IMAGE

Fig. 3

ID
ZDB-IMAGE-100319-15
Source
Figures for Ko et al., 2010
Image
Figure Caption

Fig. 3 Patterning in bromi,Gli3xt and bromi,Gli2 Double Mutants
(A) FoxA2, Nkx2.2, and HB9 immunostaining of E10.5 WT, bromi, Gli3xt, and bromi,Gli3xt double-mutant spinal neural tubes. Expression of these markers was normal in Gli3xt mutants, but disruption of Gli3 restored floor plate specification in bromi,Gli3xt double mutants.
(B) FoxA2, Nkx2.2, and HB9 immunostaining of E10.5 WT, bromi, Gli2, and bromi,Gli2 double-mutant spinal neural tubes. Ventral neural patterning is similar in bromi and Gli2 single mutants. bromi,Gli2 double-mutant neural tubes lacked Nkx2.2+ cells, whereas they were always detected, albeit in reduced numbers, in either single mutant.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 18(2), Ko, H.W., Norman, R.X., Tran, J., Fuller, K.P., Fukuda, M., and Eggenschwiler, J.T., Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction, 237-247, Copyright (2010) with permission from Elsevier. Full text @ Dev. Cell