Gene

tbx2b

ID
ZDB-GENE-990726-27
Name
T-box transcription factor 2b
Symbol
tbx2b Nomenclature History
Previous Names
  • tbx-c
  • tbx2
  • tbxc
  • fby
  • hm:zeh1581 (1)
  • lor
  • zeh1581
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cell migration involved in gastrulation; and photoreceptor cell fate specification. Predicted to localize to nuclear chromatin. Is expressed in several structures, including heart; immature eye; mesoderm; nervous system; and pronephros. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2).
Genome Resources
Note
None
Expression
All Expression Data
86 figures from 60 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
35 figures from 20 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vertebral anomalies and variable endocrine and T-cell dysfunction Alliance Vertebral anomalies and variable endocrine and T-cell dysfunction 618223
Associated With tbx2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR022582 Transcription factor, T-box, region of unknown function
Family IPR001699 Transcription factor, T-box
Family IPR002070 Transcription factor, Brachyury
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, Brachyury Transcription factor, T-box Transcription factor, T-box, conserved site Transcription factor, T-box, region of unknown function
UniProtKB:Q7ZTU9 687
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations