ZFIN Image: Wang et al., 2018, Fig. 4

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Fig. 4

Triptolide suppressed podocyte apoptosis. (A) 84 hpf larvae treated with MTZ for 24 h exhibit remarkable podocyte apoptosis signalling compared to the untreated group (CTL) on immunostains against cleaved caspase-3. The number of apoptotic cells was significantly reduced in the triptolide treatment group. (B) Quantification of caspase-3-stained area (green) to mCherry (red). Data are expressed as the means ± SEM. The confocal images are shown at a maximum intensity projection. (n = 3), **P < 0.01; *P < 0.05. (Original magnification, x1000). (C) Annexin V-FITC/PI staining followed by FCM showed podocytes apoptosis induced by PAN was alleviated by triptolide. **P < 0.01. (On the basis of three triplicate tests).

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Acknowledgments

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