ZFIN ID: ZDB-GENE-990415-208
Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol: pdgfra
Previous Names: pdgfr-a (1), etID309717.20 (1), wu:fc27f02, wu:fv91b12
Location: Chr: 20 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 16 figures from 8 publications
Directly Submitted Expression Data: 6 figures (32 images) from Thisse et al., 2008 [cssl:d115]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  choroidal fissure, cranial blood vessel, cranial neural crest, cranial neural crest cell (all 26) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
b1059 Point Mutation ENU
la021462Tg Transgenic Insertion DNA
Targeting reagents: MO1-pdgfra (1), MO2-pdgfra (1)
PHENOTYPE
Data: 4 figures from 2 publications
Observed in: cranial vasculature, cranium, ethmoid cartilage, lip (all 7) expand
DISEASE ASSOCIATED WITH pdgfra HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
gastrointestinal stromal tumor Gastrointestinal stromal tumor, somatic 606764
Hypereosinophilic syndrome, idiopathic, resistant to imatinib 607685
GENE ONTOLOGY
Ontology GO Term
Biological Process cerebellum vasculature development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016243 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027290 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdgfra-002 (1) 6274
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    ab1-PDGFRA (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfra No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdgfraContained in: [BAC] CH211-176L11 (1) (order this), DKEY-97C6 (1) (order this)
    pdgfraEncodes: [EST] fc27f02, fv91b12
    [cDNA] cssl:d115 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131459 (1) 3788bp
    Genomic GenBank:BX276097 (1) 216655bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QNY7 (1) 1456aa
    Sequence Clusters UniGene:75077 (1)
    Sequence Information (all 27)
    OTHER pdgfra GENE PAGES
  • Gene:386856 (1)
  • VEGA:OTTDARG00000033821 (1)
  • Ensembl(GRCz10):ENSDARG00000070494 (1)
  • ORTHOLOGY for pdgfra (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human PDGFRA 4
  • Gene:5156
  • OMIM:173490
  • HGNC:8803
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (2)
    Mouse Pdgfra 5
  • MGI:97530
  • Gene:18595
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (40)