Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-208
Gene Name: platelet derived growth factor receptor alpha
Gene Symbol: pdgfra
Previous Names: pdgfr-a (1), etID309717.20 (1), wu:fc27f02, wu:fv91b12
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 7 publications
Directly Submitted Expression Data: 6 figures (32 images) from Thisse et al., 2008 [cssl:d115]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  choroidal fissure, cranial neural crest, cranial neural crest cell, head (all 24) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 6 genotypes
Alleles: b1059, la021462Tg
Knockdown reagents: MO1-pdgfra (1), MO2-pdgfra (1)
PHENOTYPE
Data: 4 figures from 2 publications
Observed in: cranial vasculature, cranium, ethmoid cartilage, lip (all 7) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Gastrointestinal stromal tumor, somatic 606764
Hypereosinophilic syndrome, idiopathic, resistant to imatinib 607685
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic cranial skeleton morphogenesis (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016243 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027290 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdgfra-002 (1) 6274
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    ab1-PDGFRA (1)
    CONSTRUCTS WITH SEQUENCES FROM pdgfra No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdgfra Contained in: [BAC] CH211-176L11 (1) (order this), DKEY-97C6 (1)
    pdgfra Encodes: [EST] fc27f02, fv91b12
    [cDNA] cssl:d115 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131459 (1) 3788 bp
    Genomic RefSeq:NW_003335834 (1) 47308 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RID4 (1) 1101 aa
    Sequence Clusters UniGene:75077 (1)
    Sequence Information (all 30)
    OTHER pdgfra GENE PAGES
  • Gene:386856 (1)
  • VEGA:OTTDARG00000033821 (1)
  • MAPPING INFORMATION
    Chr: 20, 4 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish pdgfra 20, 4  
    Human PDGFRA 4 (4q12)
  • OMIM:173490
  • Gene:5156
  • Mouse Pdgfra 5 ( 39.55 cM)
  • MGI:97530
  • Gene:18595
  • CITATIONS (35)