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ZIRC
ZFIN ID: ZDB-GENE-980526-558
Gene Name: WT1 transcription factor a
Gene Symbol: wt1a    Nomenclature History

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Previous Names: wt1, zwt1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in animal organ development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Is expressed in several structures, including cardiovascular system; gonad primordium; mesoderm; pleuroperitoneal region; and podocyte. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources: Alliance (1),  Gene:30245 (1),  Ensembl(GRCz11):ENSDARG00000031420 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17769 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wt1a N/A 2
    MO2-wt1a N/A 5
    MO3-wt1a N/A 3
    MO4-wt1a N/A 2
    MO5-wt1a N/A 1
    MO6-wt1a,wt1b N/A 1
    TALEN1-wt1a
    1
    DISEASE ASSOCIATED WITH wt1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
    Frasier syndrome Alliance Frasier syndrome 136680
    malignant mesothelioma Alliance Mesothelioma, somatic 156240
    nephroblastoma Alliance Wilms tumor, type 1 194070
    nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
    Meacham syndrome 608978
    DISEASE ASSOCIATED WITH wt1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adrenal gland development (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wt1a-201 (1)    Ensembl 1874
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-wt1 polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wt1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.8wt1a:Cre-ERT2) wt1a CreERT2 Danio rerio 1 3
    Tg(-35.1wt1a:EGFP) wt1a EGFP Danio rerio 3 10
    Tg1(-6.8wt1a:EGFP) wt1a EGFP Danio rerio 3 7
    Tg2(-6.8wt1a:EGFP) wt1a EGFP Danio rerio 3 2
    MARKER RELATIONSHIPS
    wt1a Contained in: [BAC] CH73-152I22 (1) (order this), DKEY-114A13 (1) (order this)
    wt1a Encodes: [EST] eu357 (1)
    [cDNA] MGC:193986 (1) (order this), MGC:193994 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131046 (1) 1807 bp
    Genomic GenBank:CR762411 (1) 35418 bp
    Select Tool
    Polypeptide UniProtKB:Q9PUT7 (1) 419 aa
    Sequence Clusters UniGene:132864 (1)
    Sequence Information (all 24)
    ORTHOLOGY for wt1a ( Chr: 25 )
    CITATIONS (128)