ZFIN Image: Xiao et al., 2016, Fig. S5

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Figure Caption

Fig. S5

Inhibition of Brg1 causes permanent defects in heart regeneration. Six wild-type (wt) sibling hearts (a-b) and 5 dn-xBrg1 transgenic (tg) hearts (c-d) at 60 dpa (heat shock treatment only from 5dpa to 30dpa) were subjected to serial sections, and half of sections were then used for AFOG staining (a, c) and half for MF20 immunofluorescence staining (b, d). Higher-magnification images of areas in squares were shown in the right side of panels a and c. Note that 3 of 5 tg hearts had fibrosis and compromised myocardial regeneration even although they had no heat-induced dn-xBrg1 proteins from 30 to 60 dpa. Arrowheads indicate fibrosis. Scale bars, 100 μm.

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