ZFIN ID: ZDB-GENE-980526-52
Gene Name: paired box 3a
Gene Symbol: pax3a    Nomenclature History

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Previous Names: pax3 (1), etID309899.2 (1), zgc:92547

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in enteric nervous system development; neural crest cell migration; and xanthophore differentiation. Localizes to the nucleus. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 3; Waardenburg's syndrome; alveolar rhabdomyosarcoma; and craniofacial-deafness-hand syndrome. Is expressed in several structures, including muscle; nervous system; neural crest; neural tube; and paraxial mesoderm. Orthologous to human PAX3 (paired box 3).
Genome Resources: Alliance (1),  Gene:30532 (1),  Ensembl(GRCz11):ENSDARG00000010192 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011736Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014990Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014991Tg Transgenic Insertion Unknown Unknown DNA
    sa33020 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39931 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pax3a N/A 2
    MO2-pax3a N/A 3
    MO3-pax3a N/A 3
    MO4-pax3a N/A 3
    DISEASE ASSOCIATED WITH pax3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma 2, alveolar 268220
    craniofacial-deafness-hand syndrome Alliance Craniofacial-deafness-hand syndrome 122880
    Waardenburg syndrome type 1 Alliance Waardenburg syndrome, type 1 193500
    Waardenburg syndrome type 3 Alliance Waardenburg syndrome, type 3 148820
    DISEASE ASSOCIATED WITH pax3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Domain IPR001523 Paired domain
    Domain IPR022106 Paired box protein 7, C-terminal
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pax3a-202 (1)    Ensembl 2713
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pax3a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(pax3a:EGFP) pax3a EGFP Danio rerio 1 4
    Tg(pax3a:KALTA4,cryaa:EGFP) cryaapax3a EGFPKALTA4 Danio rerio 1 3
    TgBAC(pax3a:EGFP) pax3a EGFP Danio rerio 1 10
    MARKER RELATIONSHIPS
    pax3a Contained in: [BAC] DKEY-20F20 (1) (order this)
    pax3a Encodes: [cDNA] MGC:92547 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131277 (1) 2734 nt
    Genomic GenBank:BX085193 (1) 246911 nt Blast at MegaBLAST
    Polypeptide UniProtKB:O57416 (1) 509 aa
    Sequence Information (all 16)
    ORTHOLOGY for pax3a ( Chr: 2 )
    CITATIONS (107)