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Fig. 8

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ZDB-IMAGE-120601-65
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Figures for van der Velden et al., 2012
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Fig. 8 Restoration of mesenchymal gene expression and fin bud outgrowth in apc/ring1b mutants. (A-X) Dorsal views of embryos of the indicated genotypes stained for tbx5, fgf24 and fgf10 at 32 hpf (A-L) and 72 hpf (M-X). tbx5 (B,N), fgf24 (F,R) and fgf10 (J,V) are overexpressed in the apc pectoral fin mesenchyme at both 32 and 72 hpf. Expression of fgf24 (H) and fgf10 (L) is increased in apc/ring1b mutants compared with ring1b mutants (G,K) at 32 hpf. Expression of tbx5 (P), fgf24 (T) and fgf10 (X) is maintained in apc/ring1b mutants at 72 hpf. Arrowheads indicate staining at the fin bud region. (Y-BB) Lateral views of 72 hpf embryos of the indicated genotypes at the level of the pectoral fin. A rudimentary fin bud (outlined) is formed in apc/ring1b mutants at 72 hpf (BB).

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