ZFIN ID: ZDB-GENE-990415-208
Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol: pdgfra
Sequence Ontology ID : SO:0000704

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Previous Names: pdgfr-a (1), etID309717.20 (1), wu:fc27f02, wu:fv91b12

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 20 figures from 11 publications
Directly Submitted Expression Data: 6 figures (32 images) from Thisse et al., 2008 [cssl:d115]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior lateral plate mesoderm, choroidal fissure, cranial blood vessel (all 29) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1059 Point Mutation Unknown Missense ENU
la021462Tg Transgenic Insertion Unknown Unknown DNA
sa271 Point Mutation Unknown Premature Stop ENU
sa29348 Point Mutation Unknown Premature Stop ENU
sa43427 Point Mutation Unknown Premature Stop ENU
sa43428 Point Mutation Unknown Premature Stop ENU
sk16 Point Mutation Intron 15 Splice Site, Exon Loss of Exon 14, Frameshift, Premature Stop ENU
Targeting reagents: MO1-pdgfra (1), MO2-pdgfra (1), MO3-pdgfra (1)
PHENOTYPE
Data: 11 figures from 4 publications
Observed in: anatomical structure, anterior lateral plate mesoderm, cardiac muscle cell, cardiac muscle progenitor cell migration to the midline involved in heart field formation (all 19) expand
DISEASE ASSOCIATED WITH pdgfra HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
gastrointestinal stromal tumor Gastrointestinal stromal tumor, somatic 606764
Hypereosinophilic syndrome, idiopathic, resistant to imatinib 607685
GENE ONTOLOGY
Ontology GO Term
Biological Process cerebellum vasculature development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016243 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027290 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdgfra-002 (1) 6274
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    ab1-PDGFRA (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfra No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdgfraContained in: [BAC] CH211-176L11 (1) (order this), DKEY-97C6 (1) (order this)
    pdgfraEncodes: [EST] fc27f02, fv91b12
    [cDNA] cssl:d115 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131459 (1) 3788bp
    Genomic GenBank:BX276097 (1) 216655bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QNY7 (1) 1456aa
    Sequence Clusters UniGene:75077 (1)
    Sequence Information (all 27)
    OTHER pdgfra GENE PAGES
  • Gene:386856 (1)
  • VEGA:OTTDARG00000033821 (1)
  • Ensembl(GRCz10):ENSDARG00000070494 (1)
  • ORTHOLOGY for pdgfra (Chr: 20)
    CITATIONS (45)