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Fig. S6
Effects of 12 - 32 hpf Cpd3 exposure on pancreas, liver, and hepatopancreas progenitor development. A) Cpd3 treatment from 12 - 32 hpf reduces the size of the exocrine pancreas in Tg(elastase:eGFP) embryos at 72 hpf. B) Cpd3 treatment from 12 - 32 hpf does not impact the size of the prox1, hnf4α, and pdx1 liver and pancreas progenitor populations. C) Cpd3 treatment from 12 - 32 hpf does not increase the size of the liver bud (red arrow) by confocal imaging of Tg(sox17:eGFP) embryos.
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Reprinted from Developmental Biology, 418(1), Nissim, S., Weeksb, O., Talbot, J.C., Hedgepeth, J.W., Wucherpfennig, J., Schatzman-Bone, S., Swinburne, I., Cortes, M., Alexa, K., Megason, S., North, T.E., Amacher, S.L., Goessling, W., Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development, 108-23, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.