Gene

pdgfra

ID
ZDB-GENE-990415-208
Name
platelet-derived growth factor receptor, alpha polypeptide
Symbol
pdgfra Nomenclature History
Previous Names
  • pdgfr-a (1)
  • etID309717.20 (1)
  • wu:fc27f02
  • wu:fv91b12
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable platelet-derived growth factor alpha-receptor activity and platelet-derived growth factor binding activity. Acts upstream of or within several processes, including circulatory system development; embryonic neurocranium morphogenesis; and neural crest cell migration. Predicted to be located in Golgi apparatus and cilium. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; choroidal fissure; head; mesoderm; and neural crest. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pdgfra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gastrointestinal stromal tumor/GIST-plus syndrome, somatic or familial 175510
Hypereosinophilic syndrome, idiopathic, resistant to imatinib 607685
Associated With pdgfra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR027290 Platelet-derived growth factor receptor alpha
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Platelet-derived growth factor receptor alpha Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:Q9DE49 1059
UniProtKB:Q90269 457
UniProtKB:F1QNY7 1456
UniProtKB:B0CM00 913
UniProtKB:A4JYD9 1059
UniProtKB:Q5RID4 1101
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab1-PDGFRA polyclonal IgG Rabbit
  • WB
Millipore
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations