ZFIN ID: ZDB-GENE-990415-208
Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol: pdgfra    Nomenclature History

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Previous Names: pdgfr-a (1), etID309717.20 (1), wu:fc27f02, wu:fv91b12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have platelet-derived growth factor alpha-receptor activity and platelet-derived growth factor binding activity. Involved in several processes, including circulatory system development; embryonic neurocranium morphogenesis; and neural crest cell migration. Predicted to localize to several cellular components, including Golgi apparatus; cilium; and integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; choroidal fissure; head; mesoderm; and neural crest. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha).
Genome Resources: Alliance (1),  Gene:386856 (1),  Ensembl(GRCz11):ENSDARG00000070494 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1059 Point Mutation Unknown Missense ENU
la021462Tg Transgenic Insertion Unknown Unknown DNA
sa271 Point Mutation Unknown Premature Stop ENU
sa29348 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43427 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43428 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk16 Point Mutation Intron 15 Splice Site, Exon Loss of Exon 14, Frameshift, Premature Stop ENU
    smh1300Gt Transgenic Insertion Intron 16 Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pdgfra N/A 2
    MO2-pdgfra N/A 2
    MO3-pdgfra N/A 1
    DISEASE ASSOCIATED WITH pdgfra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Gastrointestinal stromal tumor/GIST-plus syndrome, somatic or familial 175510
    Hypereosinophilic syndrome, idiopathic, resistant to imatinib 607685
    DISEASE ASSOCIATED WITH pdgfra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum vasculature development (more)
    Cellular Component cilium (more)
    Molecular Function ATP binding (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pdgfra-201 (1)    Ensembl 6274
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    ab1-PDGFRA polyclonal IgG Rabbit WB Millipore
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfra No data available
    MARKER RELATIONSHIPS
    pdgfra Contained in: [BAC] CH211-176L11 (1), DKEY-97C6 (1) (order this)
    pdgfra Encodes: [EST] fc27f02, fv91b12
    [cDNA] cssl:d115 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131459 (1) 3788 nt
    Genomic GenBank:BX276097 (1) 216655 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QNY7 (1) 1456 aa
    Sequence Information (all 27)
    ORTHOLOGY for pdgfra ( Chr: 20 )
    CITATIONS (62)