ZFIN ID: ZDB-LAB-060201-1
Duan Lab
PI/Director: Duan, Cunming
Contact Person: Duan, Cunming
Email: cduan@umich.edu
URL: http://www.biology.lsa.umich.edu/research/labs/cduan/
Address: Department of Molecular, Cellular and Developmental Biology The University of Michigan 3065 Natural Science Building 830 North University Street Ann Arbor, MI 48109-1048 USA
Country: United States
Phone: (734) 763-4710
Fax:
Line Designation: mi


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Liu, C., Dai, W., Bai, Y., Chi, C., Xin, Y., He, G., Mai, K., Duan, C. (2017) Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action. Scientific Reports. 7:1994
Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
Zhang, P., Bai, Y., Lu, L., Li, Y., Duan, C. (2016) An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex. eLIFE. 5
Fukushima, T., Yoshihara, H., Furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S.I., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., Takahashi, S.I. (2015) Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. Nature communications. 6:6780
Rong, X., Chen, C., Zhou, P., Zhou, Y., Li, Y., Lu, L., Liu, Y., Zhou, J., Duan, C. (2014) R-Spondin 3 Regulates Dorsoventral and Anteroposterior Patterning by Antagonizing Wnt/β-Catenin Signaling in Zebrafish Embryos. PLoS One. 9(6):e99514
Zhang, P., Yao, Q., Lu, L., Li, Y., Chen, P.J., Duan, C. (2014) Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Reports. 6:1110-21
Liu, C., Luan, J., Bai, Y., Li, Y., Lu, L., Liu, Y., Hakuno, F., Takahashi, S., Duan, C., and Zhou, J. (2014) Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos. Gen. Comp. Endocrinol.. 197:82-91
Dai, W., Bai, Y., Hebda, L., Zhong, X., Liu, J., Kao, J., and Duan, C. (2013) Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell death and differentiation. 21(4):568-81
Zhou, J., Xiang, J., Zhang, S., and Duan, C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology. 154(10):3753-63
Huang, Y., Harrison, M.R., Osorio, A., Kim, J., Baugh, A., Duan, C., Sucov, H.M., and Lien, C.L. (2013) Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One. 8(6):e67266
Rytkönen, K.T., Akbarzadeh, A., Miandare, H.K., Kamei, H., Duan, C., Leder, E.H., Williams, T.A., and Nikinmaa, M. (2013) SUBFUNCTIONALIZATION OF CYPRINID HYPOXIA-INDUCIBLE FACTORS FOR ROLES IN DEVELOPMENT AND OXYGEN SENSING. Evolution. 67(3):873-882
Kjaer-Sorensen, K., Engholm, D.H., Kamei, H., Morch, M.G., Kristensen, A.O., Zhou, J., Conover, C.A., Duan, C., and Oxvig, C. (2013) Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. The Journal of biological chemistry. 288(14):9982-92
Jiao, S., Ren, H., Li, Y., Zhou, J., Duan, C., Lu, L. (2013) Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells.. Molecular and cellular biochemistry. 373(1):107-113
Feng, Q., Zou, X., Lu, L., Li, Y., Liu, Y., Zhou, J., and Duan, C. (2012) The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/beta-catenin Activity in Zebrafish. PLoS One. 7(12):e52674
Zhang, P., Lu, L., Yao, Q., Li, Y., Zhou, J., Liu, Y., and Duan, C. (2012) Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3alpha. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 303(11):R1165-1174
Onuma, T.A., and Duan, C. (2012) Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(7):2941-2950
Onuma, T.A., Ding, Y., Abraham, E., Zohar, Y., Ando, H., and Duan, C. (2011) Regulation of Temporal and Spatial Organization of Newborn GnRH Neurons by IGF Signaling in Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(33):11814-11824
Daza, D.O., Sundström, G., Bergqvist, C.A., Duan, C., and Larhammar, D. (2011) Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology. 152(6):2278-2289
Zhang, C., Lu, L., Li, Y., Wang, X., Zhou, J., Liu, Y., Fu, P., Gallicchio, M.A., Bach, L.A., and Duan, C. (2011) IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. International Journal of Cancer. 30(9):2003-2012
Zhong, Y., Lu, L., Zhou, J., Li, Y., Liu, Y., Clemmons, D.R., and Duan, C. (2011) IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. Journal of Cell Science. 124(11):1925-1935
