Gene
wnt1
- ID
- ZDB-GENE-980526-526
- Name
- wingless-type MMTV integration site family, member 1
- Symbol
- wnt1 Nomenclature History
- Previous Names
-
- int-1
- etID22400.23 (1)
- sb:eu647
- zgc:194464
- zgc:194478
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and frizzled binding activity. Involved in brain development. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 111 figures from 79 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu647 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 15 | Alliance | Osteogenesis imperfecta, type XV | 615220 |
| {Osteoporosis, early-onset, susceptibility to, autosomal dominant} | 615221 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-1 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:P24257
|
370 | ||||
|
UniProtKB:A0A0B5JWC2
|
370 | ||||
|
UniProtKB:B3DI55
|
370 |
Interactions and Pathways
No data available
Plasmids