Figure 4

Figure 4

Summary of Primary Screening Results. Table depicting effects on th expression observed in zebrafish embryos after treatments with inhibitors shown at left. Only when treatment with at least one compound concentration caused one third or more of the assayed embryos to be affected, th expression was classified as decreased or increased, respectively. Treatments at 1 to 30 µM were considered, while 100 µM was excluded due to high lethality with most compounds. Color code at bottom: decreased or increased th expression represents both potentially changed expression levels or changed number of expressing cells, which could not be distinguished during qualitative analysis of images. (*) For Namoline, the increase of DC4/5/6 was only observed at 10 µM. (**) For PU139, only 7 out of 23 embryos showed a slight increase in stain intensity.