ZFIN Image: Dal-Pra et al., 2011, Fig. S2

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Figure Caption

Fig. S2 FoxA1 loss of function strongly amplifies FoxA2–FoxA3 phenotype. (A) foxA1 expression is initiated at tail bud stage in axial mesoderm. (B and C) FoxA1 morphant presents normal axial structures at 24 hpf. (D and G) Loss of FoxA1 alone has no effect on axial structures development but (F and I) strongly increases the strength of FoxA2 and FoxA3 shown in (E and H). Triple FoxA1-FoxA2–FoxA3 morphants lack all axial structures. While col2a1a and im:7144261 expressions are normal in FoxA1 morphants (D and G), they are completely absent in triple FoxA1-FoxA2–FoxA3 morphants (F and I; 98% n = 55 for im:7144261). (A) Dorsal views, anterior up. (B–I) Lateral views, anterior to the left.

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Acknowledgments

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Reprinted from Developmental Biology, 350(2), Dal-Pra, S., Thisse, C., and Thisse, B., FoxA transcription factors are essential for the development of dorsal axial structures, 484-495, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.