ZFIN Image: Rieger et al., 2009, Fig. 11

Image

Figure Caption

Fig. 11 Impaired terminal differentiation of migrating Cadherin-2 deficient GCs.

(A–F) Dorsal views of WT (A, C, E) and pac^-/-R cerebella (B, D, F). ISH for the granule cell differentiation markers neuroD (A, B, 3dpf), vglut1 (C, D, 4dpf), and gabαRa6 (E, F, 6dpf). NeuroD expression in pac^-/-R cerebella appears scattered, likely resulting from randomly migrating GCs. However, the strength of expression is similar to WT. Vglut1 expression is strongly reduced in pac^-/-R and expression of the terminal granule cell differentiation marker gabaR_Aα6 is almost absent in pac^-/-R cerebella (black arrows depict residual patches of expression in ventro-lateral cerebellar regions). cb, cerebellum; ot, optic tectum.

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