ZFIN ID: ZDB-GENE-980526-526
Gene Name: wingless-type MMTV integration site family, member 1
Gene Symbol: wnt1    Nomenclature History

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Previous Names: int-1, etID22400.23 (1), sb:eu647, zgc:194464, zgc:194478

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in brain development. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Orthologous to human WNT1 (Wnt family member 1).
Genome Resources: Alliance (1),  Gene:30128 (1),  Ensembl(GRCz11):ENSDARG00000055554 (1)
GENE EXPRESSION
All Expression Data: 108 figures from 76 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu647]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24353 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wnt1 N/A 4
    MO2-wnt1 N/A 3
    MO3-wnt1 N/A 1
    DISEASE ASSOCIATED WITH wnt1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    osteogenesis imperfecta type 15 Alliance Osteogenesis imperfecta, type XV 615220
    {Osteoporosis, early-onset, susceptibility to, autosomal dominant} 615221
    DISEASE ASSOCIATED WITH wnt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process midbrain-hindbrain boundary development (more)
    Cellular Component extracellular region (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018161 Wnt protein, conserved site
    Family IPR005817 Wnt
    Family IPR009139 Wnt-1 protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wnt1-201 (1)    Ensembl 1360
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.6wnt1:GAL4-VP16-6.7wnt1,14xUAS-E1B:EGFP) E1Bwnt1 EGFPGAL4VP16 Danio rerio 1 5
    Tg(wnt1:EGFP) wnt1 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    wnt1 Contained in: [BAC] DKEY-166N8 (1) (order this)
    wnt1 Encodes: [EST] eu647 (1)
    [cDNA] MGC:194464 (1), MGC:194478 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001201398 (1)
    Genomic GenBank:CR352210 (1) 180924 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JWC2 (1) 370 aa
    Sequence Information (all 25)
    ORTHOLOGY for wnt1 ( Chr: 23 )
    CITATIONS (175)