Gene

wt1a

ID
ZDB-GENE-980526-558
Name
WT1 transcription factor a
Symbol
wt1a Nomenclature History
Previous Names
  • wt1
  • zwt1
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in animal organ development. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; gonad primordium; mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources
Note
None
Expression
All Expression Data
93 figures from 57 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wt1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
Frasier syndrome Alliance Frasier syndrome 136680
malignant mesothelioma Alliance Mesothelioma, somatic 156240
nephroblastoma Alliance Wilms tumor, type 1 194070
nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
Meacham syndrome 608978
Associated With wt1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000976 Wilm's tumour protein, N-terminal
Domain IPR013087 Zinc finger C2H2-type
Family IPR017987 Wilm's tumour protein
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Wilm's tumour protein Wilm's tumour protein, N-terminal Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q9PUT7 419
UniProtKB:Q98SJ4 250
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-wt1 polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations