C.V. (2013) Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One. 8(12):e81634

Gebruers, E., Cordero-Maldonado, M.L., Gray, A.I., Clements, C., Harvey, A.L., Edrada-Ebel, R., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling. PLoS One. 8(12):e83293

Buenafe, O.E., Orellana Paucar, A.M., Maes, J., Huang, H., De Borggraeve, W.M., Crawford, A.D., Luyten, W., Esguerra, C.V., and de Witte, P. (2013) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chemical Neuroscience. 4(11):1479-87

Suls, A., Jaehn, J.A., Kecskés, A., Weber, Y., Weckhuysen, S., Craiu, D.C., Siekierska, A., Djémié, T., Afrikanova, T., Gormley, P., von Spiczak, S., Kluger, G., Iliescu, C.M., Talvik, T., Talvik, I., Meral, C., Caglayan, H.S., Giraldez, B.G., Serratosa, J., Lemke, J.R., Hoffman-Zacharska, D., Szczepanik, E., Barisic, N., Komarek, V., Hjalgrim, H., Møller, R.S., Linnankivi, T., Dimova, P., Striano, P., Zara, F., Marini, C., Guerrini, R., Depienne, C., Baulac, S., Kuhlenbäumer, G., Crawford, A.D., Lehesjoki, A.E., de Witte, P.A., Palotie, A., Lerche, H., Esguerra, C.V., De Jonghe, P., and Helbig, I. (2013) De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome. American journal of human genetics. 93(5):967-975

Cordero-Maldonado, M.L., Siverio-Mota, D., Vicet-Muro, L., Wilches-Arizábala, I.M., Esguerra, C.V., de Witte, P.A., and Crawford, A.D. (2013) Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites. PLoS One. 8(10):e75404

Spaink, H.P., Cui, C., Wiweger, M.I., Jansen, H.J., Veneman, W.J., Marín-Juez, R., de Sonneville, J., Ordas, A., Torraca, V., van der Ent, W., Leenders, W.P., Meijer, A.H., Snaar-Jagalska, B.E., and Dirks, R.P. (2013) Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods (San Diego, Calif.). 62(3):246-54

Lauinger, I.L., Vivas, L., Perozzo, R., Stairiker, C., Tarun, A., Zloh, M., Zhang, X., Xu, H., Tonge, P.J., Franzblau, S.G., Pham, D.H., Esguerra, C.V., Crawford, A.D., Maes, L., and Tasdemir, D. (2013) Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target. Journal of natural products. 76(6):1064-1070

Bohni, N., Cordero-Maldonado, M.L., Maes, J., Siverio-Mota, D., Marcourt, L., Munck, S., Kamuhabwa, A.R., Moshi, M.J., Esguerra, C.V., de Witte, P.A., Crawford, A.D., and Wolfender, J.L. (2013) Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products. PLoS One. 8(5):e64006

Afrikanova, T., Serruys, A.S., Buenafe, O.E., Clinckers, R., Smolders, I., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs. PLoS One. 8(1):e54166

Orellana-Paucar, A.M., Serruys, A.S., Afrikanova, T., Maes, J., De Borggraeve, W., Alen, J., León-Tamariz, F., Wilches-Arizábala, I.M., Crawford, A.D., de Witte, P.A., and Esguerra, C.V. (2012) Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 24(1):14-22

Challal, S., Bohni, N., Buenafe, O.E., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., and Crawford, A.D. (2012) Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products. Chimia. 66(4):229-232

Ghotra, V.P., He, S., de Bont, H., van der Ent, W., Spaink, H.P., van de Water, B., Snaar-Jagalska, B.E., and Danen, E.H. (2012) Automated whole animal bio-imaging assay for human cancer dissemination. PLoS One. 7(2):e31281

Maes, J., Verlooy, L., Buenafe, O.E., de Witte, P.A., Esguerra, C.V., and Crawford, A.D. (2012) Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae. PLoS One. 7(10):e43850

Vermoesen, K., Serruys, A.S., Loyens, E., Afrikanova, T., Massie, A., Schallier, A., Michotte, Y., Crawford, A.D., Esguerra, C.V., de Witte, P.A., Smolders, I., and Clinckers, R. (2011) Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 22(3):450-60

Crawford, A.D., Liekens, S., Kamuhabwa, A.R., Maes, J., Munck, S., Busson, R., Rozenski, J., Esguerra, C.V., and de Witte, P.A. (2011) Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East african medicinal plants. PLoS One. 6(2):e14694

Crawford, A.D., Esguerra, C.V., and de Witte, P.A. (2008) Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. Planta Medica. 74(6):624-632

Esguerra, C.V., Nelles, L., Vermeire, L., Ibrahimi, A., Crawford, A.D., Derua, R., Janssens, E., Waelkens, E., Carmeliet, P., Collen, D., and Huylebroeck, D. (2007) Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development (Cambridge, England). 134(24):4381-4393

Yoda, H., Momoi, A., Esguerra, C.V., Meyer, D., Driever, W., Kondoh, H., and Furutani-Seiki, M. (2003) An expression pattern screen for genes involved in the induction of the posterior nervous system of zebrafish. Differentiation; research in biological diversity. 71(2):152-162

Stalmans, I., Lambrechts, D., De Smet, F., Jansen, S., Wang, J., Maity, S., Kneer, P., von der Ohe, M., Swillen, A., Maes, C., Gewillig, M., Molin, D.G., Hellings, P., Boetel, T., Haardt, M., Compernolle, V., Derwerchin, M., Plaisance, S., Vlietinck, R., Emanuel, B., Gittenberger-de Groot, A.C., Scambler, P., Morrow, B., Driscol, D.A., Moons, L., Esguerra, C.V., Carmeliet, G., Behn-Krappa, A., Devriendt, K., Collen, D., Conway, S.J., and Carmeliet, P. (2003) VEGF: a modifier of the del22q11 (DiGeorge) syndrome?. Nature medicine. 9(2):173-182

Doitsidou, M., Reichman-Fried, M., Stebler, J., Köprunner, M., Dörries, J., Meyer, D., Esguerra, C.V., Leung, T., and Raz, E. (2002) Guidance of primordial germ cell migration by the chemokine SDF-1. Cell. 111(5):647-659