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Fig. S3
Fig. S3. Live embryo analysis of sfrp1a/sfrp5 depletion during retinal morphogenesis. Time lapse live confocal imaging of the Tg(Olrx3:GFP) line was employed to visualize retinal morphogenesis. Images are maximum projections of 30 slices collected every 3 μm at 10 minute intervals. Compared to WT, sfrp1a/5 morpholino injected embryos display thinning of the ventral retina as development proceeds post-24 hpf (frames 26 hpf to 39 hpf). Thinning retinal tissue is indicated with a yellow asterisk.
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Reprinted from Developmental Biology, 388(2), Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J., Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development, 192-204, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.