ZFIN ID: ZDB-GENE-010110-2
Gene Name: TAP binding protein (tapasin), tandem duplicate 1
Gene Symbol: tapbp.1    Nomenclature History

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Previous Names: tapbp (1), tpsn, zgc:109814

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be involved in antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to localize to membrane. Is expressed in primordial germ cell. Human ortholog(s) of this gene implicated in MHC class I deficiency and severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000079402 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [MGC:109814]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020938Tg Transgenic Insertion Unknown Unknown DNA
sa36774 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tapbp.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    MHC class I deficiency Alliance Bare lymphocyte syndrome, type I 604571
    DISEASE ASSOCIATED WITH tapbp.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process antigen processing and presentation of endogenous peptide antigen via MHC class I (more)
    Cellular Component membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tapbp.1-001 (1) 1737
    tapbp.1-201 (1)    Ensembl 1715
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tapbp.1 No data available
    MARKER RELATIONSHIPS
    tapbp.1 Contained in: [BAC] CH73-213J4 (1), DKEY-264N13 (1) (order this)
    [PAC] BUSM1-179B20 (1)
    tapbp.1 Encodes: [cDNA] cssl:d105 (1), MGC:109814 (1), MGC:171979 (1), MGC:192901 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:BC152022 (1) 1702 nt
    Genomic GenBank:BX927188 163213 nt
    Select Tool
    Polypeptide UniProtKB:A7MC30 (1) 443 aa
    Sequence Information (all 18)
    ORTHOLOGY for tapbp.1 ( Chr: 19 )
    CITATIONS (36)