ZFIN ID: ZDB-GENE-990415-277
Gene Name: forkhead box N4
Gene Symbol: foxn4    Nomenclature History

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Previous Names: whn, sli, slipjig, whna (1), winged helix nude

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in heart development; positive regulation of transcription, DNA-templated; and regulation of heart contraction. Predicted to localize to nucleus. Is expressed in several structures, including forebrain neural keel; nervous system; optic vesicle; pericardial region; and presumptive neural retina. Orthologous to human FOXN4 (forkhead box N4).
Genome Resources: Alliance (1),  Gene:30315 (1),  Ensembl(GRCz11):ENSDARG00000010591 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s644 Insertion Unknown Frameshift, Premature Stop ENU
sa33562 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm117c Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-foxn4 N/A 1
    MO2-foxn4 N/A 1
    MO3-foxn4 N/A 1
    DISEASE ASSOCIATED WITH foxn4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH foxn4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxn4-201 (1)    Ensembl 2752
    ncRNA foxn4-002 (1)    Ensembl 614
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS
    Addgene:foxn4
    CONSTRUCTS WITH SEQUENCES FROM foxn4 No data available
    MARKER RELATIONSHIPS
    foxn4 Contained in: [BAC] CH211-250O15 (1), DKEY-189P24 (1) (order this)
    foxn4 Encodes: [cDNA] MGC:158202 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131099 (1) 2762 nt
    Genomic GenBank:BX510366 (1) 179350 nt
    Select Tool
    Polypeptide UniProtKB:A2BGM5 (1) 550 aa
    Sequence Information (all 28)
    ORTHOLOGY for foxn4 ( Chr: 5 )
    CITATIONS (45)