ZFIN Image: Marlow et al., 1998, Fig. 4

Image

Figure Caption

Fig. 4 Abnormal expression of shh gene at 30 hpf is correlated with the cyclopia phenotype in tri^m209 and kny^m119 tri^m209 mutant embryos. (A–D) Lateral views. shh expression in wild-type (A) and kny^m119 mutants (B) extends to the anterior tip of the embryo. In contrast, the shh expression domain is compressed along the AP axis and fails to extend to the anterior tip of the embryo in cyclopic tri^m209 (C) and kny^m119 tri^m209 (D) mutants. The telencephalon occupies a more dorsal location in tri^m209 (C) and kny^m119 tri^m209 (D) embryos than observed for wild-type embryos (A). (E–H) Dorsal views. shh expression in the hypothalamus is compressed and positioned more posteriorly in tri^m209 (G) and kny^m119 tri^m209 (H) mutant embryos compared to wild-type (E) and kny^m119 (F) embryos. Arrows, middiencephalic boundary; mb, midbrain; ey, eye; hb, hindbrain; fb, forebrain; fp, floor plate expression in the spinal cord.

Acknowledgments

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Reprinted from Developmental Biology, volume 203, Marlow, F., Zwartkruis, F., Malicki, J., Neuhauss, S.C.F., Abbas, L., Weaver, M., Driever, W., and Solnica-Krezel, L., Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish, 382-399, Copyright 1998, with permission from Elsevier.

Reprinted from Developmental Biology, 203, Marlow, F., Zwartkruis, F., Malicki, J., Neuhauss, S.C.F., Abbas, L., Weaver, M., Driever, W., and Solnica-Krezel, L., Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish, 382-399, Copyright (1998) with permission from Elsevier. Full text @ Dev. Biol.