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Fig. 1
Cardiac injury models. Illustration of myocardial infarction (MI), resection, cryoinjury and genetic ablation of cardiomyocytes (CMs). MI is induced by surgically ligating the left anterior descending coronary artery, leading to tissue death downstream of the ligature. Resection is used to remove part of the ventricle. Cryoinjury is used to cauterize part of the ventricle with a cryoprobe. Genetic ablation is achieved by driving CM-specific Nitroreductase (NTR) expression, which in turn converts a prodrug into a cytotoxic product leading to CM death; alternatively, CM-specific expression of the Diphtheria toxin receptor (DTR) will render the CMs susceptible to diphtheria toxin (DT)-induced cell death