Jiao, S., Dai, W., Lu, L., Liu, Y., Zhou, J., Li, Y., Korzh, V., and Duan, C. (2011) The Conserved Clusterin Gene Is Expressed in the Developing Choroid Plexus Under the Regulation of Notch But Not IGF Signaling in Zebrafish. Endocrinology. 152(5):1860-1871
Kamei, H., Ding, Y., Kajimura, S., Wells, M., Chiang, P., and Duan, C. (2011) Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development (Cambridge, England). 138(4):777-786
Dai, W., Kamei, H., Zhao, Y., Ding, J., Du, Z., and Duan, C. (2010) Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(6):2020-2029
Zou, S., Kamei, H., Modi, Z., and Duan, C. (2009) Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development. PLoS One. 4(9):e7026
Bansal, T., Lenhart, J., Kim, T., Duan, C., and Maharbiz, M.M. (2009) Patterned delivery and expression of gene constructs into zebrafish embryos using microfabricated interfaces. Biomedical Microdevices. 11(3):633-641
Wang, X., Lu, L., Li, Y., Li, M., Chen, C., Feng, Q., Zhang, C., and Duan, C. (2009) Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 296(5):R1348-R1357
Li, M., Li, Y., Lu, L., Wang, X., Gong, Q., and Duan, C. (2009) Structural, gene expression, and functional analysis of the Fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 296(3):R588-R566
Zhou, J., Li, W., Kamei, H., and Duan, C. (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One. 3(12):e3926
Toyoshima, Y., Monson, C., Duan, C., Wu, Y., Gao, C., Yakar, S., Sadler, K.C., and Leroith, D. (2008) The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology. 149(12):5996-6005
Kamei, H., Lu, L., Jiao, S., Li, Y., Gyrup, C., Laursen, L.S., Oxvig, C., Zhou, J., and Duan, C. (2008) Duplication and Diversification of the Hypoxia-Inducible IGFBP-1 Gene in Zebrafish. PLoS One. 3(8):e3091
Schlueter, P.J., Peng, G., Westerfield, M., and Duan, C. (2007) Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression. Cell death and differentiation. 14(6):1095-1105
Schlueter, P.J., Sang, X., Duan, C., and Wood, A.W. (2007) Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival. Developmental Biology. 305(1):377-387
Schlueter, P.J., Royer, T., Farah, M.H., Laser, B., Chan, S.J., Steiner, D.F., and Duan, C. (2006) Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(8):1230-1232
Kajimura, S., Aida, K., and Duan, C. (2006) Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression. Molecular and cellular biology. 26 (3):1142-1155
Wood, A.W., Schlueter, P.J., and Duan, C. (2005) Targeted knockdown of insulin-like growth factor binding protein-2 (IGFBP-2) disrupts cardiovascular development in zebrafish embryos. Molecular endocrinology (Baltimore, Md.). 19(4):1024-1034
Li, Y., Xiang, J., and Duan, C. (2005) Insulin-like growth factor binding protein-3 (IGFBP-3) plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation. The Journal of biological chemistry. 280(5):3613-3620
Kajimura, S., Aida, K., and Duan, C. (2005) Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc. Natl. Acad. Sci. USA. 102(4):1240-1245
Wood, A.W., Duan, C., and Bern, H.A. (2005) Insulin-Like Growth Factor Signaling in Fish. International review of cytology. 243:215-285
Duan, C., Ding, J., Schlueter, P.J., Li, Y., Zhang J., and Royer, T. (2003) A zebrafish view of the insulin-like growth factor signaling pathway. Dong wu xue bao. [Acta zoologica Sinica]. 49:421-431
Maures, T.J. and Duan, C. (2002) Structure, developmental expression, and physiological regulation of zebrafish IGF binding protein-1. Endocrinology. 143(7):2722-2731
Maures, T., Chan, S.-J., Xu, B., Sun, H., Ding, J., and Duan, C. (2002) Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I receptors and their ligands in zebrafish. Endocrinology. 143(5):1858-1871
Duan, C. (2002) Regulation of insulin-like growth factor (IGF) actions by IGF binding protein in zebrafish. Fisheries science : FS. 68:765-768
Pozios, K.C., Ding, J., Degger, B., Upton, Z., and Duan, C. (2001) IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 280(4):R1230-R1239
Maures, T. and Duan, C. (2000) Expression of insulin-like growth factor binding protein-1 in zebrafish. American zoologist. 40(6):1120
Duan, C.M., Ding, J., Li, Q., Tsai, W., and Pozios, K. (1999) Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish. Proc. Natl. Acad. Sci. USA. 96(26):15274-15279