ZFIN ID: ZDB-GENE-980526-416
Gene Name: wingless-type MMTV integration site family member 2
Gene Symbol: wnt2    Nomenclature History

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Previous Names: etID309852.18 (1), ZfWnt2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have cytokine activity and frizzled binding activity. Involved in hepatocyte proliferation and swim bladder development. Predicted to localize to extracellular space. Is expressed in several structures, including nervous system; optic cup; optic vesicle; otic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2).
Genome Resources: Alliance (1),  Gene:30127 (1),  Ensembl(GRCz11):ENSDARG00000041117 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2847 Point Mutation Unknown Unknown ENU
hu2848 Point Mutation Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-wnt2 N/A 1
MO2-wnt2 N/A 1
MO3-wnt2 N/A 1
DISEASE ASSOCIATED WITH wnt2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH wnt2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process liver development (more)
Cellular Component extracellular region (more)
Molecular Function signaling receptor binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA wnt2-201 (1)    Ensembl 1509
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM wnt2
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:mCherry,wnt2) hsp70l mCherrywnt2 Danio rerio 1 2
MARKER RELATIONSHIPS
wnt2 Contained in: [BAC] CH211-238N5 (1), DKEY-270I2 (1) (order this)
wnt2 Contains: [SNP] rs3728908 (1), rs3728909 (1)
wnt2 Encodes: [cDNA] MGC:65730 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130950 (1) 1509 nt
Genomic GenBank:BX470130 (1) 191401 nt
Select Tool
Polypeptide UniProtKB:Q92048 (1) 350 aa
Sequence Information (all 14)
ORTHOLOGY for wnt2 ( Chr: 18 )
CITATIONS (52)