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Fig. 2
Characterization. Of liposomal SANT75 in Shh-light2 cell and transgenic zebrafish assays.
(A) Inhibition of Hh activation by liposomal SANT75 and free SANT75 in SHh-light2 cells. IC50s for both are approximately 5 nM. (B) Inhibition of Hh activity in vivo by liposomal SANT75 and free SANT75 using Gli-GFP reporter in transgenic zebrafish embryos. (C) Inhibition of inter-segmental blood vessel by liposomal SANT75 and free SANT75 in Flk-GFP transgenic zebrafish embryos.
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