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Fig. S7
Overexpression of vegfc induces ectopic branching of intestinal vasculature in flt4 mutants. Confocal microscope images of Tg(kdrl:mCherry) embryos. 60 minute heat shock induction of vegfc in Tg(hsp70:vegfc) embryos at 32 hpf results in hyperbranching and ectopic sprouting from the SIV (B,D) indicated by arrows, compared to control non-heat shocked embryos (A,C) at 52 hpf. Embryos were individually genotyped for flt4 mutation after imaging.
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Reprinted from Developmental Biology, 411(1), Koenig, A.L., Baltrunaite, K., Bower, N.I., Rossi, A., Stainier, D.Y., Hogan, B.M., Sumanas, S., Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein, 115-27, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.