Gene

tpma

ID

ZDB-GENE-990415-269

Name

alpha-tropomyosin

Symbol

tpma Nomenclature History

Previous Names

tm
fb37a09
TPM1-2 alpha (1)
tropomyosin alpha chain
wu:fb37a09 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in myeloid cell development. Predicted to localize to actin filament. Is expressed in adaxial cell; male organism; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion; dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 1. Orthologous to several human genes including TPM1 (tropomyosin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

37 figures from 26 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77897 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Gieger et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpma Human Ortholog

No data available

Associated With tpma Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin

Domain Details Per Protein

Protein	Length	Tropomyosin
UniProtKB:A0A1D5NSG1 InterPro	134
UniProtKB:A0A1D5NSX9 InterPro	209
UniProtKB:Q5SPK5 InterPro	248
UniProtKB:A0A1D5NSL6 InterPro	162
UniProtKB:A0A1D5NS40 InterPro	178
UniProtKB:A0A1D5NSE7 InterPro	171
UniProtKB:A0A1D5NSY1 InterPro	135
UniProtKB:A0A1L6UW60 InterPro	188
UniProtKB:A0A1D5NSG3 InterPro	171
UniProtKB:A0A1I7Q3W7 InterPro	205
UniProtKB:Q5SPK6 InterPro	284
UniProtKB:P13104 InterPro	284
UniProtKB:A0A1D5NSA5 InterPro	221

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tpma-001 (1)	1618 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-002 (1)	1407 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-201 (1) Ensembl	812 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-202 (1) Ensembl	3089 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-203 (1) Ensembl	529 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-204 (1) Ensembl	721 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-205 (1) Ensembl	487 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-206 (1) Ensembl	402 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-207 (1) Ensembl	631 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-208 (1) Ensembl	751 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-209 (1) Ensembl	753 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-210 (1) Ensembl	639 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations